Detailed information for compound 1016595

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.489 | Formula: C21H31N3O3
  • H donors: 1 H acceptors: 2 LogP: 2.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(=O)NC1CCN(CC1)CCCN1C(=O)COc2c1cccc2)C
  • InChi: 1S/C21H31N3O3/c1-16(2)14-20(25)22-17-8-12-23(13-9-17)10-5-11-24-18-6-3-4-7-19(18)27-15-21(24)26/h3-4,6-7,16-17H,5,8-15H2,1-2H3,(H,22,25)
  • InChiKey: UXVJGEKUGDFIQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1761 0.1975
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.1874 0.7956
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3599 0.3599
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.2632 0.2632
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.1169 0.1311
Loa Loa (eye worm) RNA binding protein 0.0068 0.3599 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0796 0.2649
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0452 0.0452
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.2355 0.6543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.2355 0.2642
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0715 0.1749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.2632 0.2632
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.1874 0.4586
Trichomonas vaginalis ap endonuclease, putative 0.004 0.1874 0.2102
Schistosoma mansoni hypothetical protein 0.0173 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.1874 0.1874
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0657 0.279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.1186 0.133
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.2355 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0715 0.1749
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0022 0.0796 0.01
Leishmania major hypothetical protein, conserved 0.0026 0.102 0.3084
Loa Loa (eye worm) hypothetical protein 0.0035 0.1615 0.4486
Loa Loa (eye worm) hypothetical protein 0.0016 0.0452 0.1257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.023 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0425 0.0476
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.2355 1
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0155 0.8915 1
Echinococcus multilocularis tar DNA binding protein 0.0068 0.3599 0.3599
Mycobacterium tuberculosis Probable aminotransferase 0.0155 0.8915 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0425 0.0476
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0715 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1611 0.1807
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0425 0.1803
Toxoplasma gondii non-specific serine/threonine protein kinase 0.001 0.0063 0.0209
Loa Loa (eye worm) TAR-binding protein 0.0068 0.3599 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.1336 0.1499
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.4086 0.4086
Echinococcus granulosus dna polymerase eta 0.0021 0.0715 0.0715
Giardia lamblia GTOR 0.0048 0.2355 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.2355 0.2355
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0022 0.0796 0.01
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.102 0.2077
Brugia malayi hypothetical protein 0.0026 0.102 0.2497
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3599 0.3599
Schistosoma mansoni hypothetical protein 0.0035 0.1615 0.1615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.1016 0.114
Loa Loa (eye worm) hypothetical protein 0.0021 0.0715 0.1985
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.1874 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0715 0.3034
Trypanosoma brucei unspecified product 0.0014 0.0322 0.1369
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0715 0.3034
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0022 0.0796 0.01
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0452 0.1257
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.343 0.343
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0796 0.01
Mycobacterium ulcerans hypothetical protein 0.0155 0.8915 1
Schistosoma mansoni hypothetical protein 0.0016 0.0452 0.0452
Brugia malayi TAR-binding protein 0.0068 0.3599 0.8809
Schistosoma mansoni hypothetical protein 0.0012 0.0155 0.0155
Echinococcus granulosus tar DNA binding protein 0.0068 0.3599 0.3599
Entamoeba histolytica hypothetical protein 0.0076 0.4086 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.2355 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0425 0.118
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.1874 0.7066
Trichomonas vaginalis ap endonuclease, putative 0.004 0.1874 0.2102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0425 0.0476
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0715 0.3034
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0715 0.0802
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.2616 0.6403
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.2632 0.2632
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.1611 0.5359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.2632 0.2632
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0425 0.1039
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Echinococcus multilocularis cpg binding protein 0.0032 0.1434 0.1434
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.4086 0.4086
Loa Loa (eye worm) hypothetical protein 0.0026 0.102 0.2834
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.1327 0.3687
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.1763 0.7487
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0796 0.0796
Schistosoma mansoni ap endonuclease 0.004 0.1874 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.1399 0.1569
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0796 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.2355 0.2642
Trypanosoma brucei unspecified product 0.0014 0.0322 0.1369
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Echinococcus multilocularis geminin 0.0173 1 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0155 0.8915 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.1874 0.7507
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0155 0.8915 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.2632 0.6442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.2616 0.7269
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.102 0.2077
Schistosoma mansoni DNA polymerase eta 0.0021 0.0715 0.0715
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.1874 0.1874
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.1874 0.4586
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.1763 0.7487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1761 0.1975
Schistosoma mansoni hypothetical protein 0.0016 0.0452 0.0452
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.1874 0.7956
Schistosoma mansoni hypothetical protein 0.0173 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1611 0.1807
Leishmania major DNA polymerase kappa, putative 0.0021 0.0715 0.1502
Echinococcus granulosus Aminotransferase class III 0.0022 0.0796 0.0796
Schistosoma mansoni cpg binding protein 0.0032 0.1434 0.1434
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0715 0.1749
Leishmania major DNA polymerase eta, putative 0.0021 0.0715 0.1502
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0796 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0425 0.0425
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0452 0.1107
Entamoeba histolytica hypothetical protein 0.0076 0.4086 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0452 0.0452
