Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.024 | 1 | 1 |
Echinococcus multilocularis | gamma glutamyltransferase 1 | 0.024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 1 | 1 |
Onchocerca volvulus | 0.024 | 1 | 0.5 | |
Loa Loa (eye worm) | gamma-glutamyl transpeptidase | 0.024 | 1 | 1 |
Onchocerca volvulus | 0.024 | 1 | 0.5 | |
Echinococcus granulosus | gamma glutamyltransferase 1 | 0.024 | 1 | 1 |
Schistosoma mansoni | gamma-glutamyltransferase-like protein 3 (T03 family) | 0.024 | 1 | 1 |
Echinococcus granulosus | gamma glutamyltranspeptidase 1 | 0.024 | 1 | 1 |
Mycobacterium tuberculosis | Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase) | 0.0161 | 0.5019 | 0.5 |
Echinococcus multilocularis | 0.024 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 uM | Inhibition of bovine acetylcholinesterase using acetylcholine iodide as substrate incubated for 20 mins prior to substrate addition measured after 3 mins by Ellman's method | ChEMBL. | 23199476 |
Inhibition (binding) | = 15 % | Inhibition of equine butyrylcholinesterase using butyrylthiocholine as substrate at 10 uM incubated for 20 mins prior to substrate addition measured after 3 mins by Ellman's method | ChEMBL. | 23199476 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.