Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0529 | 0.0529 |
Brugia malayi | nuclear receptor RXR | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0023 | 0.0347 | 0.0347 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | ecdysteroid receptor | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0.097 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0025 | 0.0529 | 0.0593 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0044 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0044 | 0.3239 | 0.3633 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.8138 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | nuclear receptor NHR-88 | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0044 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Giardia lamblia | Rrm3p helicase | 0.0028 | 0.097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.2311 | 0.2592 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0044 | 0.3239 | 0.3239 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0044 | 0.3239 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0025 | 0.0529 | 0.0593 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0036 | 0.2106 | 0.2362 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | FTZ F1 alpha | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0085 | 0.8915 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | thyroid hormone receptor | 0.0044 | 0.3239 | 0.3239 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0023 | 0.0347 | 0.0389 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0347 | 0.0347 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.8138 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.097 | 0.097 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0085 | 0.8915 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0044 | 0.3239 | 0.3239 |
Schistosoma mansoni | nuclear hormone receptor | 0.0044 | 0.3239 | 0.3239 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0028 | 0.097 | 0.1088 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | thyroid hormone receptor | 0.0044 | 0.3239 | 0.3239 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0044 | 0.3239 | 0.3239 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0036 | 0.2106 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | nuclear hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.7356 | 0.8251 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0347 | 0.0389 |
Trypanosoma brucei | cytochrome P450, putative | 0.0036 | 0.2106 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0036 | 0.2106 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0036 | 0.2106 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0044 | 0.3239 | 0.3239 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.2311 | 0.2592 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0036 | 0.2106 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0044 | 0.3239 | 0.3239 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0028 | 0.097 | 0.1088 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | steroid hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0044 | 0.3239 | 0.3239 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0044 | 0.3239 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0025 | 0.0529 | 0.0593 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0044 | 0.3239 | 1 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Schistosoma mansoni | coup transcription factor | 0.0044 | 0.3239 | 0.3239 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0085 | 0.8915 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0023 | 0.0347 | 0.0389 |
Onchocerca volvulus | 0.0044 | 0.3239 | 1 | |
Echinococcus multilocularis | voltage gated potassium channel | 0.0025 | 0.0529 | 0.0593 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0085 | 0.8915 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0044 | 0.3239 | 0.3239 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0.097 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | voltage gated potassium channel | 0.0025 | 0.0529 | 0.0593 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0529 | 0.0593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.