Target list

Search results for query: PLoS NTD Query 5 (M. tuberculosis)

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  • Score for genes in query #71 (Mtb Compd desirability >0.3): 35
  • Score for genes in query #69 (Mtb any essentiality evidence): 50
  • Score for genes in query #65 (Mtb modbase): 30
  • Score for genes in query #72 (Mtb assayable): 35
  • Score for genes in query #66 (Mtb not in humans): 25
  • Score for genes in query #61 (Mtb Pubmed): 35
  • Score for genes in query #68 (Mtb any genetic validation): 50
  • Score for genes in query #74 (Mtb all proteins): 1
  • Score for genes in query #60 (Mtb enz (EC + func. Categ.)): 100
  • Score for genes in query #67 (Mtb in Mle): 25
  • Score for genes in query #63 (Mtb no TM domain): 20
  • Score for genes in query #70 (Mtb dindex >=0.6): 35
  • Score for genes in query #64 (Mtb PDB): 50
  • Score for genes in query #62 (Mtb mwt <100kDa): 20

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2253 records found | Showing page 3 of 91 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0006   OG5_129568   DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisome ... 326
M. tuberculosis   Rv2121c   OG5_129102   ATP phosphoribosyltransferase HisG 326
M. tuberculosis   Rv0373c   OG5_127252   Probable carbon monoxyde dehydrogenase (large chain) 326
M. tuberculosis   Rv3913   OG5_127532   Probable thioredoxin reductase TrxB2 (TRXR) (TR) 326
M. tuberculosis   Rv1654   OG5_130618   Probable acetylglutamate kinase ArgB 321
M. tuberculosis   Rv2178c   OG5_130802   3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phen ... 321
M. tuberculosis   Rv2068c   OG5_143180   Class a beta-lactamase BlaC 321
M. tuberculosis   Rv1547   OG5_132143   Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 321
M. tuberculosis   Rv3804c   OG5_210859   Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protei ... 321
M. tuberculosis   Rv1886c   OG5_237749   Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B ... 321
M. tuberculosis   Rv0129c   OG5_237839   Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transfe ... 321
M. tuberculosis   Rv3803c   OG5_237550   Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG ... 321
M. tuberculosis   Rv1018c   OG5_131193   Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 321
M. tuberculosis   Rv1295   OG5_130923   Threonine synthase ThrC (ts) 321
M. tuberculosis   Rv2780   OG5_127241   Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43) 316
M. tuberculosis   Rv0429c   OG5_128237   Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 316
M. tuberculosis   Rv2579   OG5_158622   Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 316
M. tuberculosis   Rv1070c   OG5_128562   Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydrata ... 316
M. tuberculosis   Rv3795   OG5_166834   Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylin ... 316
M. tuberculosis   Rv3793   OG5_166834   Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylin ... 316
M. tuberculosis   Rv3556c   OG5_147360   Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase) 316
M. tuberculosis   Rv0886   OG5_217326   Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (fer ... 316
M. tuberculosis   Rv1552   OG5_126927   Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) ... 316
M. tuberculosis   Rv1553   OG5_126893   Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) ... 316
M. tuberculosis   Rv1098c   OG5_127258   Probable fumarase Fum (fumarate hydratase) 316

Showing page 3 (records 51-75) of 91