Detailed information for compound 1006056

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 265.308 | Formula: C13H19N3O3
  • H donors: 4 H acceptors: 3 LogP: -0.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1N(Cc2ccc(cc2)C(=N)N)C[C@@H]([C@@H]1O)O
  • InChi: 1S/C13H19N3O3/c14-13(15)9-3-1-8(2-4-9)5-16-6-11(18)12(19)10(16)7-17/h1-4,10-12,17-19H,5-7H2,(H3,14,15)/t10-,11+,12-/m1/s1
  • InChiKey: URZMQRPARYJONA-GRYCIOLGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma vivax IAG-nucleoside hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum inosine-adenosine-guanosine-nucleoside hydrolase, putative Get druggable targets OG5_144830 All targets in OG5_144830
Leishmania major inosine-adenosine-guanosine-nucleoside hydrolase, putative Get druggable targets OG5_144830 All targets in OG5_144830
Trypanosoma brucei gambiense inosine-adenosine-guanosine-nucleosidehydrolase,IAG-nucleoside hydrolase Get druggable targets OG5_144830 All targets in OG5_144830
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative Get druggable targets OG5_144830 All targets in OG5_144830
Leishmania mexicana Get druggable targets OG5_144830 All targets in OG5_144830
Leishmania donovani inosine-adenosine-guanosine-nucleosidehydrolase, putative Get druggable targets OG5_144830 All targets in OG5_144830
Trypanosoma congolense inosine-adenosine-guanosine-nucleosidehydrolase, putative Get druggable targets OG5_144830 All targets in OG5_144830
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative Get druggable targets OG5_144830 All targets in OG5_144830
Trypanosoma brucei inosine-adenosine-guanosine-nucleosidehydrolase Get druggable targets OG5_144830 All targets in OG5_144830
Leishmania braziliensis inosine-adenosine-guanosine-nucleoside hydrolase, putative Get druggable targets OG5_144830 All targets in OG5_144830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein IAG-nucleoside hydrolase   327 aa 296 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0059 0.0737 0.6965
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.4434 0.4854
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1036 0.3268
Leishmania major hypothetical protein, conserved 0.0074 0.1036 0.0991
Trypanosoma brucei inosine-guanine nucleoside hydrolase 0.0059 0.0737 0.069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Mycobacterium ulcerans hypothetical protein 0.0074 0.1036 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1036 0.3976
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0486 0.1463
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0486 0.1828
Mycobacterium leprae Probable lipase LipE 0.0074 0.1036 0.2321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0272 0.076
Plasmodium falciparum glutathione reductase 0.0095 0.1467 1
Brugia malayi beta-lactamase family protein 0.0074 0.1036 0.4011
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1036 0.1127
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.1467 0.5699
Trypanosoma brucei inosine-adenosine-guanosine-nucleosidehydrolase 0.0514 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.3942 0.4315
Mycobacterium tuberculosis Probable nucleoside hydrolase IunH (purine nucleosidase) 0.0059 0.0737 0.0798
Trichomonas vaginalis esterase, putative 0.0074 0.1036 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0025 0.0041 0.0036
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.3245
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0204 0.1092
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1591 0.6217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2403 0.4218
Brugia malayi Thioredoxin reductase 0.0095 0.1467 0.5724
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0272 0.076
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0854
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0204 0.0155
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0204 0.1569
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1036 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1036 1
Brugia malayi Flap endonuclease-1 0.0025 0.0049 0.0091
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.3245
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1036 0.3976
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0204 0.0536
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0204 0.1641
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2403 0.7758
Leishmania major trypanothione reductase 0.0095 0.1467 0.1425
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1036 0.1127
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0737 0.069
Toxoplasma gondii ABC1 family protein 0.0074 0.1036 0.6959
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0204 0.5
Schistosoma mansoni hypothetical protein 0.0101 0.1591 0.2793
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0204 0.0155
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0854
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0025 0.0041 0.0036
Loa Loa (eye worm) glutathione reductase 0.0095 0.1467 0.5699
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0486 0.178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1036 0.1818
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1036 0.4011
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.1467 0.4683
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0854
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Loa Loa (eye worm) hypothetical protein 0.0047 0.0486 0.178
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0025 0.0041 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1036 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.1036 0.1127
Onchocerca volvulus 0.0074 0.1036 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Toxoplasma gondii thioredoxin reductase 0.0095 0.1467 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0059 0.0737 0.6965
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0204 0.0358
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1036 0.1127
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0204 0.0155
Trichomonas vaginalis hypothetical protein 0.0059 0.0737 0.6965
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0204 0.1092
Loa Loa (eye worm) hypothetical protein 0.0101 0.1591 0.6196
Loa Loa (eye worm) hypothetical protein 0.0148 0.2543 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.2403 0.9444
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0204 0.0155
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0514 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2403 0.7758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2403 0.4218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2403 0.4218
Loa Loa (eye worm) hypothetical protein 0.0074 0.1036 0.3976
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2403 0.7758
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.3245
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0049 0.0034
Trypanosoma cruzi inosine-guanine nucleoside hydrolase, putative 0.0059 0.0737 0.069
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0486 0.1463
Loa Loa (eye worm) hypothetical protein 0.0074 0.1036 0.3976
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1036 0.1127
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0216 0.3942 0.8889
Plasmodium falciparum thioredoxin reductase 0.0095 0.1467 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.1036 0.1127
