Detailed view for Rv1987

Basic information

TDR Targets ID: 980968
Mycobacterium tuberculosis, Possible chitinase
Source Database / ID:  Tuberculist 

pI: 10.0479 | Length (AA): 142 | MW (Da): 14919 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00553  

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0030247   polysaccharide binding  
GO:0030246   carbohydrate binding  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 142 1exg (A) 1 108 39.00 0 0.99 1.22835 -0.05
37 142 2rtt (A) 1 102 42.00 0 0.65 1.16758 0.01
38 142 3ndz (E) 381 485 29.00 0.00000000047 0.98 1.16944 -0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126929)

Species Accession Gene Product
Arabidopsis thaliana AT4G19760   Glycosyl hydrolase family protein with chitinase insertion domain
Arabidopsis thaliana AT4G19720   Glycosyl hydrolase family protein with chitinase insertion domain
Arabidopsis thaliana AT4G19820   Glycosyl hydrolase family protein with chitinase insertion domain
Arabidopsis thaliana AT4G19800   Glycosyl hydrolase family protein with chitinase insertion domain
Arabidopsis thaliana AT4G19770   Glycosyl hydrolase family protein with chitinase insertion domain
Arabidopsis thaliana AT4G19750   Glycosyl hydrolase family protein with chitinase insertion domain
Arabidopsis thaliana AT4G19810   Class V chitinase
Brugia malayi Bm1_28620   Endochitinase
Brugia malayi Bm1_06755   endochitinase
Brugia malayi Bm1_17035   endochitinase
Candida albicans CaO19.1515   chitinase similar to Ajellomyces capsulatus CTS1
Candida albicans CaO19.9090   chitinase similar to Ajellomyces capsulatus CTS1
Caenorhabditis elegans CELE_C04F6.3   Protein CHT-1
Drosophila melanogaster Dmel_CG1869   CG1869 gene product from transcript CG1869-RA
Entamoeba histolytica EHI_109890   chitinase, putative
Homo sapiens ENSG00000133063   chitinase 1 (chitotriosidase)
Homo sapiens ENSG00000134216   chitinase, acidic
Leishmania donovani LdBPK_160790.1   chitinase
Leishmania infantum LinJ.16.0790   chitinase
Leishmania major LmjF.16.0790   chitinase
Loa Loa (eye worm) LOAG_14219   chitinase I
Loa Loa (eye worm) LOAG_09587   microfilarial chitinase
Loa Loa (eye worm) LOAG_12719   hypothetical protein
Loa Loa (eye worm) LOAG_12924   cuticular endochitinase
Mus musculus ENSMUSG00000062778   chitinase, acidic 1
Mus musculus 229687   chitinase-like 5
Mus musculus ENSMUSG00000026450   chitinase 1 (chitotriosidase)
Mycobacterium tuberculosis Rv1987   Possible chitinase
Mycobacterium ulcerans MUL_0371   chitinase/cellulase
Mycobacterium ulcerans MUL_2210   chitinase/cellulase
Oryza sativa 4335610   Os04g0376400
Oryza sativa 4350476   Os11g0462100
Onchocerca volvulus OVOC12568   Putative endochitinase
Onchocerca volvulus OVOC9515   Putative endochitinase
Onchocerca volvulus OVOC3520   Putative endochitinase
Onchocerca volvulus OVOC12569   Putative endochitinase
Onchocerca volvulus OVOC9499   Putative endochitinase
Saccharomyces cerevisiae YDR371W   Cts2p

Essentiality

Rv1987 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C04F6.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus chitinase, acidic 1 Compounds References
Serratia marcescens Chitinase A Compounds References
Aspergillus fumigatus Chitinase Compounds References
Homo sapiens chitinase 1 (chitotriosidase) Compounds References
Onchocerca volvulus Chitinase Compounds References
Serratia marcescens Chitinase B Compounds References
Homo sapiens chitinase, acidic Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0461 0.7149 0.5
0.0933 0.2881 1
0.0795 0.6239 1
0.0065 0.2943 0.5
0.0128 0.4637 1
0.0134 0.4898 0.8722
0.0227 0.4457 0.6397
0.0075 0.4898 0.5
0.0392 0.5319 1
0.0063 0.3421 0.5
0.0808 0.3072 1
0.0462 0.5323 1
0.0877 0.2716 1
0.0253 0.3273 0.5
0.0833 0.7589 1
0.0197 0.4705 0
0.0669 0.7321 0.5
0.0217 0.2971 0.7576
0.1223 0.681 1
0.0777 0.7591 1
0.0259 0.3283 1
0.0125 0.4898 0.7707
0.0322 0.4898 0.5
0.006 0.3388 0.5
0.03 0.6384 1
0.0862 0.7591 1
0.0115 0.7321 1
0.0217 0.4032 0.5
0.0264 0.8273 0.5
0.1015 0.6722 1
0.0576 0.5439 1
0.0078 0.7077 0.5
0.0088 0.3639 1
0.0917 0.2635 0.5
0.0459 0.561 1
0.0609 0.7248 0.5
0.0065 0.2905 0.5
0.0136 0.3028 0.4672
0.1171 0.6093 0.5
0.0064 0.4994 1
0.0078 0.3555 0.4588
0.0129 0.4898 0.5
0.0158 0.2605 0.2952
0.0057 0.3223 0.5
0.1558 0.7061 1
0.0158 0.2605 0.298
0.0287 0.378 1
0.0188 0.8161 0.5
0.0135 0.3179 0.5
0.0164 0.4219 0
0.0126 0.4898 0.5
0.0062 0.3073 1
0.0343 0.4828 0.5
0.0943 0.2922 1
0.0194 0.462 1
0.022 0.4725 0.8537
0.0808 0.3072 1
0.0253 0.2581 0.5881
0.0134 0.5237 0.5
0.0178 0.2997 0.2856
0.0199 0.4573 0.5
0.0735 0.758 1
0.0135 0.4622 0.5
0.0094 0.4715 0.5975
0.0287 0.378 1
0.1253 0.7058 1
0.0128 0.2617 0.5049
0.0196 0.3684 0
0.0947 0.5867 0.5
0.0877 0.7589 1
0.0194 0.2929 0.5
0.058 0.4771 1
0.0777 0.5815 1
0.1136 0.7059 1
0.0195 0.4582 1
0.1256 0.7061 1
0.0843 0.6597 0.5
0.0202 0.3963 0.5
0.0596 0.7587 1
0.0735 0.7587 1
0.0063 0.3423 0.5
0.014 0.471 0.5
0.0212 0.7359 0.7176
0.1015 0.6722 1
0.0197 0.4405 0.7944
0.1097 0.7253 1
0.0827 0.7143 1
0.0395 0.6047 0.5
0.0722 0.7585 1
0.0133 0.4391 0.5
0.0149 0.3052 0.5385
0.0257 0.5941 1
0.0127 0.5278 0.5
0.0188 0.8161 0.5
0.0743 0.7587 1
0.0067 0.2529 0.5
0.0255 0.3151 0.5
0.013 0.3688 0.3688
0.0101 0.5253 0.5
0.1023 0.5802 0.5
0.0127 0.3622 1
0.0149 0.48 0.5
0.0158 0.2843 0.2952
0.0657 0.5913 1
0.0848 0.3389 0.5
0.0131 0.4898 0.5
0.0329 0.6481 1
0.013 0.4898 0.5
0.0112 0.5265 0.5
0.0066 0.4898 0.5
0.0545 0.758 1
0.1253 0.7058 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv1987 (Mycobacterium tuberculosis), Possible chitinase
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