Trypanosoma brucei unspecified product 0.0021 0.0715 0.3034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.1874 0.7956
Schistosoma mansoni cpg binding protein 0.0032 0.1434 0.1434
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.1874 0.5206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1611 0.1807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1761 0.1975
Brugia malayi RNA binding protein 0.0068 0.3599 0.8809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.1019 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1761 0.1975
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.3599 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1611 0.1807
Mycobacterium ulcerans acetylornithine aminotransferase 0.0022 0.0796 0.01
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.2355 0.2355
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.2355 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.102 0.4331
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3599 0.3599
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0425 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0063 0.007
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0796 0.1949
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.102 0.4331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.2355 0.2642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.2632 0.2632
Entamoeba histolytica hypothetical protein 0.0076 0.4086 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.1874 0.1413
Loa Loa (eye worm) hypothetical protein 0.0052 0.2616 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0425 0.0476
Loa Loa (eye worm) histone methyltransferase 0.001 0.0031 0.0087
Echinococcus granulosus GPCR family 2 0.0016 0.0452 0.0452
Brugia malayi CXXC zinc finger family protein 0.0031 0.1327 0.3248
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.1019 0.1143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.2355 0.5764
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1611 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0022 0.0796 0.01
Brugia malayi hypothetical protein 0.0017 0.0464 0.1135
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1615 0.3952
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.2355 1
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0715 0.0715
Schistosoma mansoni hypothetical protein 0.0016 0.0452 0.0452
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0155 0.0155
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.1874 0.1413
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0022 0.0796 0.01
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.3005 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0425 0.0476
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0796 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0715 0.3034
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0022 0.0796 0.01
Schistosoma mansoni hypothetical protein 0.0076 0.4086 0.4086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1611 0.1807
Onchocerca volvulus 0.0031 0.1327 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0024 0.0058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.1169 0.1311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.1761 0.1975
Echinococcus granulosus cpg binding protein 0.0032 0.1434 0.1434
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0824 0.35
Schistosoma mansoni cpg binding protein 0.0031 0.1327 0.1327
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.0796 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.2355 0.2355
Entamoeba histolytica hypothetical protein 0.0076 0.4086 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.102 0.3394
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0452 0.0452
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0155 0.8915 1
Echinococcus multilocularis dna polymerase eta 0.0021 0.0715 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.1611 0.1807
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0031 0.0031
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0715 0.0715
Schistosoma mansoni hypothetical protein 0.0016 0.0452 0.0452
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.1763 0.6934
Mycobacterium ulcerans L-lysine aminotransferase 0.0022 0.0796 0.01
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.1874 1
Brugia malayi hypothetical protein 0.0076 0.4086 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.1874 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.2632 0.2632
Toxoplasma gondii exonuclease III APE 0.004 0.1874 0.6234
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0715 0.0715
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3599 0.3599
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.2632 0.2632
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.1016 0.114
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.1186 0.133
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0796 0.0796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.1019 0.1143
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.102 0.2077
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0174
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0715 0.1985
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0425 0.1803
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0322 0.1369
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.2632 0.7313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.1019 0.1143
Schistosoma mansoni ap endonuclease 0.004 0.1874 0.1874
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3599 0.3599
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0425 0.0425
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0425 0.1803
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0452 0.1107
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.2355 0.5764
Echinococcus granulosus dna polymerase kappa 0.0021 0.0715 0.0715
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0796 0.0796
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.2355 0.5764
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0715 0.3034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.1186 0.133
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0425 0.1803
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.1874 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0322 0.1369
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.102 0.4331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.1016 0.114
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0322 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.193 0.2165
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.4086 0.4086
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.2616 0.6403
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0715 0.3034
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.2355 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0715 0.0802
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0715 0.0715
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.3599 0.8809
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0715 0.1502

Activities

Activity type Activity value Assay description Source Reference
Emax (functional) = 21 % Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux at 10 uM by FLIPR assay relative to acetylcholine ChEMBL. 20684563

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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