Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.006 | 0.3699 | 0.3639 |
Echinococcus granulosus | cysteine protease | 0.0046 | 0.2058 | 0.2792 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0046 | 0.2058 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.3699 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Loa Loa (eye worm) | cysteine protease | 0.009 | 0.7216 | 0.719 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.3699 | 0.5061 |
Onchocerca volvulus | 0.009 | 0.7216 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.009 | 0.7216 | 0.9793 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.009 | 0.7216 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7216 | 0.719 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7216 | 0.719 |
Echinococcus multilocularis | cysteine protease | 0.009 | 0.7216 | 0.9793 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.009 | 0.7216 | 0.9793 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.009 | 0.7216 | 0.9793 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0091 | 0.7368 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7216 | 0.719 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.009 | 0.7216 | 0.5582 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.006 | 0.3699 | 0.3639 |
Loa Loa (eye worm) | fibroinase | 0.009 | 0.7216 | 0.719 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.009 | 0.7216 | 0.9793 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2058 | 0.2058 |
Brugia malayi | Papain family cysteine protease containing protein | 0.009 | 0.7216 | 0.719 |
Echinococcus granulosus | cathepsin L | 0.0046 | 0.2058 | 0.2792 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Onchocerca volvulus | 0.009 | 0.7216 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.7216 | 0.719 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.2058 | 0.1982 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.006 | 0.3699 | 0.3699 |
Schistosoma mansoni | cathepsin s | 0.003 | 0.0094 | 0.0094 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.006 | 0.3699 | 0.3182 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0091 | 0.7368 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0046 | 0.2058 | 0.2757 |
Onchocerca volvulus | 0.009 | 0.7216 | 0.5582 | |
Toxoplasma gondii | cathepsin CPL | 0.009 | 0.7216 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3699 | 0.3639 |
Onchocerca volvulus | 0.009 | 0.7216 | 0.5582 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.006 | 0.3699 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7216 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.009 | 0.7216 | 0.9793 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.009 | 0.7216 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.7216 | 1 |
Onchocerca volvulus | 0.0088 | 0.7072 | 0.5354 | |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7216 | 0.719 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.009 | 0.7216 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.009 | 0.7216 | 0.9793 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Plasmodium vivax | vivapain-2 | 0.009 | 0.7216 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.3699 | 0.3639 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2058 | 0.2058 |
Brugia malayi | Cathepsin L-like precursor | 0.006 | 0.3699 | 0.3639 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.009 | 0.7216 | 0.5582 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0046 | 0.2058 | 0.1982 |
Echinococcus granulosus | cathepsin l1 | 0.006 | 0.3699 | 0.502 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7216 | 0.719 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.7216 | 0.7216 |
Onchocerca volvulus | Cathepsin L homolog | 0.009 | 0.7216 | 0.5582 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.009 | 0.7216 | 0.719 |
Echinococcus multilocularis | cathepsin L | 0.0046 | 0.2058 | 0.2792 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0046 | 0.2058 | 0.2757 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.009 | 0.7216 | 0.9793 |
Onchocerca volvulus | 0.009 | 0.7216 | 0.5582 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.009 | 0.7216 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.009 | 0.7216 | 0.719 |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.7216 | 0.7216 |
Leishmania major | cysteine peptidase A (CPA) | 0.009 | 0.7216 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.009 | 0.7216 | 1 |
Plasmodium vivax | vivapain-3 | 0.0046 | 0.2058 | 0.2757 |
Echinococcus multilocularis | cysteine protease | 0.009 | 0.7216 | 0.9793 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.009 | 0.7216 | 1 |
Onchocerca volvulus | 0.009 | 0.7216 | 0.5582 | |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.7216 | 0.719 |
Plasmodium vivax | vivapain-1 | 0.0046 | 0.2058 | 0.2757 |
Plasmodium vivax | unspecified product | 0.0046 | 0.2058 | 0.2757 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0046 | 0.2058 | 0.2757 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.009 | 0.7216 | 0.719 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0046 | 0.2058 | 0.2058 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Onchocerca volvulus | 0.009 | 0.7216 | 0.5582 | |
Leishmania major | cathepsin L-like protease | 0.009 | 0.7216 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0046 | 0.2058 | 0.2792 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0091 | 0.7368 | 0.7368 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3699 | 0.3639 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0046 | 0.2058 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3699 | 0.3639 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.009 | 0.7216 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 80 % | Inhibition of human recombinant NR1/NR2B receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
Activity (binding) | = 80 % | Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
IC50 (binding) | = 3.8 | Inhibition of human recombinant NR1/NR2B receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
IC50 (binding) | = 4.6 | Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | ChEMBL. | 21334205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.