Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0051 | 0.9482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3955 | 0.3955 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.003 | 0.3955 | 0.3955 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.6749 | 0.6749 |
Mycobacterium ulcerans | B12-dependent methionine synthase | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.6749 | 0.6749 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1348 | 0.1348 |
Entamoeba histolytica | aminopeptidase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4142 | 0.4142 |
Echinococcus granulosus | aminopeptidase N | 0.0051 | 0.9482 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.002 | 0.1446 | 0.1446 |
Mycobacterium ulcerans | zinc metalloprotease | 0.004 | 0.6749 | 0.6749 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0041 | 0.6917 | 0.6917 |
Onchocerca volvulus | 0.002 | 0.1348 | 0.1348 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4142 | 0.4142 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.002 | 0.1446 | 0.1446 |
Onchocerca volvulus | 0.0051 | 0.9482 | 0.9482 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.002 | 0.1446 | 0.1446 |
Onchocerca volvulus | 0.0053 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3955 | 0.3955 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.002 | 0.1446 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4142 | 0.4142 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.002 | 0.1446 | 0.1446 |
Plasmodium vivax | homocysteine S-methyltransferase, putative | 0.0053 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.003 | 0.3955 | 0.3955 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.004 | 0.6749 | 0.6749 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.004 | 0.6749 | 0.7118 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.6749 | 0.6749 |
Trypanosoma brucei | unspecified product | 0.0053 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 1 | 1 |
Leishmania major | homocysteine S-methyltransferase, putative | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.8091 | 0.8091 |
Trypanosoma cruzi | cytidine triphosphate synthase, putative | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3955 | 0.3955 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4142 | 0.4142 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4142 | 0.4142 |
Mycobacterium leprae | Probable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS) | 0.0053 | 1 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.004 | 0.6749 | 0.6749 |
Leishmania major | methionine synthase, putative | 0.0053 | 1 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.004 | 0.6749 | 0.7118 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4142 | 0.4142 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5526 | 0.5526 |
Trypanosoma cruzi | homocysteine S-methyltransferase, putative | 0.0053 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | homocysteine S-methyltransferase, putative | 0.0053 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0051 | 0.9482 | 0.9482 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3955 | 0.3955 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.004 | 0.6749 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.004 | 0.6749 | 0.6749 |
Plasmodium falciparum | homocysteine S-methyltransferase, putative | 0.0053 | 1 | 0.5 |
Toxoplasma gondii | homocysteine s-methyltransferase domain-containing protein | 0.0053 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -46 % | In vivo for cholesterol absorption inhibitory activity using 7-day cholesterol-fed hamster model (expressed as percent change in cholesteryl esters at 50 mg/kg/day) | ChEMBL. | 8809157 |
Change (functional) | = -21 % | In vivo cholesterol absorption inhibitory activity using 7-day cholesterol-fed hamster model (expressed as percent change in serum cholesterol at 50 mg/kg/day) | ChEMBL. | 8809157 |
Inhibition (binding) | = -6 % | In vitro for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomes at 50 microM | ChEMBL. | 8809157 |
Inhibition (binding) | = -6 % | In vitro for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomes at 50 microM | ChEMBL. | 8809157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.