Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase IV | 312 aa | 270 aa | 26.7 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.1928 | 0.3395 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.5679 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.4233 | 0.7455 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.2743 | 0.483 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0049 | 0.0207 | 0.0207 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.1928 | 0.3395 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0163 | 0.3998 | 0.3998 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0163 | 0.3998 | 0.3998 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0124 | 0.0219 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0124 | 0.0219 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.5679 | 0.5679 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.1928 | 0.3395 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.5679 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.5679 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1928 | 0.3395 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.1928 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0124 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1928 | 0.3395 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.2743 | 0.483 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0124 | 0.0219 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0049 | 0.0207 | 0.0207 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.1928 | 0.3395 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.5679 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.5679 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.1928 | 0.3395 |
Echinococcus granulosus | geminin | 0.0171 | 0.4233 | 0.7455 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.5679 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.1928 | 0.3395 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.5679 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.4233 | 0.7455 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0182 | 0.4607 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0163 | 0.3998 | 0.3998 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0124 | 0.0219 |
Echinococcus multilocularis | geminin | 0.0171 | 0.4233 | 0.7455 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1928 | 0.3395 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.5679 | 0.5679 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.1928 | 0.3395 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0124 | 0.0219 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0124 | 0.0219 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.1928 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.5679 | 0.5679 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0049 | 0.0207 | 0.0207 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0059 | 0.0558 | 0.0558 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0124 | 0.0219 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0049 | 0.0207 | 0.0207 |
Mycobacterium ulcerans | hypothetical protein | 0.0182 | 0.4607 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1928 | 0.3395 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.1928 | 0.3395 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.2743 | 0.483 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0124 | 0.0219 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.5679 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.1928 | 0.3395 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.5679 | 0.5679 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 63 nM | Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assay | ChEMBL. | 19854054 |
Ki (binding) | = 1520 nM | Inhibition of human carbonic anhydrase 1 by CO2 hydrase stopped flow assay | ChEMBL. | 19854054 |
Ki (binding) | = 3905 nM | Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assay | ChEMBL. | 19854054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.