Detailed information for compound 1183963

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.444 | Formula: C20H24N6O2
  • H donors: 4 H acceptors: 2 LogP: 0.48 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C(=N)N)CCCCC(=O)Nc1cccc(c1)C(=N)N
  • InChi: 1S/C20H24N6O2/c21-19(22)13-5-3-7-15(11-13)25-17(27)9-1-2-10-18(28)26-16-8-4-6-14(12-16)20(23)24/h3-8,11-12H,1-2,9-10H2,(H3,21,22)(H3,23,24)(H,25,27)(H,26,28)
  • InChiKey: LIUVPUBLZYZZAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0617 0.8981
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.032 0.1248
Schistosoma mansoni chromobox protein 0.0066 0.2899 0.4727
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0398 0.0951
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0351 0.0837
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0813 0.1956
Trichomonas vaginalis chromobox protein, putative 0.004 0.1526 0.3686
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0438 0.0608
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0292 0.0466
Echinococcus granulosus JmjC domain containing protein 4 0.0024 0.0686 0.0958
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0438 0.3507
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0601 0.2564
Schistosoma mansoni jumonji domain containing protein 0.0128 0.6125 1
Echinococcus granulosus jumonji domain containing protein 0.0038 0.1454 0.2041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0166 0.0388
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0617 0.8981
Mycobacterium ulcerans hypothetical protein 0.0023 0.0656 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0601 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0617 0.0869
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0398 0.03
Loa Loa (eye worm) jmjC domain-containing protein 0.0091 0.4198 0.6048
Brugia malayi chromobox protein homolog 3 0.0037 0.1379 0.1942
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0141 0.6855 0.9876
Echinococcus multilocularis cpg binding protein 0.0031 0.105 0.1472
Loa Loa (eye worm) hypothetical protein 0.0024 0.0686 0.0988
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0023 0.0656 1
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.4129 1
Brugia malayi hypothetical protein 0.0011 0.0006 0.0009
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0023 0.0656 0.1577
Brugia malayi PHD-finger family protein 0.0028 0.0887 0.125
Brugia malayi jmjC domain containing protein 0.0024 0.0686 0.0966
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0617 0.1482
Brugia malayi CHD4 protein 0.0012 0.0093 0.0131
Loa Loa (eye worm) heterochromatin protein 1 0.0066 0.2899 0.4176
Onchocerca volvulus 0.0079 0.3567 0.5135
Brugia malayi Heterochromatin protein 1 0.0066 0.2899 0.4083
Echinococcus granulosus lysine specific demethylase 5A 0.0091 0.4198 0.591
Trichomonas vaginalis chromobox protein, putative 0.0066 0.2899 0.7015
Leishmania major hypothetical protein, conserved 0.0024 0.0686 0.03
Trichomonas vaginalis chromobox protein, putative 0.004 0.1526 0.3686
Trypanosoma cruzi polo-like protein kinase, putative 0.0089 0.4129 0.3886
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0006 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.4129 0.6738
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0617 0.8835
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0438 0.1046
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.1454 0.2041
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.1379 0.3329
Giardia lamblia PHD finger protein 15 0.0028 0.0887 0.1311
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0351 0.0837
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0617 0.8835
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0023 0.0656 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0398 0.0553
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0093 0.0122
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0438 0.0041
Brugia malayi SET domain containing protein 0.0011 0.0039 0.0056
Onchocerca volvulus 0.0011 0.0039 0.0048
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.032 0.3557
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.1761 0.4257
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0608 0.0876
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0006 0.0002
Schistosoma mansoni phd/f-box containing protein 0.0024 0.0686 0.1111
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.2428 0.3498
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0601 0.675
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0438 0.4897
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0617 1
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.4129 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0351 0.0837
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0686 0.0988
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0963 0.1388
Loa Loa (eye worm) hypothetical protein 0.0143 0.6941 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0601 0.2564
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0037 0.1379 0.1979
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0089 0.4129 0.5812
Onchocerca volvulus 0.0022 0.0617 0.0881
Entamoeba histolytica hypothetical protein 0.0022 0.0601 0.1442
Echinococcus multilocularis L aminoadipate semialdehyde 0.0079 0.3567 0.502
Onchocerca volvulus Alhambra homolog 0.0028 0.0887 0.1271
Brugia malayi Cytochrome P450 family protein 0.0022 0.0608 0.0857
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0398 0.0641
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0398 0.3291
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0023 0.0656 0.0269
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0093 0.0134
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0601 0.675
Loa Loa (eye worm) hypothetical protein 0.0062 0.27 0.389
Brugia malayi CXXC zinc finger family protein 0.0029 0.0963 0.1357
Brugia malayi jmjC domain containing protein 0.0091 0.4198 0.5913
Toxoplasma gondii exonuclease III APE 0.0019 0.0438 0.186
Echinococcus granulosus peregrin 0.0028 0.0887 0.1242
Schistosoma mansoni cpg binding protein 0.0029 0.0963 0.1564
