Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cathepsin CPL | 0.0086 | 0.6495 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0086 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0086 | 0.6495 | 0.5582 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0086 | 0.6495 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.2067 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0086 | 0.6495 | 0.5582 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0086 | 0.6495 | 0.6495 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Loa Loa (eye worm) | ctsf protein | 0.0086 | 0.6495 | 0.5582 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Echinococcus granulosus | cathepsin l1 | 0.0058 | 0.2067 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.2067 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0086 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0058 | 0.2067 | 0.2067 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0058 | 0.2067 | 0.3182 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0086 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0086 | 0.6495 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0086 | 0.6495 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0086 | 0.6495 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0058 | 0.2067 | 0.2067 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0086 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0086 | 0.6495 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Loa Loa (eye worm) | cysteine protease | 0.0086 | 0.6495 | 0.5582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0058 | 0.2067 | 0.2067 |
Onchocerca volvulus | Cathepsin F homolog | 0.0086 | 0.6495 | 0.5582 |
Onchocerca volvulus | Cathepsin L homolog | 0.0086 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0086 | 0.6495 | 0.5582 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0086 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0086 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.2067 | 0.2067 |
Loa Loa (eye worm) | fibroinase | 0.0086 | 0.6495 | 0.5582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0086 | 0.6495 | 0.6495 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0086 | 0.6495 | 0.5582 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0058 | 0.2067 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0086 | 0.6495 | 0.6495 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.2067 | 0.2067 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.6495 | 0.6495 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0086 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0086 | 0.6495 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0086 | 0.6495 | 1 |
Onchocerca volvulus | 0.0085 | 0.6314 | 0.5354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.