Target list

Search results for query: PLoS NTD Query 5 (M. tuberculosis)

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  • Score for genes in query #68 (Mtb any genetic validation): 50
  • Score for genes in query #71 (Mtb Compd desirability >0.3): 35
  • Score for genes in query #70 (Mtb dindex >=0.6): 35
  • Score for genes in query #67 (Mtb in Mle): 25
  • Score for genes in query #65 (Mtb modbase): 30
  • Score for genes in query #63 (Mtb no TM domain): 20
  • Score for genes in query #69 (Mtb any essentiality evidence): 50
  • Score for genes in query #66 (Mtb not in humans): 25
  • Score for genes in query #72 (Mtb assayable): 35
  • Score for genes in query #61 (Mtb Pubmed): 35
  • Score for genes in query #62 (Mtb mwt <100kDa): 20
  • Score for genes in query #64 (Mtb PDB): 50
  • Score for genes in query #60 (Mtb enz (EC + func. Categ.)): 100
  • Score for genes in query #74 (Mtb all proteins): 1

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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2253 records found | Showing page 4 of 91 (records 76-100) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv1131   OG5_128590   Probable methylcitrate synthase PrpC 316
M. tuberculosis   Rv3214   OG5_132095   Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-depende ... 316
M. tuberculosis   Rv3411c   OG5_126887   Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosi ... 316
M. tuberculosis   Rv3010c   OG5_126758   Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 316
M. tuberculosis   Rv1437   OG5_126776   Probable phosphoglycerate kinase Pgk 316
M. tuberculosis   Rv1649   OG5_127036   Probable phenylalanyl-tRNA synthetase, alpha chain PheS 316
M. tuberculosis   Rv0009   OG5_128211   Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (r ... 316
M. tuberculosis   Rv0248c   OG5_126927   Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 316
M. tuberculosis   Rv1106c   OG5_133610   3-beta-hydroxysteroid dehydrogenase 316
M. tuberculosis   Rv1544   OG5_126812   Possible ketoacyl reductase 316
M. tuberculosis   Rv2182c   OG5_126904   1-acylglycerol-3-phosphate O-acyltransferase 316
M. tuberculosis   Rv0432   OG5_127584   Periplasmic superoxide dismutase [Cu-Zn] SodC 316
M. tuberculosis   Rv1848   OG5_139588   Urease gamma subunit UreA (urea amidohydrolase) 316
M. tuberculosis   Rv1850   OG5_132452   Urease alpha subunit UreC (urea amidohydrolase) 316
M. tuberculosis   Rv2448c   OG5_126723   Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ... 316
M. tuberculosis   Rv3809c   OG5_139595   UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleoti ... 311
M. tuberculosis   Rv0467   OG5_129572   Isocitrate lyase Icl (isocitrase) (isocitratase) 311
M. tuberculosis   Rv0983   OG5_126815   Probable serine protease PepD (serine proteinase) (MTB32B) 311
M. tuberculosis   Rv1380   OG5_128535   Probable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylas ... 311
M. tuberculosis   Rv2538c   OG5_127183   3-dehydroquinate synthase AroB 306
M. tuberculosis   Rv1568   OG5_128068   Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 306
M. tuberculosis   Rv0766c   OG5_132455   Probable cytochrome P450 123 Cyp123 306
M. tuberculosis   Rv2266   OG5_132455   Probable cytochrome P450 124 Cyp124 306
M. tuberculosis   Rv2268c   OG5_132455   Probable cytochrome P450 128 Cyp128 306
M. tuberculosis   Rv3518c   OG5_132455   Probable cytochrome P450 monooxygenase 142 Cyp142 306

Showing page 4 (records 76-100) of 91