Brugia malayi jmjC domain containing protein 0.0024 0.0686 0.0966
Schistosoma mansoni phosphatidylserine receptor 0.0024 0.0686 0.1111
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.2326 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0887 0.3799
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0398 0.03
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0887 0.1278
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.4129 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0023 0.0656 0.0916
Echinococcus multilocularis jumonji domain containing 1A 0.0024 0.0686 0.0958
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0023 0.0656 1
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.4129 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0438 0.0106
Loa Loa (eye worm) helicase 0.0011 0.0006 0.0009
Schistosoma mansoni kinase 0.0045 0.1823 0.2969
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0438 0.4317
Loa Loa (eye worm) hypothetical protein 0.0017 0.032 0.046
Trichomonas vaginalis chromobox protein, putative 0.0066 0.2899 0.7015
Loa Loa (eye worm) hypothetical protein 0.0022 0.0617 0.0889
Schistosoma mansoni ap endonuclease 0.0019 0.0438 0.0705
Loa Loa (eye worm) hypothetical protein 0.0017 0.032 0.046
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0006 0.0009
Brugia malayi Protein cec-1. 0.0011 0.0006 0.0009
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.032 0.3557
Schistosoma mansoni hypothetical protein 0.0028 0.0887 0.144
Entamoeba histolytica serine/threonine protein kinase, putative 0.0089 0.4129 1
Echinococcus granulosus muscleblind protein 0.0141 0.6855 0.9656
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0351 0.0837
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0398 0.2335
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0438 0.4897
Echinococcus multilocularis peregrin 0.0028 0.0887 0.1242
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.4129 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0617 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0398 0.0553
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0617 0.0869
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0398 0.0561
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0191 0.0449
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0438 0.063
Echinococcus multilocularis JmjC domain containing protein 4 0.0024 0.0686 0.0958
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0601 0.8357
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0351 0.0837
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0093 0.0122
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0686 0.03
Mycobacterium ulcerans hypothetical protein 0.0023 0.0656 1
Trypanosoma brucei polo-like protein kinase 0.0089 0.4129 0.4069
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.0398 0.3291
Echinococcus granulosus lysine specific demethylase 6a 0.0024 0.0686 0.0958
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0617 0.0228
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0079 0.3567 0.582
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0146 0.7099 1
Schistosoma mansoni cpg binding protein 0.0031 0.105 0.1706
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0011 0.0039 0.0054
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0089 0.4129 0.3886
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0191 0.0449
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Mycobacterium tuberculosis Conserved protein 0.0023 0.0656 1
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0006 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0351 0.0837
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0617 0.8835
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0887 1
Mycobacterium ulcerans hypothetical protein 0.0022 0.0617 0.8835
Echinococcus granulosus chromobox protein 1 0.0066 0.2899 0.4078
Echinococcus multilocularis citrate lyase subunit beta protein 0.0023 0.0656 0.0916
Trypanosoma cruzi polo-like protein kinase, putative 0.0089 0.4129 0.3886
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0089 0.4129 0.5812
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0813 0.1956
Echinococcus granulosus chromobox protein 1 0.0066 0.2899 0.4078
Onchocerca volvulus 0.0143 0.6941 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0617 0.0228
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0024 0.0686 0.0591
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0438 0.0608
Brugia malayi jmjC domain containing protein 0.0146 0.7099 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0601 1
Echinococcus granulosus dna polymerase kappa 0.0018 0.0398 0.0553
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0398 0.03
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0438 0.1046
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0601 0.8357
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Loa Loa (eye worm) hypothetical protein 0.0022 0.0617 0.0889
Schistosoma mansoni cpg binding protein 0.0031 0.105 0.1706
Brugia malayi Bromodomain containing protein 0.0028 0.0887 0.125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0438 0.0041
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0887 0.1242
Brugia malayi serine/threonine-protein kinase plk-2 0.0089 0.4129 0.5816
Echinococcus granulosus phd:f box containing protein 0.0024 0.0686 0.0958
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0773 0.1081
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0093 0.0142
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0887 0.1278
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0398 0.0641
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0024 0.0686 0.1111
Brugia malayi Muscleblind-like protein 0.0141 0.6855 0.9656
Brugia malayi jmjC domain containing protein 0.0024 0.0686 0.0966
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0438 0.034
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0146 0.7099 1
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.4129 1
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0398 0.0553
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0006 0.0002
