Detailed information for compound 1009350

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.169 | Formula: C16H11Cl2NO3
  • H donors: 0 H acceptors: 2 LogP: 3.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CN1C(=O)C(=O)c2c1c(Cl)ccc2Cl
  • InChi: 1S/C16H11Cl2NO3/c1-22-10-4-2-3-9(7-10)8-19-14-12(18)6-5-11(17)13(14)15(20)16(19)21/h2-7H,8H2,1H3
  • InChiKey: NPOMIKJMXRXVAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, muscarinic 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0079 0.0045 0.0045
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0053 0.0053
Plasmodium falciparum thioredoxin reductase 0.0036 0.0013 0.1971
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.003 0.1032
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0006 0.0913
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0053 0.0053
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0053 0.8478
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.003 0.4311
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0013 0.2325
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0036 0.1958
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0046
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0053 0.0985
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0013 0.1337
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0007 0.0299
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.003 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.002 0.0448
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.018 1
Schistosoma mansoni hypothetical protein 0.0188 0.0124 0.0124
Brugia malayi Probable ClpP-like protease 0.0091 0.0053 0.3432
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0006 0.0913
Plasmodium falciparum glutathione reductase 0.0104 0.0063 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0006 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0006 0.0355
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0053 0.3419
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0039 0.0039
Toxoplasma gondii thioredoxin reductase 0.0104 0.0063 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0011 0.0011
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0017 0.0318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0006 0.0268
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0011 0.0199
Onchocerca volvulus 0.0262 0.0179 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0039 0.0731
Trypanosoma brucei protein kinase, putative 0.0059 0.003 0.4311
Onchocerca volvulus 0.0091 0.0053 0.2749
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.107
Onchocerca volvulus 0.0033 0.0011 0.0302
Entamoeba histolytica hypothetical protein 0.0079 0.0045 0.6532
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0036 0.0036
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0053 0.8478
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.003 0.1652
Plasmodium vivax glutathione reductase, putative 0.0104 0.0063 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0013 0.1337
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0013 0.1337
Echinococcus multilocularis microtubule associated protein 2 0.0754 0.054 0.054
Mycobacterium tuberculosis Probable reductase 0.0237 0.0161 0.8917
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0036 0.0664
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.0156 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0013 0.16
Schistosoma mansoni patched 1 0.0046 0.002 0.002
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0005 0.0863
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.003 0.1934
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0046
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0237 0.0161 0.8917
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.001 0.1422
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0034 0.0034
Mycobacterium ulcerans hypothetical protein 0.0026 0.0006 0.0913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.107
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0005 0.0254
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0013 0.2325
Echinococcus multilocularis geminin 0.0188 0.0124 0.0124
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.004 0.0016 0.0016
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0039 0.5679
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.1337
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0039 0.5938
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0079 0.0045 0.6532
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.002 0.0378
Brugia malayi Pre-SET motif family protein 0.023 0.0156 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0039 0.5813
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0053 0.8357
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.1337
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0011 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.003 0.1032
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.003 0.0557
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0053 0.0989
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0013 0.1337
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.001 0.0245
Loa Loa (eye worm) hypothetical protein 0.0091 0.0053 0.3432
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0011 0.0011
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0034 0.0635
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0006 0.0382
Loa Loa (eye worm) hypothetical protein 0.0028 0.0007 0.0449
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0034 0.2204
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0033 0.0011 0.0692
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.003 0.4135
Echinococcus multilocularis thioredoxin glutathione reductase 0.0104 0.0063 0.0063
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0036 0.5309
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.1006
Schistosoma mansoni hypothetical protein 0.0045 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0057 0.0028 0.1801
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.003 0.003
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0053 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.001 0.0183
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0079 0.0045 0.6532
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.002 0.1311
Brugia malayi glutathione reductase 0.0104 0.0063 0.404
Schistosoma mansoni notum 1.3642 1 1
Brugia malayi hypothetical protein 0.0079 0.0045 0.2866
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.003 0.4311
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0053 0.2753
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0013 0.1971
Brugia malayi CHE-14 protein 0.0046 0.002 0.1311
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0006 0.0015
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0065 0.4209
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.1311
Toxoplasma gondii hypothetical protein 0.0031 0.001 0.0744
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0007 0.1009
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.003 0.1032
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0013 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0045 0.0826
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0013 0.1337
Echinococcus multilocularis expressed conserved protein 0.0101 0.0061 0.0061
Brugia malayi jmjC domain containing protein 0.0065 0.0034 0.2204
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.003 0.0557
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0039 0.2536
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0013 0.1337
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0005 0.0863
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0039 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.107
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0006 0.0355
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0065 0.1213
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0237 0.0161 0.8917
Echinococcus granulosus microtubule associated protein 2 0.0754 0.054 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0036 0.6667
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0006 0.0913
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0011 0.0011
