Detailed view for Rv2394

Basic information

TDR Targets ID: 980522
Mycobacterium tuberculosis, Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase)
Source Database / ID:  Tuberculist 

pI: 5.963 | Length (AA): 643 | MW (Da): 66527 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
58 640 2nlz (A) 3 538 25.00 0 1 1.10169 -0.18
74 642 4y23 (A) 37 579 33.00 0 1 1.19391 -0.12
446 633 2dg5 (B) 391 571 39.00 0 0.78 0.543979 0.87
446 634 2dg5 (B) 391 572 36.00 0.021 0.81 0.506435 0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127021)

Species Accession Gene Product
Arabidopsis thaliana AT4G29210   gamma-glutamyl transpeptidase 4
Arabidopsis thaliana AT4G39650   gamma-glutamyl transpeptidase 2
Arabidopsis thaliana AT4G39640   gamma-glutamyl transpeptidase 1
Brugia malayi Bm1_25455   Gamma-glutamyltranspeptidase family protein
Candida albicans CaO19.6053   likely gamma-glutamyltransferase similar to S. cerevisiae ECM38
Candida albicans CaO19.3640   partial identity with CaP19.6053 N terminus
Candida albicans CaO19.13474   likely gamma-glutamyltransferase similar to S. cerevisiae ECM38
Candida albicans CaO19.11122   partial identity with CaP19.6053 N terminus
Caenorhabditis elegans CELE_C53D5.5   Protein C53D5.5
Caenorhabditis elegans CELE_T03D8.6   Protein T03D8.6, isoform A
Caenorhabditis elegans CELE_H14N18.4   Protein H14N18.4, isoform B
Drosophila melanogaster Dmel_CG1492   CG1492 gene product from transcript CG1492-RA
Drosophila melanogaster Dmel_CG4829   CG4829 gene product from transcript CG4829-RB
Drosophila melanogaster Dmel_CG6461   gamma-glutamyl transpeptidase
Drosophila melanogaster Dmel_CG17636   CG17636 gene product from transcript CG17636-RA
Escherichia coli b3447   gamma-glutamyltranspeptidase
Echinococcus granulosus EgrG_000761500   gamma glutamyltransferase 1
Echinococcus granulosus EgrG_000806300   gamma glutamyltranspeptidase 1
Echinococcus multilocularis EmuJ_000761500   gamma glutamyltransferase 1
Echinococcus multilocularis EmuJ_000806300  
Homo sapiens ENSG00000133475   gamma-glutamyltransferase 2
Homo sapiens ENSG00000131067   gamma-glutamyltransferase 7
Homo sapiens ENSG00000100031   gamma-glutamyltransferase 1
Homo sapiens 102724197   gamma-glutamyltranspeptidase 2-like
Loa Loa (eye worm) LOAG_11860   hypothetical protein
Loa Loa (eye worm) LOAG_10776   gamma-glutamyl transpeptidase
Loa Loa (eye worm) LOAG_13287   hypothetical protein
Loa Loa (eye worm) LOAG_14542   hypothetical protein
Mus musculus ENSMUSG00000027603   gamma-glutamyltransferase 7
Mus musculus ENSMUSG00000006345   gamma-glutamyltransferase 1
Mycobacterium tuberculosis Rv2394   Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase)
Oryza sativa 4336033   Os04g0457500
Onchocerca volvulus OVOC7270  
Onchocerca volvulus OVOC12230  
Saccharomyces cerevisiae YLR299W   gamma-glutamyltransferase
Schistosoma japonicum Sjp_0004210   ko:K00681 gamma-glutamyltranspeptidase [EC2.3.2.2], putative
Schistosoma japonicum Sjp_0055950   Gamma-glutamyltransferase 4 precursor, putative
Schistosoma mansoni Smp_089100   gamma-glutamyltransferase-like protein 3 (T03 family)
Schmidtea mediterranea mk4.011949.00  
Schmidtea mediterranea mk4.014052.01  
Schmidtea mediterranea mk4.003357.00  
Schmidtea mediterranea mk4.010466.01  
Schmidtea mediterranea mk4.026161.00  
Schmidtea mediterranea mk4.011949.03  
Schmidtea mediterranea mk4.003357.02  
Schmidtea mediterranea mk4.021207.01  
Schmidtea mediterranea mk4.024426.01  
Schmidtea mediterranea mk4.000904.07   Gamma-glutamyltransferase 7
Schmidtea mediterranea mk4.005976.02  
Schmidtea mediterranea mk4.010259.02  
Schmidtea mediterranea mk4.021207.02  

Essentiality

Rv2394 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3447 Escherichia coli non-essential goodall
CELE_C53D5.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens gamma-glutamyltransferase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0146 0.531 0.72
0.0144 0.6671 1
0.0146 0.531 0.72
0.0161 0.5019 0.5
0.0146 0.531 0.72
0.0144 0.6671 1
0.0146 0.531 0.72

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv2394 (Mycobacterium tuberculosis), Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase)
Title for this comment
Comment