pI: 4.5194 |
Length (AA): 329 |
MW (Da): 34871 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 329 | 1aw5 (A) | 1 | 339 | 36.00 | 0 | 1 | 1.3516 | 0.02 |
1 | 328 | 5lzl (A) | 1 | 332 | 50.00 | 0 | 1 | 1.57556 | -0.34 |
5 | 328 | 1w5q (A) | 9 | 333 | 48.00 | 0 | 1 | 1.5614 | -0.56 |
8 | 328 | 3obk (A) | 20 | 341 | 44.00 | 0 | 1 | 1.53328 | -0.64 |
9 | 326 | 1l6s (A) | 5 | 318 | 48.00 | 0 | 1 | 1.58047 | -0.57 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127486)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G69740 | putative delta-aminolevulinic acid dehydratase |
Babesia bovis | BBOV_II001120 | delta-aminolevulinic acid dehydratase, putative |
Candida albicans | CaO19.8517 | porphobilinogen synthase |
Candida albicans | CaO19.898 | porphobilinogen synthase |
Chlamydia trachomatis | CT_633 | delta-aminolevulinic acid dehydratase |
Dictyostelium discoideum | DDB_G0269444 | delta-aminolevulinate dehydratase |
Drosophila melanogaster | Dmel_CG10335 | Porphobilinogen synthase |
Escherichia coli | b0369 | 5-aminolevulinate dehydratase (porphobilinogen synthase) |
Echinococcus granulosus | EgrG_000471300 | delta aminolevulinic acid dehydratase |
Echinococcus multilocularis | EmuJ_000471300 | delta aminolevulinic acid dehydratase |
Homo sapiens | ENSG00000148218 | aminolevulinate dehydratase |
Mycobacterium leprae | ML2419c | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) |
Mus musculus | ENSMUSG00000028393 | aminolevulinate, delta-, dehydratase |
Mycobacterium tuberculosis | Rv0512 | Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) |
Mycobacterium ulcerans | MUL_4601 | delta-aminolevulinic acid dehydratase |
Neospora caninum | NCLIV_008230 | Delta-aminolevulinic acid dehydratase (EC 4.2.1.24), related |
Oryza sativa | 4341997 | Os06g0704600 |
Plasmodium berghei | PBANKA_1304100 | porphobilinogen synthase, putative |
Plasmodium falciparum | PF3D7_1440300 | porphobilinogen synthase |
Plasmodium knowlesi | PKNH_1242100 | porphobilinogen synthase, putative |
Plasmodium vivax | PVX_118480 | delta-aminolevulinic acid dehydratase, putative |
Plasmodium yoelii | PY04302 | porphobilinogen synthase, putative |
Saccharomyces cerevisiae | YGL040C | porphobilinogen synthase HEM2 |
Schistosoma japonicum | Sjp_0075570 | ko:K01698 porphobilinogen synthase [EC4.2.1.24], putative |
Schistosoma mansoni | Smp_045810.1 | porphobilinogen synthase |
Schistosoma mansoni | Smp_045810.2 | porphobilinogen synthase |
Schmidtea mediterranea | mk4.029516.02 | |
Schmidtea mediterranea | mk4.000123.05 | Delta-aminolevulinic acid dehydratase |
Toxoplasma gondii | TGME49_253900 | parasite porphobilinogen synthase PBGS |
Wolbachia endosymbiont of Brugia malayi | Wbm0373 | delta-aminolevulinic acid dehydratase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b0369 | Escherichia coli | essential | goodall |
YGL040C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1304100 | Plasmodium berghei | Essential | plasmo |
TGME49_253900 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | porphobilinogen synthase | Compounds | References |
Wolbachia sp. subsp. Brugia malayi (strain TRS) | Delta-aminolevulinic acid dehydratase | Compounds | References |
Escherichia coli | 5-aminolevulinate dehydratase (porphobilinogen synthase) | Compounds | References |
Pisum sativum | Delta-aminolevulinic acid dehydratase, chloroplastic | Compounds | References |
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) | Delta-aminolevulinic acid dehydratase | Compounds | References |