Target list

Search results for query: Weighted ranking of Mtb targets based on gene essentiality and expression during persistence for PLOS-NTD

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  • Score for genes in query #2 (Hasan 2006 persistence, revised):
  • Score for genes in query #5 (Mtu PDB structures): 20
  • Score for genes in query #10 (Mtb weighted list for persistence expression score as in Murphy-Brown data): weighted list
  • Score for genes in query #9 (Mtb weighted list for gene attenuation score as in Murphy-Brown data): weighted list
  • Score for genes in query #8 (Mtu all proteins): 1

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2253 records found | Showing page 2 of 91 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv1738   OG5_239144   Conserved protein 397
M. tuberculosis   Rv1734c     No group Conserved hypothetical protein 396
M. tuberculosis   Rv0569   OG5_239117   Conserved protein 394
M. tuberculosis   Rv3616c   OG5_237581   ESX-1 secretion-associated protein A, EspA 392
M. tuberculosis   Rv0251c   OG5_126935   Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A) 391
M. tuberculosis   Rv0190   OG5_136234   Conserved protein 391
M. tuberculosis   Rv2694c     No group Conserved protein 382
M. tuberculosis   Rv0872c   OG5_129879   PE-PGRS family protein PE_PGRS15 378
M. tuberculosis   Rv3287c     No group Anti-sigma factor RsbW (sigma negative effector) 378
M. tuberculosis   Rv2031c   OG5_126935   Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) 373
M. tuberculosis   Rv0137c   OG5_126847   Probable peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide ... 373
M. tuberculosis   Rv0116c   OG5_237840   Probable L,D-transpeptidase LdtA 365
M. tuberculosis   Rv0197   OG5_175709   Possible oxidoreductase 365
M. tuberculosis   Rv1404   OG5_160441   Probable transcriptional regulatory protein 362
M. tuberculosis   Rv0467   OG5_129572   Isocitrate lyase Icl (isocitrase) (isocitratase) 361
M. tuberculosis   Rv1285   OG5_137554   Probable sulfate adenylyltransferase subunit 2 CysD 357
M. tuberculosis   Rv3132c   OG5_153508   Two component sensor histidine kinase DevS 357
M. tuberculosis   Rv0810c   OG5_237775   Conserved hypothetical protein 348
M. tuberculosis   Rv2295   OG5_230482   Conserved hypothetical protein 348
M. tuberculosis   Rv2029c   OG5_132575   6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 347
M. tuberculosis   Rv1221   OG5_132054   Alternative RNA polymerase sigma factor SigE 340
M. tuberculosis   Rv1493   OG5_130968   Probable methylmalonyl-CoA mutase large subunit MutB (MCM) 339
M. tuberculosis   Rv2036   OG5_239152   Conserved hypothetical protein 339
M. tuberculosis   Rv2710   OG5_237645   RNA polymerase sigma factor SigB 337
M. tuberculosis   Rv2878c   OG5_129566   Soluble secreted antigen Mpt53 precursor 333

Showing page 2 (records 26-50) of 91