Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase VA, mitochondrial | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | carbonic anhydrase-like protein | carbonic anhydrase VA, mitochondrial | 305 aa | 255 aa | 25.9 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase IV | 312 aa | 270 aa | 26.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.6786 | 0.4755 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.6786 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.2925 | 0.3706 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0162 | 0.3871 | 0.3871 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.2964 | 0.377 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.2925 | 0.3706 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.2925 | 0.3706 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.2925 | 0.3706 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0162 | 0.3871 | 0.3871 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0.2925 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.6786 | 0.6786 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.2925 | 0.3706 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.6786 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.2925 | 0.3706 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.6786 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.2964 | 0.377 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.6786 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.6786 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.6786 | 0.6786 |
Schistosoma mansoni | carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.2925 | 0.3706 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0.2925 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.2925 | 0.3706 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.2925 | 0.3706 |
Mycobacterium ulcerans | hypothetical protein | 0.018 | 0.4493 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.6786 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0059 | 0.0358 | 0.0358 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.018 | 0.4493 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.2964 | 0.377 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.2925 | 0.3706 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.6786 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.6786 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.6786 | 0.6786 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.2925 | 0.3706 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.2925 | 0.3706 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.2925 | 0.3706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.13 uM | Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 18990571 |
Ki (binding) | = 1.89 uM | Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 18990571 |
Ki (binding) | = 7.58 uM | Inhibition of truncated human cloned membrane-associated carbonic anhydrase 4 preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 18990571 |
Ki (binding) | = 9.3 uM | Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5A pre-incubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 18990571 |
Ki (binding) | = 23.1 uM | Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5B preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 18990571 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.