Target list

Search results for query: PLoS NTD Query 8 (T. cruzi)

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  • Score for genes in query #11 (tcruzi not in humans): 80
  • Score for genes in query #12 (tcruzi in leish): 90
  • Score for genes in query #8 (bibrefs): 25
  • Score for genes in query #1 (amastigote expression >= 2 spectra / 2 peptides): 20
  • Imported: from "tcruzi targets shared with leishmania, absent in tbrucei", posted by Fernan Aguero
  • Score for genes in query #15 (tcruzi assay available): 30
  • Score for genes in query #9 (low molecular weight (< 100 kDa)): 25
  • Score for genes in query #10 (tcruzi all genes): 1
  • Score for genes in query #3 (3D structure): 10
  • Score for genes in query #13 (tcruzi not in tbrucei): 150
  • Score for genes in query #6 (> 3 paralogs): -30
  • Score for genes in query #5 (any evidence of essentiality): 50
  • Score for genes in query #2 (is enzyme): 20
  • Score for genes in query #4 (3D model): 10
  • Score for genes in query #7 (druggability > .5): 60
  • Score for genes in query #14 (tcruzi reagent availability): 30

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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18628 records found | Showing page 745 of 746 (records 18601-18625) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.504221.9   OG5_139131   membrane associated protein, putative 11
T. cruzi   TcCLB.503735.49   OG5_152065   hypothetical protein, conserved 11
T. cruzi   TcCLB.507023.10   OG5_130626   epsilon-adaptin, putative 11
T. cruzi   TcCLB.506297.40   OG5_163752   hypothetical protein, conserved 11
T. cruzi   TcCLB.508917.30   OG5_132329   kinesin, putative 11
T. cruzi   TcCLB.506559.100   OG5_126561   multidrug resistance-associated protein, putative 11
T. cruzi   TcCLB.510101.290   OG5_163752   hypothetical protein, conserved 11
T. cruzi   TcCLB.510861.70   OG5_152065   hypothetical protein, conserved 11
T. cruzi   TcCLB.506617.70   OG5_130000   glycosylphosphatidylinositol-specific phospholipase C 6
T. cruzi   TcCLB.504411.20   OG5_128186   divalent cation tolerance protein, putative 6
T. cruzi   TcCLB.506489.59   OG5_128186   divalent cation tolerance protein, putative 6
T. cruzi   TcCLB.509317.20   OG5_128665   esterase, putative 6
T. cruzi   TcCLB.506821.30   OG5_130000   glycosylphosphatidylinositol-specific phospholipase C 6
T. cruzi   TcCLB.507041.120   OG5_130000   variant-surface-glycoprotein phospholipase C, putative 6
T. cruzi   TcCLB.505193.50   OG5_133707   hypothetical protein 6
T. cruzi   TcCLB.504717.10   OG5_128186   divalent cation tolerance protein, putative 6
T. cruzi   TcCLB.508807.5   OG5_130000   VSG lipase 6
T. cruzi   TcCLB.508233.50   OG5_130000   vsglipase, putative 6
T. cruzi   TcCLB.511621.220   OG5_128665   esterase, putative 6
T. cruzi   TcCLB.511033.29   OG5_165173   hypothetical protein 1
T. cruzi   TcCLB.511751.200   OG5_130626   epsilon-adaptin, putative 1
T. cruzi   TcCLB.505009.20   OG5_128186   divalent cation tolerance protein, putative -4
T. cruzi   TcCLB.505171.20   OG5_132347   hypothetical protein -4
T. cruzi   TcCLB.508765.30   OG5_130000   VSG lipase -4
T. cruzi   TcCLB.504741.140   OG5_128665   esterase, putative -4

Showing page 745 (records 18601-18625) of 746