Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0345 | 0.4048 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0088 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0088 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.3165 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0088 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0088 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0088 | 0.0205 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0088 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0088 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0088 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0088 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0088 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.1471 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.4048 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0088 | 0.0205 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0088 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0365 | 0.4311 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0088 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0088 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0088 | 0.5 |
Brugia malayi | hypothetical protein | 0.0149 | 0.1471 | 0.3411 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0088 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0365 | 0.4311 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0088 | 0.0218 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0088 | 0.5 |
Echinococcus multilocularis | geminin | 0.0345 | 0.4048 | 0.4048 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0088 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0088 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0088 | 0.0205 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0088 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1471 | 0.3274 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0088 | 0.0205 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0088 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0088 | 0.0218 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0088 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0088 | 0.0088 |
Brugia malayi | MH2 domain containing protein | 0.0365 | 0.4311 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.4048 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.