Detailed view for Rv3914

Basic information

TDR Targets ID: 9998
Mycobacterium tuberculosis, Thioredoxin TrxC (TRX) (MPT46)
Source Database / ID:  Tuberculist 

pI: 4.815 | Length (AA): 116 | MW (Da): 12544 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00085   Thioredoxin

Gene Ontology

Mouse over links to read term descriptions.
GO:0015035   protein disulfide oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0045454   cell redox homeostasis  
GO:0006662   glycerol ether metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 112 5vo7 (A) 2 110 82.00 0 1 1.91746 -0.65
9 112 4knd (A) 6 108 42.00 0 1 1.62125 -2.19
21 98 2vim (A) 13 91 44.00 0 1 1.29421 -1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2A87:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2I1U:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2L4Q:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2L59:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3NOF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3O6T:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Dormant phase. murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_126613)

Species Accession Gene Product
Arabidopsis thaliana AT5G39950   thioredoxin H2
Arabidopsis thaliana AT1G19730   thioredoxin H4
Arabidopsis thaliana AT1G69880   thioredoxin H8
Arabidopsis thaliana AT1G45145   thioredoxin H5
Arabidopsis thaliana AT3G51030   thioredoxin H1
Arabidopsis thaliana AT4G03520   thioredoxin M2
Arabidopsis thaliana AT1G03680   thioredoxin M1
Arabidopsis thaliana AT1G43560   thioredoxin Y2
Arabidopsis thaliana AT1G76760   thioredoxin Y1
Arabidopsis thaliana AT5G42980   thioredoxin H3
Arabidopsis thaliana AT3G15360   thioredoxin M4
Arabidopsis thaliana AT3G08710   thioredoxin H9
Babesia bovis BBOV_II003650   thioredoxin, putative
Babesia bovis BBOV_III011040   thioredoxin domain containing protein
Brugia malayi Bm1_27930   thioredoxin
Candida albicans CaO19.7611   potential thioredoxin similar to S. cerevisiae TRX1 (YLR043C)
Caenorhabditis elegans CELE_B0024.9   Protein TRX-2, isoform B
Caenorhabditis elegans CELE_B0228.5   Protein TRX-1, isoform A
Caenorhabditis elegans CELE_Y55F3AR.2   Protein Y55F3AR.2
Caenorhabditis elegans CELE_Y44E3A.3   Protein TRX-4
Cryptosporidium hominis Chro.40188   thioredoxin; Trx1p
Cryptosporidium parvum cgd4_1650   possible thioredoxin H-type of possible fungal or plant origin, small protein
Chlamydia trachomatis CT_539   thioredoxin
Dictyostelium discoideum DDB_G0284939   thioredoxin domain-containing protein
Drosophila melanogaster Dmel_CG3315   Thioredoxin T
Drosophila melanogaster Dmel_CG8993   CG8993 gene product from transcript CG8993-RA
Drosophila melanogaster Dmel_CG13473   CG13473 gene product from transcript CG13473-RA
Drosophila melanogaster Dmel_CG31884   thioredoxin-2
Drosophila melanogaster Dmel_CG4193   deadhead
Drosophila melanogaster Dmel_CG8517   CG8517 gene product from transcript CG8517-RA
Escherichia coli b2582   thioredoxin 2
Escherichia coli b3781   thioredoxin 1
Echinococcus granulosus EgrG_001132900   Thioredoxin fold
Echinococcus granulosus EgrG_000666800   thioredoxin 1
Echinococcus granulosus EgrG_001061600   thioredoxin 2
Echinococcus granulosus EgrG_000666700   thioredoxin
Echinococcus granulosus EgrG_000360300   thioredoxin mitochondrial
Entamoeba histolytica EHI_042900   thioredoxin, putative
Entamoeba histolytica EHI_053840   thioredoxin, putative
Entamoeba histolytica EHI_004490   thioredoxin, putative
Echinococcus multilocularis EmuJ_000666700   thioredoxin
Echinococcus multilocularis EmuJ_000666800   thioredoxin 1
Echinococcus multilocularis EmuJ_000360300   thioredoxin, mitochondrial
Echinococcus multilocularis EmuJ_001061600   thioredoxin 2
Homo sapiens ENSG00000136810   thioredoxin
Homo sapiens ENSG00000100348   thioredoxin 2
Leishmania braziliensis LbrM.01.0300   thioredoxin, putative
Leishmania donovani LdBPK_010270.1   thioredoxin, putative
Leishmania infantum LinJ.01.0270   thioredoxin, putative
Leishmania major LmjF.01.0270   thioredoxin, putative
Leishmania mexicana LmxM.01.0270   thioredoxin, putative
Loa Loa (eye worm) LOAG_05301   hypothetical protein
Mus musculus ENSMUSG00000028367   thioredoxin 1
Mus musculus ENSMUSG00000005354   thioredoxin 2
Mycobacterium tuberculosis Rv3914   Thioredoxin TrxC (TRX) (MPT46)
Mycobacterium tuberculosis Rv1471   Probable thioredoxin TrxB1
Mycobacterium ulcerans MUL_1479   thioredoxin TrxB1
Mycobacterium ulcerans MUL_5067   thioredoxin TrxC
Mycobacterium ulcerans MUL_3116   thioredoxin TrxB1
Neospora caninum NCLIV_000840   Thioredoxin h, related
Neospora caninum NCLIV_036510   hypothetical protein
Oryza sativa 4342593   Os07g0186000
Oryza sativa 4342618   Os07g0190800