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.003 0.4311
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0053 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0013 0.1337
Schistosoma mansoni hypothetical protein 0.0045 0.0019 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.0099 0.184
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.003 0.4311
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0007 0.0299
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0039 0.5938
Loa Loa (eye worm) hypothetical protein 0.0091 0.0053 0.3419
Trichomonas vaginalis set domain proteins, putative 0.0262 0.0179 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0067 0.0067
Echinococcus multilocularis protein patched 0.0046 0.002 0.002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0013 0.107
Plasmodium vivax SET domain protein, putative 0.0033 0.0011 0.1616
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.018 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.001 0.0891
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0355
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0006 0.0045
Loa Loa (eye worm) glutathione reductase 0.0104 0.0063 0.404
Echinococcus granulosus expressed conserved protein 0.0101 0.0061 0.1124
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0013 0.1337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.107
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0013 0.1971
Echinococcus granulosus geminin 0.0188 0.0124 0.2299
Brugia malayi jmjC domain containing protein 0.0065 0.0034 0.2204
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0006 0.0913
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0039 0.5813
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0355
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0016 0.1006
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0006 0.0043
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0013 0.0013
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0045 0.0019 0.0019
Plasmodium falciparum glutathione reductase 0.0036 0.0013 0.1971
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.003 0.1032
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0005 0.0863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0029 0.1873
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0013 0.0833
Leishmania major trypanothione reductase 0.0104 0.0063 1
Plasmodium vivax thioredoxin reductase, putative 0.0104 0.0063 1
Echinococcus granulosus peptidase Clp S14 family 0.006 0.003 0.0562
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0006 0.0382
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0013 0.2325
Plasmodium falciparum thioredoxin reductase 0.0104 0.0063 1
Echinococcus multilocularis protein dispatched 1 0.0053 0.0025 0.0025
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0013 0.16
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0006 0.0045
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0034 0.0034
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.003 0.4135
Entamoeba histolytica hypothetical protein 0.0079 0.0045 0.6532
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0013 0.1971
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0237 0.0161 0.8917
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0065 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0237 0.0161 0.8888
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0046
Brugia malayi MAP kinase sur-1 0.0059 0.003 0.1934
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0029 0.1873
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0006 0.0043
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0006 0.0015
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0013 0.0683
Mycobacterium tuberculosis Probable dehydrogenase 0.0237 0.0161 0.8917
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0188 0.0124 0.0124
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0005 0.0732
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0013 0.024
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0013 0.1971
Schistosoma mansoni hypothetical protein 0.0045 0.0019 0.0019
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0005 0.0732
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0034 0.0635
Trypanosoma brucei trypanothione reductase 0.0104 0.0063 1
Echinococcus granulosus Protein patched homolog 1 0.0046 0.002 0.0378
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0053 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0006 0.0913
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.003 0.1435
Echinococcus granulosus thioredoxin glutathione reductase 0.0104 0.0063 0.1164
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.003 0.1652
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0053 0.0053
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.001 0.1422
Loa Loa (eye worm) hypothetical protein 0.0058 0.0029 0.1873
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0053 0.8357
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0108 0.0065 0.4209
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0007 0.1009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0006 0.0913
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0034 0.0034
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.018 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0036 0.6667
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0034 0.0034
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.002 0.002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0013 0.2325
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.003 0.4135
Trypanosoma cruzi trypanothione reductase, putative 0.0104 0.0063 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0013 0.107
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.003 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0033 0.0011 0.0692
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0237 0.0161 0.8917
Brugia malayi Thioredoxin reductase 0.0104 0.0063 0.404
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0011 0.0954
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0355
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.003 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0029 0.1873
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0036 0.5309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0013 0.107
Treponema pallidum NADH oxidase 0.0036 0.0013 0.16
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0053 1
Leishmania major hypothetical protein, conserved 0.0028 0.0007 0.0299
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0036 0.6667
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.003 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0006 0.0043
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0053 1
Brugia malayi hypothetical protein 0.0028 0.0007 0.0449
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0039 0.2536
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0006 0.0355
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0011 0.0011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0006 0.0913
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.003 0.4135
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0013 0.107
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0053 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.018 1
Schistosoma mansoni microtubule-associated protein tau 0.0754 0.054 0.054
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0007 0.1009
Loa Loa (eye worm) thioredoxin reductase 0.0104 0.0063 0.404
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0104 0.0063 0.3464

Activities

Activity type Activity value Assay description Source Reference
%max (binding) = 13.26 % Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization at 30 uM relative to acetylcholine ChEMBL. 19438238
%max (binding) = 35.11 % Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization at 30 uM relative to acetylcholine ChEMBL. 19438238
EC50 (binding) = 7.15 uM Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization ChEMBL. 19438238
EC50 (binding) > 30 uM Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization ChEMBL. 19438238

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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