Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8743 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0949 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4864 | 0.5563 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4864 | 0.5563 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0901 | 0.9494 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0949 | 0.1086 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0949 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0949 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0949 | 0.1086 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0949 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0949 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0949 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0949 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8743 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0949 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4864 | 0.5563 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0949 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.