Oryza sativa 4339267   Os05g0508500
Oryza sativa 4324458   Os01g0963400
Oryza sativa 4334453   Os03g0800700
Oryza sativa 9270622   Os12g0188700
Oryza sativa 4336484   Os04g0530600
Oryza sativa 4330107   Os02g0639900
Plasmodium berghei PBANKA_0826300   thioredoxin-like protein 2, putative
Plasmodium berghei PBANKA_1320900   thioredoxin 1, putative
Plasmodium falciparum PF3D7_1457200   thioredoxin 1
Plasmodium knowlesi PKNH_1224600   thioredoxin 1, putative
Plasmodium vivax PVX_117605   thioredoxin 1, putative
Plasmodium yoelii PY04185   thioredoxin
Saccharomyces cerevisiae YCR083W   Trx3p
Saccharomyces cerevisiae YLR043C   thioredoxin TRX1
Saccharomyces cerevisiae YGR209C   thioredoxin TRX2
Schistosoma japonicum Sjp_0308060   ko:K03671 thioredoxin 1, putative
Schistosoma japonicum Sjp_0039090   ko:K03671 thioredoxin 1, putative
Schistosoma japonicum Sjp_0069040   ko:K03671 thioredoxin 1, putative
Schistosoma mansoni Smp_008070   thioredoxin
Schistosoma mansoni Smp_054470   thioredoxin 2
Schmidtea mediterranea mk4.001802.00   Thioredoxin-1
Schmidtea mediterranea mk4.000408.10  
Schmidtea mediterranea mk4.000645.04  
Schmidtea mediterranea mk4.000645.02  
Trypanosoma brucei gambiense Tbg972.9.1690   thioredoxin
Trypanosoma brucei Tb927.9.3370   thioredoxin
Trypanosoma congolense TcIL3000_9_970   thioredoxin, putative
Trypanosoma cruzi TcCLB.504797.40   thioredoxin, putative
Trypanosoma cruzi TcCLB.511577.83   thioredoxin, putative
Toxoplasma gondii TGME49_270120   thioredoxin-like protein TLP1
Toxoplasma gondii TGME49_293870   thioredoxin, putative
Treponema pallidum TP0919   thioredoxin (trx)
Theileria parva TP02_0035   thioredoxin, putative
Theileria parva TP04_0217   thioredoxin, putative
Theileria parva TP01_0471   thioredoxin, putative
Trichomonas vaginalis TVAG_428740   thioredoxin, putative
Trichomonas vaginalis TVAG_232840   thioredoxin, putative
Trichomonas vaginalis TVAG_411700   conserved hypothetical protein
Trichomonas vaginalis TVAG_459090   conserved hypothetical protein
Trichomonas vaginalis TVAG_418970   thioredoxin m(mitochondrial)-type, putative
Trichomonas vaginalis TVAG_253800   conserved hypothetical protein
Trichomonas vaginalis TVAG_074180   thioredoxin, putative
Trichomonas vaginalis TVAG_460230   thioredoxin m(mitochondrial)-type, putative
Trichomonas vaginalis TVAG_000290   thioredoxin, putative
Trichomonas vaginalis TVAG_371200   thioredoxin f-type, putative
Trichomonas vaginalis TVAG_389740   thioredoxin, putative
Trichomonas vaginalis TVAG_309720   thioredoxin, putative
Trichomonas vaginalis TVAG_086420   conserved hypothetical protein
Trichomonas vaginalis TVAG_125510   thioredoxin, putative
Trichomonas vaginalis TVAG_416920   thioredoxin m(mitochondrial)-type, putative
Trichomonas vaginalis TVAG_385350   thioredoxin, putative
Trichomonas vaginalis TVAG_415710   thioredoxin, putative
Trichomonas vaginalis TVAG_134260   thioredoxin, putative
Trichomonas vaginalis TVAG_373740   thioredoxin, putative
Trichomonas vaginalis TVAG_145440   thioredoxin, putative
Trichomonas vaginalis TVAG_119500   thioredoxin, putative
Trichomonas vaginalis TVAG_194480   conserved hypothetical protein
Trichomonas vaginalis TVAG_045300   thioredoxin, putative
Trichomonas vaginalis TVAG_081410   thioredoxin f-type, putative
Trichomonas vaginalis TVAG_026340   thioredoxin m(mitochondrial)-type, putative
Trichomonas vaginalis TVAG_085330   thioredoxin, putative
Trichomonas vaginalis TVAG_125500   thioredoxin, putative
Trichomonas vaginalis TVAG_074570   thioredoxin, putative
Trichomonas vaginalis TVAG_086470   thioredoxin f-type, putative
Wolbachia endosymbiont of Brugia malayi Wbm0608   thioredoxin

Essentiality

Rv3914 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.2020 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.2020 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.2020 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.160.2020 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b2582 Escherichia coli non-essential goodall
b3781 Escherichia coli non-essential goodall
PBANKA_0826300 Plasmodium berghei Essential plasmo
PBANKA_1320900 Plasmodium berghei Slow plasmo
TGME49_293870 Toxoplasma gondii Essentiality uncertain sidik
TGME49_270120 Toxoplasma gondii Essentiality uncertain sidik
TGME49_293870 Toxoplasma gondii Probably essential sidik
TGME49_270120 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens thioredoxin 2 Compounds References
Homo sapiens thioredoxin Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.00409799 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3914 (Mycobacterium tuberculosis), Thioredoxin TrxC (TRX) (MPT46)
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