Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0304 | 0.0952 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0442 | 0.2992 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0304 | 0.0952 | 0.0958 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0911 | 0.9937 | 0.9937 |
Onchocerca volvulus | 0.0442 | 0.2992 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.0304 | 0.0952 | 0.0958 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0442 | 0.2992 | 0.301 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0442 | 0.2992 | 0.2992 |
Echinococcus multilocularis | cysteine protease | 0.0442 | 0.2992 | 0.301 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0304 | 0.0952 | 0.0958 |
Onchocerca volvulus | 0.0442 | 0.2992 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0352 | 0.1664 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0304 | 0.0952 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0442 | 0.2992 | 0.301 |
Brugia malayi | Cathepsin L-like precursor | 0.0442 | 0.2992 | 0.301 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0304 | 0.0952 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.9937 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0442 | 0.2992 | 0.227 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0778 | 0.796 | 0.796 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0304 | 0.0952 | 0.3182 |
Entamoeba histolytica | cysteine protease, putative | 0.0442 | 0.2992 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0442 | 0.2992 | 0.227 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0442 | 0.2992 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0442 | 0.2992 | 0.301 |
Echinococcus granulosus | cathepsin b | 0.0911 | 0.9937 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0442 | 0.2992 | 0.227 |
Onchocerca volvulus | Cathepsin L homolog | 0.0442 | 0.2992 | 1 |
Onchocerca volvulus | 0.0442 | 0.2992 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0442 | 0.2992 | 0.301 |
Giardia lamblia | Cathepsin B precursor | 0.0352 | 0.1664 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0442 | 0.2992 | 0.301 |
Brugia malayi | Cathepsin L-like precursor | 0.0442 | 0.2992 | 0.301 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Plasmodium vivax | vivapain-2 | 0.0442 | 0.2992 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0442 | 0.2992 | 0.227 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0304 | 0.0952 | 0.0958 |
Onchocerca volvulus | 0.0442 | 0.2992 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0442 | 0.2992 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0911 | 0.9937 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0911 | 0.9937 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0442 | 0.2992 | 0.301 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0352 | 0.1664 | 0.1664 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0442 | 0.2992 | 0.227 |
Leishmania major | cysteine peptidase A (CPA) | 0.0442 | 0.2992 | 0.1592 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0442 | 0.2992 | 0.301 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0442 | 0.2992 | 0.301 |
Onchocerca volvulus | 0.0442 | 0.2992 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0442 | 0.2992 | 0.301 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0304 | 0.0952 | 0.0958 |
Onchocerca volvulus | 0.0442 | 0.2992 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0442 | 0.2992 | 0.1592 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0911 | 0.9937 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0911 | 0.9937 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0442 | 0.2992 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0442 | 0.2992 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0911 | 0.9937 | 1 |
Leishmania major | cathepsin L-like protease | 0.0442 | 0.2992 | 0.1592 |
Brugia malayi | Cathepsin L-like precursor | 0.0442 | 0.2992 | 0.301 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0352 | 0.1664 | 0.1664 |
Loa Loa (eye worm) | cathepsin B | 0.0352 | 0.1664 | 0.0793 |
Echinococcus multilocularis | cathepsin b | 0.0911 | 0.9937 | 1 |
Onchocerca volvulus | 0.0442 | 0.2992 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0442 | 0.2992 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0442 | 0.2992 | 0.301 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0442 | 0.2992 | 0.301 |
Leishmania major | cathepsin L-like protease | 0.0442 | 0.2992 | 0.1592 |
Plasmodium vivax | vivapain-2 | 0.0442 | 0.2992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.2992 | 0.227 |
Echinococcus granulosus | cathepsin l1 | 0.0442 | 0.2992 | 0.301 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0352 | 0.1664 | 0.5564 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Leishmania major | cathepsin L-like protease | 0.0442 | 0.2992 | 0.1592 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0575 | 0.4969 | 0.4969 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0442 | 0.2992 | 0.301 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0352 | 0.1664 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0911 | 0.9937 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0352 | 0.1664 | 0.1675 |
Echinococcus granulosus | cathepsin b | 0.0911 | 0.9937 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0442 | 0.2992 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0442 | 0.2992 | 0.301 |
Leishmania major | cathepsin L-like protease | 0.0442 | 0.2992 | 0.1592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.