Target list

Search results for query: Weighted ranking of Mtb targets based on gene essentiality and expression during persistence for PLOS-NTD

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  • Score for genes in query #9 (Mtb weighted list for gene attenuation score as in Murphy-Brown data): weighted list
  • Score for genes in query #8 (Mtu all proteins): 1
  • Score for genes in query #10 (Mtb weighted list for persistence expression score as in Murphy-Brown data): weighted list
  • Score for genes in query #5 (Mtu PDB structures): 20
  • Score for genes in query #2 (Hasan 2006 persistence, revised):

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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2253 records found | Showing page 3 of 91 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0046c   OG5_139953   myo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-gluc ... 332
M. tuberculosis   Rv3371   OG5_133846   Possible triacylglycerol synthase (diacylglycerol acyltransferase) 332
M. tuberculosis   Rv3484   OG5_213861   Possible conserved protein CpsA 331
M. tuberculosis   Rv3380c   OG5_128670   Probable transposase 331
M. tuberculosis   Rv1405c   OG5_176030   Putative methyltransferase 327
M. tuberculosis   Rv3776   OG5_166864   Conserved hypothetical protein 326
M. tuberculosis   Rv3801c   OG5_127582   Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthas ... 325
M. tuberculosis   Rv2358   OG5_155588   Probable transcriptional regulatory protein SmtB (probably ArsR-family) 324
M. tuberculosis   Rv0834c   OG5_129879   PE-PGRS family protein PE_PGRS14 322
M. tuberculosis   Rv1806   OG5_132981   PE family protein PE20 322
M. tuberculosis   Rv0082   OG5_143851   Probable oxidoreductase 322
M. tuberculosis   Rv2631   OG5_127467   Conserved hypothetical protein 322
M. tuberculosis   Rv1286   OG5_168022   Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + ... 321
M. tuberculosis   Rv0559c   OG5_237782   Possible conserved secreted protein 321
M. tuberculosis   Rv1894c   OG5_141344   Conserved hypothetical protein 321
M. tuberculosis   Rv0752c   OG5_136059   Probable acyl-CoA dehydrogenase FadE9 320
M. tuberculosis   Rv0827c   OG5_129305   Metal sensor transcriptional regulator KmtR (ArsR-SmtB family) 319
M. tuberculosis   Rv3572     No group Unknown protein 318
M. tuberculosis   Rv2500c   OG5_128729   Possible acyl-CoA dehydrogenase FadE19 (MMGC) 315
M. tuberculosis   Rv3437     No group Possible conserved transmembrane protein 314
M. tuberculosis   Rv2466c   OG5_237696   Conserved protein 312
M. tuberculosis   Rv3615c   OG5_237582   ESX-1 secretion-associated protein EspC 308
M. tuberculosis   Rv3406   OG5_129515   Probable dioxygenase 307
M. tuberculosis   Rv2359   OG5_130371   Probable zinc uptake regulation protein Zur 304
M. tuberculosis   Rv0455c   OG5_237795   Conserved protein 301

Showing page 3 (records 51-75) of 91