Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.8341 | 0.717 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0094 | 0.4135 | 0.4135 |
Brugia malayi | hypothetical protein | 0.0094 | 0.4135 | 0.4135 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0094 | 0.4135 | 0.4135 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0094 | 0.4135 | 0.4135 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0486 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.5615 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Echinococcus multilocularis | geminin | 0.0173 | 0.8341 | 0.717 |
Onchocerca volvulus | 0.011 | 0.4978 | 0.1438 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0486 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0486 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.5615 | 0.5615 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0486 | 0.5 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0094 | 0.4135 | 0.3836 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.011 | 0.4978 | 0.4978 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Echinococcus granulosus | nAChR subunit | 0.011 | 0.4978 | 0.1438 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.011 | 0.4978 | 0.1438 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0094 | 0.4135 | 0.4135 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0094 | 0.4135 | 0.3836 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.4978 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.011 | 0.4978 | 0.4978 |
Onchocerca volvulus | 0.011 | 0.4978 | 0.1438 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0486 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Brugia malayi | hypothetical protein | 0.0094 | 0.4135 | 0.4135 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Loa Loa (eye worm) | GABA receptor subunit | 0.011 | 0.4978 | 0.4722 |
Brugia malayi | hypothetical protein | 0.0094 | 0.4135 | 0.4135 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0094 | 0.4135 | 0.4135 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0486 | 0.5 |
Brugia malayi | hypothetical protein | 0.0094 | 0.4135 | 0.4135 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.011 | 0.4978 | 0.4978 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.011 | 0.4978 | 0.4978 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.8341 | 0.717 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0094 | 0.4135 | 0.3836 |
Brugia malayi | hypothetical protein | 0.0094 | 0.4135 | 0.4135 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0486 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.011 | 0.4978 | 0.1438 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4978 | 0.4722 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0486 | 0.0486 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.011 | 0.4978 | 0.1438 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0094 | 0.4135 | 0.4135 |
Echinococcus multilocularis | nAChR subunit | 0.011 | 0.4978 | 0.1438 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.5615 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4135 | 0.3836 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0486 | 0.5 |
Echinococcus granulosus | geminin | 0.0173 | 0.8341 | 0.717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.