Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.031 | 0.0255 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0877 | 0.9706 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0092 | 0.0202 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0034 | 0.0183 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0111 | 0.0401 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0096 | 0.0626 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.016 | 0.8081 |
Loa Loa (eye worm) | galectin | 0.0877 | 0.9706 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1225 | 0.4275 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.1225 | 0.1262 |
Echinococcus granulosus | snurportin 1 | 0.0343 | 0.367 | 0.374 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0126 | 0.1225 | 0.1203 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.011 | 0.1036 | 0.7218 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.031 | 0.0255 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0111 | 0.5572 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0096 | 0.0626 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0111 | 0.1055 | 0.1028 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0126 | 0.1225 | 0.1168 |
Brugia malayi | CHE-14 protein | 0.0047 | 0.0329 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0717 | 0.0677 |
Echinococcus multilocularis | protein patched | 0.0047 | 0.0329 | 0.0266 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0173 | 0.0113 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0065 | 0.2713 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0096 | 0.027 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0096 | 0.0099 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.1225 | 0.1262 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.016 | 0.0096 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.0717 | 0.4849 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.1254 | 0.1205 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0329 | 0.0975 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1225 | 0.4275 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0341 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0173 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.016 | 0.0144 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0047 | 0.0329 | 0.0319 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0034 | 0.0183 | 0.0437 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0126 | 0.1225 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0232 | 0.2416 | 0.2489 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.0829 | 0.0854 |
Echinococcus multilocularis | snurportin 1 | 0.0343 | 0.367 | 0.3629 |
Onchocerca volvulus | 0.0033 | 0.0173 | 0.008 | |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0183 | 0.0437 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0628 | 0.4858 |
Brugia malayi | galectin | 0.0877 | 0.9706 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0096 | 0.027 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0768 | 0.848 | 0.847 |
Brugia malayi | galectin | 0.0877 | 0.9706 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0628 | 0.0627 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0096 | 0.0626 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0047 | 0.0329 | 0.0274 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0096 | 0.0626 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0111 | 0.0401 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0341 | 0.0331 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0096 | 0.027 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.1225 | 1 |
Onchocerca volvulus | 0.0493 | 0.537 | 0.5488 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0341 | 0.0279 |
Trichomonas vaginalis | set domain proteins, putative | 0.0264 | 0.2778 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0092 | 0.0234 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0096 | 0.0232 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.016 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1254 | 0.1274 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0111 | 0.0401 |
Loa Loa (eye worm) | runx1 | 0.0062 | 0.0497 | 0.0492 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0183 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0096 | 0.0099 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.016 | 0.0099 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0034 | 0.0183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0877 | 0.9706 | 1 |
Echinococcus granulosus | geminin | 0.0796 | 0.8801 | 0.9061 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.0717 | 0.4849 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0183 | 0.0437 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0143 | 0.1411 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0111 | 0.3923 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0343 | 0.367 | 0.3769 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.011 | 0.1036 | 0.1008 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0126 | 0.1225 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.0628 | 0.0647 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0092 | 0.0234 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0768 | 0.848 | 0.8728 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0628 | 0.4858 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0096 | 0.0626 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.1254 | 0.1205 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0183 | 1 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0126 | 0.1225 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0024 | 0.0065 | 0.2713 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.1225 | 0.1243 |
Brugia malayi | MH2 domain containing protein | 0.0108 | 0.1015 | 0.1046 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.0717 | 0.4849 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0173 | 0.916 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.1225 | 0.1203 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0173 | 0.0113 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0173 | 0.0178 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.016 | 0.0165 |
Brugia malayi | hypothetical protein | 0.0493 | 0.537 | 0.5533 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0096 | 0.0626 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0877 | 0.9706 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0232 | 0.2416 | 0.2473 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0111 | 0.5572 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0081 | 0.0717 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1254 | 0.1274 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0183 | 0.0437 |
Schistosoma mansoni | lozenge | 0.0062 | 0.0497 | 0.0448 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0404 | 0.0342 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0157 | 0.1568 | 0.1559 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0768 | 0.848 | 0.8728 |
Schistosoma mansoni | patched 1 | 0.0047 | 0.0329 | 0.0274 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0173 | 0.0113 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.031 | 0.0255 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0341 | 0.0287 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0628 | 0.0567 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0159 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0449 | 0.0442 |
