Detailed information for compound 1510006

Basic information

Technical information
  • TDR Targets ID: 1510006
  • Name: N-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3 -nitrobenzenesulfonamide
  • MW: 404.44 | Formula: C18H20N4O5S
  • H donors: 1 H acceptors: 5 LogP: 1.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=O)c1ccc(cc1)NS(=O)(=O)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C18H20N4O5S/c1-20-9-11-21(12-10-20)18(23)14-5-7-15(8-6-14)19-28(26,27)17-4-2-3-16(13-17)22(24)25/h2-8,13,19H,9-12H2,1H3
  • InChiKey: QSHNLSVYRDZOCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-nitro-benzenesulfonamide
  • N-[4-[(4-methyl-1-piperazinyl)-oxomethyl]phenyl]-3-nitrobenzenesulfonamide
  • N-[4-(4-methylpiperazin-1-yl)carbonylphenyl]-3-nitro-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0389 0.0438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.3632 0.4087
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.3632 0.4087
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.3632 0.3632
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.3632 0.4087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.3632 0.4087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0389 0.0438
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0271 0.0305
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.3632 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.3632 0.4087
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0389 0.0438
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.8088 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.3632 0.4087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.3632 0.4087
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0079 0.8886 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0271 0.0305
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.3632 0.4087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.3632 0.4087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.3632 0.3632
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0389 0.0438
Brugia malayi Cytochrome P450 family protein 0.0034 0.1893 0.213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.3632 0.4087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.3632 0.4087
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.3632 0.3632
Brugia malayi Cytochrome P450 family protein 0.0035 0.2105 0.2369
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.3632 0.4087
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.0305
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.3632 0.4087
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.1893 1
Schistosoma mansoni nuclear hormone receptor 0.0045 0.3632 0.3632
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.3632 0.4087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.3632 0.4087
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.1893 0.213
Entamoeba histolytica DNA repair and recombination protein, putative 0.0031 0.1546 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.3632 0.4087
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.3632 0.4087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0389 0.0438
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.1893 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.3632 0.4087
Echinococcus granulosus FTZ F1 alpha 0.0045 0.3632 0.4087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0389 0.0438
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.3632 0.3632
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0389 0.0438
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.3632 0.3632
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.1546 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.3632 0.4087
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.3632 0.3632
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Brugia malayi steroid hormone receptor 0.0045 0.3632 0.4087
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.3632 0.4087
Schistosoma mansoni hypothetical protein 0.0031 0.1546 0.1546
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.3632 0.4087
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Schistosoma mansoni thyroid hormone receptor 0.0045 0.3632 0.3632
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0079 0.8886 1
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.3632 0.4087
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.3632 0.4087
Brugia malayi nuclear receptor NHR-88 0.0045 0.3632 0.4087
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.3632 0.4087
Leishmania major cytochrome p450-like protein 0.0034 0.1893 1
Brugia malayi ecdysteroid receptor 0.0045 0.3632 0.4087
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.3632 0.3632
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0271 0.0271
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0271 0.0305
Loa Loa (eye worm) hypothetical protein 0.0024 0.0389 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.3632 0.4087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.3632 0.4087
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.3632 0.4087
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.3632 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.3632 0.3632
Loa Loa (eye worm) hypothetical protein 0.0069 0.7284 0.8197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.3632 0.4087
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0031 0.1546 0.174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.3632 0.4087
Giardia lamblia Rrm3p helicase 0.0031 0.1546 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.3632 0.4087
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0389 0.0389
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.1893 0.213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.3632 0.4087
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.3632 0.4087
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.2105 0.2369
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.3632 0.4087
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.3632 0.4087
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.3632 0.4087
Brugia malayi hypothetical protein 0.0024 0.0389 0.0438
Trypanosoma brucei cytochrome P450, putative 0.0034 0.1893 1
Schistosoma mansoni coup transcription factor 0.0045 0.3632 0.3632
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0389 0.0438
Brugia malayi nuclear hormone receptor 0.0045 0.3632 0.4087
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.3632 1
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.3632 0.4087
Schistosoma mansoni thyroid hormone receptor 0.0045 0.3632 0.3632
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0079 0.8886 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.3632 0.4087
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0271 0.0271
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0389 0.0438
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0079 0.8886 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.3632 0.4087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.3632 0.3632
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.3632 0.4087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.3632 0.4087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.3632 0.4087
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.8088 1
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0271 0.0305
Loa Loa (eye worm) CYP4Cod1 0.0034 0.1893 0.213
Brugia malayi Cytochrome P450 family protein 0.0034 0.1893 0.213
Onchocerca volvulus 0.0045 0.3632 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.3632 0.4087
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0271 0.0305
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.1893 1
Brugia malayi nuclear receptor RXR 0.0024 0.0389 0.0438
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0031 0.1546 0.174
Brugia malayi hypothetical protein 0.0024 0.0389 0.0438

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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