Target list

Search results for query: PLoS NTD Query 8 (T. cruzi)

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  • Score for genes in query #6 (> 3 paralogs): -30
  • Score for genes in query #5 (any evidence of essentiality): 50
  • Score for genes in query #15 (tcruzi assay available): 30
  • Score for genes in query #1 (amastigote expression >= 2 spectra / 2 peptides): 20
  • Score for genes in query #4 (3D model): 10
  • Score for genes in query #2 (is enzyme): 20
  • Score for genes in query #14 (tcruzi reagent availability): 30
  • Score for genes in query #12 (tcruzi in leish): 90
  • Score for genes in query #3 (3D structure): 10
  • Score for genes in query #9 (low molecular weight (< 100 kDa)): 25
  • Score for genes in query #8 (bibrefs): 25
  • Score for genes in query #10 (tcruzi all genes): 1
  • Score for genes in query #7 (druggability > .5): 60
  • Score for genes in query #13 (tcruzi not in tbrucei): 150
  • Imported: from "tcruzi targets shared with leishmania, absent in tbrucei", posted by Fernan Aguero
  • Score for genes in query #11 (tcruzi not in humans): 80

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18628 records found | Showing page 744 of 746 (records 18576-18600) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.509317.50   OG5_129165   dolichyl-P-Man:GDP-Man7GlcNAc2-PP-dolichyl alpha-1,6-mannosyltransferase, putati ... 26
T. cruzi   TcCLB.509601.130   OG5_154369   LicD family, putative 26
T. cruzi   TcCLB.508515.90   OG5_133713   Domain of unknown function (DUF4505), putative 26
T. cruzi   TcCLB.507093.140   OG5_129008   hypothetical protein, conserved 26
T. cruzi   TcCLB.510187.74   OG5_127561   short-chain dehydrogenase, putative 26
T. cruzi   TcCLB.509065.170   OG5_128472   Protein of unknown function (DUF544), putative 26
T. cruzi   TcCLB.509167.200   OG5_128472   Protein of unknown function (DUF544), putative 26
T. cruzi   TcCLB.506811.100   OG5_130150   Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1, putative 26
T. cruzi   TcCLB.508239.40   OG5_130492   palmitoyl acyltransferase 8, putative 26
T. cruzi   TcCLB.510861.30   OG5_129554   hypothetical protein, conserved 26
T. cruzi   TcCLB.511509.40   OG5_134569   NUDIX hydrolase domain-like domain-containing protein 26
T. cruzi   TcCLB.511751.120   OG5_127094   aldehyde dehydrogenase family, putative 26
T. cruzi   TcCLB.507649.10   OG5_129554   hypothetical protein, conserved 26
T. cruzi   TcCLB.506303.130   OG5_130150   Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1, putative 26
T. cruzi   TcCLB.507641.130   OG5_131353   N-terminal glutamine amidase, putative 26
T. cruzi   TcCLB.504153.70   OG5_131073   Tubulin-tyrosine ligase family, putative 26
T. cruzi   TcCLB.508793.30   OG5_130492   palmitoyl acyltransferase 8, putative 26
T. cruzi   TcCLB.510533.180   OG5_160612   microtubule-associated protein 1A/1B, light chain 3, putative 26
T. cruzi   TcCLB.509767.130   OG5_154369   LicD family, putative 26
T. cruzi   TcCLB.511727.300   OG5_129198   GDP-L-fucose synthetase, putative 26
T. cruzi   TcCLB.509099.100   OG5_158003   MIZ/SP-RING zinc finger, putative 26
T. cruzi   TcCLB.509169.30   OG5_134569   NUDIX hydrolase domain-like domain-containing protein 26
T. cruzi   TcCLB.510825.30   OG5_127548   lysosomal/endosomal membrane protein p67 26
T. cruzi   TcCLB.511821.160   OG5_160612   microtubial binding protein, putative 26
T. cruzi   TcCLB.508641.110   OG5_133713   Domain of unknown function (DUF4505), putative 26

Showing page 744 (records 18576-18600) of 746