Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4473 | 0.6365 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.5475 | 0.4171 |
Onchocerca volvulus | 0.0034 | 0.3016 | 0.1627 | |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0034 | 0.3016 | 0.4291 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0046 | 0.7028 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.5475 | 0.6128 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0034 | 0.3016 | 0.4291 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.4118 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0034 | 0.3016 | 0.3016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0031 | 0.2236 | 0.3182 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.2236 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0031 | 0.2236 | 0.3182 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0031 | 0.2236 | 0.3182 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0046 | 0.7028 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0031 | 0.2236 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.7028 | 0.7028 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0031 | 0.2236 | 0.2236 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.1004 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Plasmodium vivax | vivapain-2 | 0.0046 | 0.7028 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.4473 | 0.4473 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.5475 | 0.779 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0046 | 0.7028 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0034 | 0.3016 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.3016 | 0.4291 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.4118 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0034 | 0.3016 | 0.4291 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0046 | 0.7028 | 0.6172 |
Brugia malayi | brahma associated protein 60 kDa | 0.0034 | 0.3016 | 0.3016 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Brugia malayi | cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Plasmodium vivax | vivapain-2 | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0046 | 0.7028 | 0.6172 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.5475 | 0.779 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0031 | 0.2236 | 0.3182 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0034 | 0.3016 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.5475 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.7028 | 0.6172 |
Onchocerca volvulus | 0.0046 | 0.7028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4473 | 0.2882 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0046 | 0.7028 | 0.6172 |
Toxoplasma gondii | cathepsin CPL | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.5475 | 0.779 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0046 | 0.7028 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 0.3016 | 0.4291 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0046 | 0.7028 | 0.6172 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Leishmania major | cathepsin L-like protease | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0031 | 0.2236 | 0.2236 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0034 | 0.3016 | 0.1004 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0046 | 0.7028 | 1 |
Brugia malayi | Inositol-1 | 0.0041 | 0.5475 | 0.5475 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Echinococcus granulosus | cathepsin l1 | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.5475 | 0.779 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.5475 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.3016 | 0.4291 |
Brugia malayi | Cathepsin L-like precursor | 0.0046 | 0.7028 | 0.7028 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.5475 | 0.779 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0034 | 0.3016 | 0.4291 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0034 | 0.3016 | 0.3016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.7028 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0046 | 0.7028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0046 | 0.7028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0046 | 0.7028 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0046 | 0.7028 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0046 | 0.7028 | 0.6172 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.5475 | 0.779 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 50 % | Anticonvulsant activity in CF1 mouse assessed as protection against 32 mA-current- for 3 secs induced seizure at 100 mg/kg, ip after 0.5 hr by 6Hz psychomotor seizure test | ChEMBL. | 21306800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.