Detailed view for EmuJ_000498400

Basic information

TDR Targets ID: 957014
Echinococcus multilocularis, lysocardiolipin acyltransferase 1
Source Database / ID:  GeneDB

pI: 8.4553 | Length (AA): 391 | MW (Da): 44225 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01553   Acyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016746   transferase activity, transferring acyl groups  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
96 230 4g1h (A) 86 206 34.00 0.1 0.06 0.244869 2.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128431)

Species Accession Gene Product
Arabidopsis thaliana AT3G18850   lysophosphatidyl acyltransferase 5
Arabidopsis thaliana AT1G75020   lysophosphatidyl acyltransferase 4
Brugia malayi Bm1_55355   Protein FAM34A
Brugia malayi Bm1_04260   Hypothetical 45.9 kDa protein in KCS1-GCV1 intergenic region
Candida albicans CaO19.7781   possible role in phospholipid biosynthesis
Candida albicans CaO19.137   possible role in phospholipid biosynthesis
Caenorhabditis elegans CELE_T05H4.1   Protein ACL-8
Caenorhabditis elegans CELE_F55A11.5   Protein BUS-18
Dictyostelium discoideum DDB_G0269848   hypothetical protein
Echinococcus granulosus EgrG_000498400   lysocardiolipin acyltransferase 1
Echinococcus multilocularis EmuJ_000498400   lysocardiolipin acyltransferase 1
Homo sapiens ENSG00000172954   lysocardiolipin acyltransferase 1
Leishmania braziliensis LbrM.17.0930   hypothetical protein, conserved
Leishmania donovani LdBPK_171010.1   acyltransferase, putative
Leishmania infantum LinJ.17.1010   hypothetical protein, conserved
Leishmania major LmjF.17.0910   hypothetical protein, conserved
Leishmania mexicana LmxM.17.0910   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05545   hypothetical protein
Loa Loa (eye worm) LOAG_04170   hypothetical protein
Loa Loa (eye worm) LOAG_10647   ACL-8 protein
Mus musculus ENSMUSG00000054469   lysocardiolipin acyltransferase 1
Oryza sativa 4327848   Os01g0782500
Oryza sativa 4339242   Os05g0502200
Onchocerca volvulus OVOC7311  
Saccharomyces cerevisiae YBR042C   Cst26p
Saccharomyces cerevisiae YDR018C   putative acyltransferase
Schistosoma japonicum Sjp_0309360   ko:K00655 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC2.3.1.51], putative
Schistosoma mansoni Smp_095580   1-acylglycerol-3-phosphate acyltransferase
Schmidtea mediterranea mk4.002084.15   Putative 1-acylglycerol-3-phosphate acyltransferase
Trypanosoma brucei gambiense Tbg972.5.3210   acetyltransferase, putative
Trypanosoma brucei Tb927.5.2280   acetyltransferase, putative
Trypanosoma congolense TcIL3000_5_2060   acetyltransferase, putative
Trypanosoma cruzi TcCLB.511315.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511755.50   hypothetical protein, conserved

Essentiality

EmuJ_000498400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.2280 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.2280 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.2280 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.5.2280 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0006 0.5 0.5
0.0006 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000498400 (Echinococcus multilocularis), lysocardiolipin acyltransferase 1
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