Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.2753 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0063 | 0.1103 | 0.1025 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.3104 | 0.4144 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.3104 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1103 | 0.1961 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.1103 | 0.1395 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.3104 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.0063 | 0.1103 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.3104 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.3104 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.3104 | 0.3044 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.3104 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0076 | 0.1925 | 0.2525 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0063 | 0.1103 | 0.1025 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0076 | 0.1925 | 0.1855 |
Echinococcus granulosus | jumonji domain containing protein | 0.0087 | 0.2634 | 0.257 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.3104 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0076 | 0.1925 | 0.2525 |
Echinococcus granulosus | peregrin | 0.0063 | 0.1103 | 0.1025 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.0296 | 0.0954 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0087 | 0.2634 | 0.257 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3104 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0063 | 0.1103 | 0.1025 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.3104 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0076 | 0.1925 | 0.1855 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0076 | 0.1925 | 0.1855 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.2753 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.3104 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.3104 | 0.3044 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0076 | 0.1925 | 0.3549 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0205 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3104 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.3104 | 0.3044 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3104 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.3104 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0163 | 0.7368 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0129 | 0.5267 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0063 | 0.1103 | 0.1961 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.3896 | 0.7355 |
Brugia malayi | PHD-finger family protein | 0.0063 | 0.1103 | 0.1025 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.3104 | 0.5 |
Echinococcus multilocularis | peregrin | 0.0063 | 0.1103 | 0.1025 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.2753 | 0.8869 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0063 | 0.1103 | 0.1395 |
Giardia lamblia | PHD finger protein 15 | 0.0063 | 0.1103 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.3104 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.3104 | 0.5825 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme | ChEMBL. | 14505670 |
IC50 (binding) | = 16 nM | Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme | ChEMBL. | 14505670 |
IC50 (binding) | = 20 nM | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12014950 |
IC50 (binding) | = 20 nM | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12014950 |
IC50 (binding) | = 0.02 uM | Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II) | ChEMBL. | 12372516 |
IC50 (binding) | = 0.02 uM | Inhibition of inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12781195 |
IC50 (binding) | = 0.02 uM | Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II) | ChEMBL. | 12372516 |
IC50 (binding) | = 0.02 uM | Inhibition of inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12781195 |
IC50 (functional) | = 7 uM | In vitro secondary T-cell (CEM) proliferation assay | ChEMBL. | 12014950 |
IC50 (functional) | = 7 uM | In vitro secondary T-cell (CEM) proliferation assay | ChEMBL. | 12014950 |
IC50 (functional) | > 10 uM | Inhibition of CEM cell proliferation. | ChEMBL. | 12781195 |
IC50 (functional) | > 10 uM | Inhibition of CEM cell proliferation. | ChEMBL. | 12781195 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12014950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.