Detailed view for MUL_3812

Basic information

TDR Targets ID: 952471
Mycobacterium ulcerans, hypothetical protein
Source Database / ID:  KEGG  

pI: 4.6022 | Length (AA): 441 | MW (Da): 46128 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01546   Peptidase family M20/M25/M40
PF07687   Peptidase dimerisation domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 441 2zog (A) 4 471 29.00 0 1 1.2977 -0.08
4 441 3pfe (A) 7 468 26.00 0 1 1.2472 -0.03
13 153 1q7l (A) 11 151 30.00 0.42 0.65 0.628128 -0.31
42 181 4q7a (A) 9 155 36.00 0.0026 0.78 0.42386 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127342)

Species Accession Gene Product
Brugia malayi Bm1_37280   hypothetical protein
Candida albicans CaO19.11397   similar to S. cerevisiae YFR044C
Candida albicans CaO19.3915   similar to S. cerevisiae YFR044C
Caenorhabditis elegans CELE_Y71H2AM.11   Protein Y71H2AM.11
Caenorhabditis elegans CELE_R11H6.1   Protein PES-9
Dictyostelium discoideum DDB_G0279291   hypothetical protein
Drosophila melanogaster Dmel_CG17337   CG17337 gene product from transcript CG17337-RA
Echinococcus granulosus EgrG_000992300   cytosolic non specific dipeptidase
Echinococcus multilocularis EmuJ_000992300   cytosolic non specific dipeptidase
Homo sapiens ENSG00000133313   CNDP dipeptidase 2 (metallopeptidase M20 family)
Homo sapiens ENSG00000150656   carnosine dipeptidase 1 (metallopeptidase M20 family)
Leishmania braziliensis LbrM.33.1880   peptidase M20/M25/M40, putative
Leishmania braziliensis LbrM.31.2100   peptidase m20/m25/m40 family-like protein
Leishmania braziliensis LbrM.31.2120   peptidase m20/m25/m40 family-like protein
Leishmania braziliensis LbrM.33.2100   peptidase M20/M25/M40, putative
Leishmania braziliensis LbrM.31.2280   succinyl-diaminopimelate desuccinylase-like protein
Leishmania donovani LdBPK_331710.1   cytosolic nonspecific dipeptidase, putative
Leishmania donovani LdBPK_312060.1   succinyl-diaminopimelate desuccinylase-like protein
Leishmania infantum LinJ.33.1710   peptidase M20/M25/M40, putative
Leishmania infantum LinJ.31.2060   succinyl-diaminopimelate desuccinylase-like protein
Leishmania major LmjF.33.1610   peptidase M20/M25/M40, putative
Leishmania major LmjF.31.1890   peptidase m20/m25/m40 family-like protein
Leishmania major LmjF.31.2020   succinyl-diaminopimelate desuccinylase-like protein
Leishmania mexicana LmxM.30.2020   succinyl-diaminopimelate desuccinylase-like protein
Leishmania mexicana LmxM.30.1890   peptidase m20/m25/m40 family-like protein
Leishmania mexicana LmxM.32.1610   peptidase M20/M25/M40, putative
Loa Loa (eye worm) LOAG_10052   cytosolic non-specific dipeptidase
Mycobacterium leprae ML1193   conserved hypothetical protein
Mus musculus ENSMUSG00000024644   CNDP dipeptidase 2 (metallopeptidase M20 family)
Mus musculus ENSMUSG00000056162   carnosine dipeptidase 1 (metallopeptidase M20 family)
Mycobacterium tuberculosis Rv2522c   Conserved hypothetical protein
Mycobacterium ulcerans MUL_3812   hypothetical protein
Saccharomyces cerevisiae YFR044C   metallodipeptidase
Schmidtea mediterranea mk4.025490.00  
Schmidtea mediterranea mk4.033352.00  
Schmidtea mediterranea mk4.003046.02  
Schmidtea mediterranea mk4.010005.00  
Trypanosoma brucei gambiense Tbg972.10.14780   cytosolic nonspecific dipeptidase, putative,peptidase (M20/M25/M40 family), putative
Trypanosoma brucei gambiense Tbg972.6.80   peptidase M20/M25/M40, putative
Trypanosoma brucei Tb927.6.400   peptidase M20/M25/M40, putative
Trypanosoma brucei Tb927.10.12260   cytosolic nonspecific dipeptidase, putative
Trypanosoma congolense TcIL3000_10_10490   cytosolic nonspecific dipeptidase, putative
Trypanosoma cruzi TcCLB.510257.80   cytosolic nonspecific dipeptidase, putative
Trypanosoma cruzi TcCLB.509213.120   cytosolic nonspecific dipeptidase, putative
Toxoplasma gondii TGME49_213060   WD domain, G-beta repeat-containing protein
Trichomonas vaginalis TVAG_370490   Clan MH, family M20, peptidase T-like metallopeptidase
Trichomonas vaginalis TVAG_224980   Clan MH, family M20, peptidase T-like metallopeptidase

Essentiality

MUL_3812 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.400 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.400 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.400 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.400 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.12260 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.12260 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.12260 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.12260 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_213060 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.001 1 0.5
0.0003 1 0.5
0.0003 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier MUL_3812 (Mycobacterium ulcerans), hypothetical protein
Title for this comment
Comment