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1036 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0204 0.0155
Schistosoma mansoni hypothetical protein 0.0036 0.0272 0.0478
Schistosoma mansoni hypothetical protein 0.0174 0.3086 0.5416
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0204 0.1092
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.3942 0.4315
Entamoeba histolytica Inosine-uridine preferring nucleoside hydrolase, putative 0.0059 0.0737 1
Echinococcus multilocularis geminin 0.0174 0.3086 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.4434 0.4854
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.1467 0.1425
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0204 0.5
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0049 0.0028
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1036 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0025 0.0041 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1036 0.6959
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0204 0.2252
Loa Loa (eye worm) beta-lactamase 0.0074 0.1036 0.3976
Mycobacterium tuberculosis Conserved protein 0.0074 0.1036 0.1127
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0204 0.0155
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0059 0.0737 0.6965
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0204 0.1569
Echinococcus granulosus flap endonuclease 1 0.0025 0.0049 0.0028
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.1467 0.1599
Mycobacterium ulcerans beta-lactamase 0.0074 0.1036 1
Brugia malayi Disco-interacting protein 2 homolog 0.0025 0.0041 0.0058
Treponema pallidum NADH oxidase 0.0033 0.0204 0.5
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0204 0.0155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.2543 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1036 0.0991
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0204 0.1092
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0041 0.0073
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1036 0.1127
Brugia malayi glutathione reductase 0.0095 0.1467 0.5724
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0486 0.1463
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0204 0.1092
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0204 0.1092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1036 0.3268
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.2543 1
Leishmania major inosine-guanine nucleoside hydrolase, putative 0.0059 0.0737 0.069
Mycobacterium ulcerans lipase LipD 0.0074 0.1036 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2403 0.7758
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0272 0.0478
Brugia malayi beta-lactamase 0.0074 0.1036 0.4011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.3942 0.4315
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.1467 0.4683
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.1467 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0204 0.0706
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.3942 0.4315
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.4434 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0204 0.1641
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1036 0.0991
Loa Loa (eye worm) hypothetical protein 0.0074 0.1036 0.3976
Schistosoma mansoni hypothetical protein 0.0047 0.0486 0.0854
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0025 0.0041 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0486 0.1463
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0025 0.0041 0.0036
Mycobacterium tuberculosis Probable reductase 0.0216 0.3942 0.4315
Echinococcus granulosus GPCR family 2 0.0047 0.0486 0.1463
Plasmodium falciparum thioredoxin reductase 0.0033 0.0204 0.1092
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0514 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0204 0.1641
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0025 0.0041 0.0073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.2403 0.9441
Loa Loa (eye worm) hypothetical protein 0.0074 0.1036 0.3976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.2543 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.9126 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1036 0.3976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0204 0.0155
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.3245
Brugia malayi hypothetical protein 0.0036 0.0272 0.0977
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1036 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.4434 0.4854
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0204 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1036 0.0991
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0025 0.0041 0.0073
Echinococcus multilocularis GPCR, family 2 0.0047 0.0486 0.1463
Trypanosoma brucei trypanothione reductase 0.0095 0.1467 0.1425
Onchocerca volvulus 0.0074 0.1036 0.5
Schistosoma mansoni hypothetical protein 0.0174 0.3086 0.5416
Echinococcus granulosus geminin 0.0174 0.3086 1
Leishmania major nonspecific nucleoside hydrolase 0.0059 0.0737 0.069
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1036 0.1127
Plasmodium vivax glutathione reductase, putative 0.0095 0.1467 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.3942 0.4315
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0204 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0486 0.1828
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0025 0.0041 0.0072
Plasmodium falciparum glutathione reductase 0.0033 0.0204 0.1092
Brugia malayi beta-lactamase family protein 0.0074 0.1036 0.4011
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0204 0.0536
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0204 0.5
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0025 0.0041 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1036 1
Leishmania major hypothetical protein, conserved 0.0059 0.0737 0.069
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0737 0.069
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1036 0.2321
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0059 0.0737 0.6965
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1036 0.1127
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0204 0.0215
Onchocerca volvulus 0.0074 0.1036 0.5
Giardia lamblia Hypothetical protein 0.0059 0.0737 1
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0041 0.0073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1036 0.1818

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 s-galactosidase strain assessed as reduction in parasite growth after 3 days by fluorometrically ChEMBL. 20194690
Activity (functional) Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum Ghana assessed as reduction in parasite growth after 3 days by fluorimetry ChEMBL. 20194690
Activity (functional) Antileishmanial activity against Leishmania infantum MHOM/MA/67/ITMAP263 intracellular amastigotes assessed as reduction in parasite growth after 3 days by fluorometrically ChEMBL. 20194690
IC50 (functional) = 48 uM Antitrypanosomal activity against suramin sensitive Trypanosoma brucei brucei Lister 427 assessed as reduction in parasite growth after 3 days by fluorometrically ChEMBL. 20194690
Ki (binding) = 6.7 uM Inhibition of Trypanosoma vivax IAG-nucleoside hydrolase expressed in Escherichia coli WK6 ChEMBL. 17582660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.