Echinococcus granulosus L aminoadipate semialdehyde 0.0079 0.3567 0.502
Loa Loa (eye worm) hypothetical protein 0.0141 0.6855 0.9876
Schistosoma mansoni jumonji/arid domain-containing protein 0.0091 0.4198 0.6851
Brugia malayi jmjC domain containing protein 0.0024 0.0686 0.0966
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0601 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0617 0.8835
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0398 0.0574
Echinococcus multilocularis dna polymerase eta 0.0018 0.0398 0.0553
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0089 0.4129 0.5949
Loa Loa (eye worm) hypothetical protein 0.0017 0.032 0.046
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0398 0.2335
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0351 0.0837
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0773 0.1081
Echinococcus multilocularis chromobox protein 1 0.0066 0.2899 0.4078
Schistosoma mansoni jumonji/arid domain-containing protein 0.0091 0.4198 0.6851
Schistosoma mansoni chromobox protein 0.0066 0.2899 0.4727
Plasmodium falciparum JmjC domain-containing protein, putative 0.0024 0.0686 0.7713
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0398 0.03
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0617 0.8835
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0006 0.0002
Plasmodium vivax JmjC domain containing protein 0.0024 0.0686 0.7713
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0438 0.0616
Echinococcus multilocularis lysine specific demethylase 5A 0.0089 0.4111 0.5787
Brugia malayi hypothetical protein 0.0143 0.6941 0.9777
Loa Loa (eye worm) hypothetical protein 0.0017 0.032 0.046
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.1761 0.4257
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0617 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Onchocerca volvulus Serine\/threonine kinase homolog 0.0089 0.4129 0.5945
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0006 0.0002
Echinococcus multilocularis lysine specific demethylase 6a 0.0024 0.0686 0.0958
Schistosoma mansoni ap endonuclease 0.0019 0.0438 0.0705
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0601 0.0505
Schistosoma mansoni protein phosphatase 2C 0.0024 0.0686 0.1111
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0601 0.0211
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0079 0.3567 0.5025
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.1379 0.3329
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.4129 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0686 0.0988
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.0686 0.0988
Schistosoma mansoni DNA polymerase eta 0.0018 0.0398 0.0641
Loa Loa (eye worm) hypothetical protein 0.0037 0.1379 0.1986
Loa Loa (eye worm) hypothetical protein 0.0029 0.096 0.1383
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0438 0.1046
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.2671 0.4355
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0887 0.3799
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.1526 0.2192
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0024 0.0686 0.293
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Loa Loa (eye worm) hypothetical protein 0.0079 0.3567 0.5139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0686 0.0988
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0617 0.1482
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0023 0.0656 0.0269
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0617 0.8835
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0024 0.0686 0.293
Echinococcus granulosus cpg binding protein 0.0031 0.105 0.1472
Loa Loa (eye worm) hypothetical protein 0.0022 0.0617 0.0889
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0378 0.0533
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0398 0.0951
Echinococcus multilocularis muscleblind protein 1 0.0141 0.6855 0.9656
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.032 0.046
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0601 0.8562
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0398 0.03
Onchocerca volvulus 0.0029 0.096 0.1375
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0023 0.0656 0.0269
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0024 0.0686 0.03
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0006 0.0009
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0023 0.0656 1
Onchocerca volvulus 0.0029 0.0963 0.138
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0617 0.0228
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0617 0.8835
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0398 0.0951
Schistosoma mansoni jumonji domain containing protein 0.0024 0.0686 0.1111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0351 0.0837
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0617 0.1482
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0398 0.0561
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0438 0.0041
Echinococcus multilocularis chromobox protein 1 0.0066 0.2899 0.4078
Trypanosoma brucei unspecified product 0.0018 0.0398 0.03
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0887 0.1242
Echinococcus granulosus dna polymerase eta 0.0018 0.0398 0.0553
Echinococcus granulosus jumonji domain containing 1A 0.0024 0.0686 0.0958
Echinococcus multilocularis phd:f box containing protein 0.0024 0.0686 0.0958
Plasmodium falciparum phd finger protein, putative 0.0028 0.0887 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0887 0.144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0398 0.0574
Echinococcus multilocularis muscleblind protein 0.0141 0.6855 0.9656
Giardia lamblia Kinase, PLK 0.0089 0.4129 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.021 uM Antitrypanosomal activity against Multidrug-resistant Trypanosoma brucei rhodesiense KETRI 243 ChEMBL. 19736009
IC50 (functional) = 0.041 uM Antitrypanosomal activity against pentamidine-sensitive Trypanosoma brucei brucei LAB 110 EATRO ChEMBL. 19736009

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 19736009

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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