Detailed view for Rv2394

Basic information

TDR Targets ID: 6135
Mycobacterium tuberculosis, PROBABLE GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR GGTB (GAMMA-GLUTAMYLTRANSFERASE) (GLUTAMYL TRANSPEPTIDASE)

Source Database / ID: Tuberculist / Rv2394 

pI: 5.9662 | Length (AA): 644 | MW (Da): 66527 | Number of Paralogs: 0

EC number(s): 2.3.2.2 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: Y | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003840   gamma-glutamyltransferase activity  
Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 31
Cumulative epitope score: 34.6
Normalized epitope score: 5.4
Percentile: 79.3 (this protein belongs to the top 20.7% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10533
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_974636   GGT4 (GAMMA-GLUTAMYL TRANSPEPTIDASE 4); gamma-glutamyltrans... |   OrthoMCL
Arabidopsis thaliana NP_195675   GGT2 (GAMMA-GLUTAMYL TRANSPEPTIDASE 2); gamma-glutamyltrans... |   OrthoMCL
Arabidopsis thaliana NP_194650   GGT4 (GAMMA-GLUTAMYL TRANSPEPTIDASE 4); gamma-glutamyltrans... |   OrthoMCL
Arabidopsis thaliana NP_195674   GGT1 (GAMMA-GLUTAMYL TRANSPEPTIDASE 1); gamma-glutamyltrans... |   OrthoMCL
Arabidopsis thaliana NP_974717   GGT1 (GAMMA-GLUTAMYL TRANSPEPTIDASE 1); gamma-glutamyltrans... |   OrthoMCL
Brugia malayi Bm1_25455   Gamma-glutamyltranspeptidase family protein... |   OrthoMCL
Caenorhabditis elegans C53D5.5   CE23612 WBGene00016906 gamma-glutamyltranspeptidase status:P... |   OrthoMCL
Caenorhabditis elegans T03D8.6   CE37271 WBGene00011393 Gamma-glutamyltranspeptidase status:P... |   OrthoMCL
Cryptosporidium neoformas XP_569793   protein-glutamine gamma-glutamyltransferase ... |   OrthoMCL
Cryptosporidium neoformas XP_570280   Gamma-glutamyltranspeptidase 1 precursor ... |   OrthoMCL
Drosophila melanogaster FBpp0074393   |   OrthoMCL
Drosophila melanogaster FBpp0111834   |   OrthoMCL
Drosophila melanogaster FBpp0074110   |   OrthoMCL
Drosophila melanogaster FBpp0073423   |   OrthoMCL
Escherichia coli K12 NP_417904.1   gamma-glutamyltranspeptidase periplasmic precursor [Escheric... |   OrthoMCL
Homo sapiens ENSP00000338964   |   OrthoMCL
Homo sapiens ENSP00000248923   |   OrthoMCL
Homo sapiens ENSP00000384349   |   OrthoMCL
Mus musculus ENSMUSP00000029131   |   OrthoMCL
Mus musculus ENSMUSP00000006508   |   OrthoMCL
Mycobacterium tuberculosis Rv2394 (this record).   PROBABLE GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR GGTB (GAMMA-... |   OrthoMCL
Oryza sativa NP_001052974   Os04g0457500 ... |   OrthoMCL
Saccharomyces cerevisiae YLR299W   ECM38 SGDID:S000004290, Chr XII from 726071-728053, Verified... |   OrthoMCL
Schistosoma mansoni Smp_089100   gamma-glutamyltransferase-like protein 3 (T03 family)... |   OrthoMCL

Essentiality Rv2394 has essentiality data
Gene/Ortholog: mtu2435 (OG4_10533); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco3326 (OG4_10533); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco3326 (OG4_10533); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3326 (OG4_10533); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3326 (OG4_10533); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      Rattus norvegicus Gamma-glutamyltranspeptidase 1 Show papers show compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    41 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

    Log in to add comments, or register.