Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cruzipain precursor, putative | 0.0046 | 0.7028 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0046 | 0.7028 | 0.6172 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Plasmodium vivax | vivapain-2 | 0.0046 | 0.7028 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.4473 | 0.4473 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0034 | 0.3016 | 0.1627 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0034 | 0.3016 | 0.1004 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0046 | 0.7028 | 0.6172 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0031 | 0.2236 | 0.3182 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0031 | 0.2236 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0031 | 0.2236 | 0.3182 |
Schistosoma mansoni | brg-1 associated factor | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.2236 | 0.3182 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.5475 | 0.4171 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4473 | 0.2882 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0034 | 0.3016 | 0.4291 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.5475 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.7028 | 0.7028 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.4118 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.5475 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0034 | 0.3016 | 0.3016 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0034 | 0.3016 | 0.4291 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.5475 | 0.779 |
Chlamydia trachomatis | SWIB complex protein | 0.0034 | 0.3016 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4473 | 0.6365 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.1004 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.4118 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.4291 |
Leishmania major | cysteine peptidase A (CPA) | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Onchocerca volvulus | Cathepsin L homolog | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Plasmodium vivax | vivapain-2 | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0046 | 0.7028 | 0.6172 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0046 | 0.7028 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0034 | 0.3016 | 0.3016 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.2236 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0034 | 0.3016 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.5475 | 0.779 |
Loa Loa (eye worm) | fibroinase | 0.0046 | 0.7028 | 0.6172 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | Inositol-1 | 0.0041 | 0.5475 | 0.5475 |
Entamoeba histolytica | cysteine protease, putative | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0031 | 0.2236 | 0.2236 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0046 | 0.7028 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.5475 | 0.6128 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0034 | 0.3016 | 0.3016 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.3016 | 0.4291 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0046 | 0.7028 | 0.6172 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0034 | 0.3016 | 0.4291 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.7028 | 0.6172 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0031 | 0.2236 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 50 % | Anticonvulsant activity in CF1 mouse assessed as protection against 32 mA-current- for 3 secs induced seizure at 100 mg/kg, ip after 0.5 hr by 6Hz psychomotor seizure test | ChEMBL. | 21306800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.