Onchocerca volvulus | Galectin homolog | 0.0877 | 0.9706 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0183 | 0.0437 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.0278 | 0.0222 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.1225 | 0.1203 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.537 | 0.5524 |
Echinococcus multilocularis | expressed conserved protein | 0.0103 | 0.0961 | 0.0902 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0096 | 0.0232 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.016 | 0.0826 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0143 | 0.1411 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.1225 | 1 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0717 | 0.0739 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.016 | 0.8601 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0111 | 0.0401 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0126 | 0.1225 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0183 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.011 | 0.1036 | 0.1068 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0183 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.367 | 0.374 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0108 | 0.1015 | 0.1027 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0034 | 0.0183 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.002 | 0.01 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0183 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0081 | 0.0717 | 0.0677 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.0717 | 0.4849 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0183 | 0.0437 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0096 | 0.0626 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0341 | 0.0352 |
Echinococcus multilocularis | geminin | 0.0796 | 0.8801 | 0.8793 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0341 | 0.0279 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0126 | 0.1225 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0092 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0877 | 0.9706 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.1225 | 0.8617 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.016 | 0.8601 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.031 | 0.0255 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0173 | 0.0113 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0628 | 0.0584 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0065 | 0.0067 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0047 | 0.0329 | 0.0274 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0877 | 0.9706 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0628 | 0.0584 |
Loa Loa (eye worm) | phosphofructokinase | 0.0126 | 0.1225 | 0.1243 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0034 | 0.0183 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.0278 | 0.0215 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0096 | 0.0232 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0628 | 0.4858 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0081 | 0.0717 | 0.0677 |
Echinococcus granulosus | Galectin carbohydrate recognition domain | 0.0877 | 0.9706 | 1 |
Onchocerca volvulus | 0.0264 | 0.2778 | 0.2791 | |
Echinococcus multilocularis | Galectin, carbohydrate recognition domain | 0.0877 | 0.9706 | 0.9704 |
Loa Loa (eye worm) | hypothetical protein | 0.0877 | 0.9706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0329 | 0.0319 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0073 | 0.0628 | 0.4186 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0341 | 0.0287 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1225 | 0.4275 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0183 | 0.0437 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0111 | 0.0114 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0047 | 0.0329 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.537 | 0.5524 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0096 | 0.0626 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.016 | 0.0826 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0341 | 0.0287 |
Echinococcus multilocularis | Protein lozenge | 0.0062 | 0.0497 | 0.0435 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0092 | 0.01 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0096 | 0.0099 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0173 | 0.0113 |
Schistosoma mansoni | galectin | 0.0877 | 0.9706 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0173 | 0.0109 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0877 | 0.9706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0096 | 0.0078 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0157 | 0.1568 | 0.1513 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0092 | 0.01 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0096 | 0.072 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0341 | 0.0287 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.1225 | 0.8617 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0173 | 0.9388 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1411 | 0.1435 |
Brugia malayi | phosphofructokinase | 0.0126 | 0.1225 | 0.1262 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.1225 | 0.8617 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0096 | 0.0078 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0183 | 1 |
Brugia malayi | hypothetical protein | 0.0129 | 0.1254 | 0.1292 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.0628 | 0.4858 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0111 | 0.5572 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.011 | 0.1036 | 0.0978 |
Echinococcus granulosus | expressed conserved protein | 0.0103 | 0.0961 | 0.093 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0096 | 0.072 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0877 | 0.9706 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0065 | 0.0046 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0173 | 0.0109 |
Schistosoma mansoni | hypothetical protein | 0.0796 | 0.8801 | 0.9061 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0877 | 0.9706 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.1225 | 0.1243 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0034 | 0.0183 | 0.0881 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0096 | 0.0078 |
Loa Loa (eye worm) | galectin | 0.0877 | 0.9706 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0877 | 0.9706 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0796 | 0.8801 | 0.9061 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0111 | 0.0094 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0108 | 0.1015 | 0.1027 |
Onchocerca volvulus | Galectin homolog | 0.0877 | 0.9706 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1225 | 0.4275 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1036 | 0.1049 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.4 ug ml-1 | Cytotoxicity against mouse P388 cells | ChEMBL. | 17618015 |
ED50 (functional) | = 0.5 ug ml-1 | Cytotoxicity against human A549 cells | ChEMBL. | 17618015 |
ED50 (functional) | = 1 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 17618015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.