Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1024 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0395 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.0241 | 0.0794 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0241 | 0.6096 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.0241 | 0.0794 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.3029 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0241 | 0.0794 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0241 | 0.087 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.1024 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0241 | 0.087 |
Brugia malayi | hypothetical protein | 0.0256 | 0.2765 | 1 |
Onchocerca volvulus | 0.0052 | 0.0395 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0241 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.087 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0241 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.0241 | 0.0794 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0241 | 0.087 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.0241 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0241 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0241 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0256 | 0.2765 | 0.2765 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.3029 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0241 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.087 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0256 | 0.2765 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0249 | 0.2684 | 0.886 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.087 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0241 | 0.0794 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0241 | 0.0241 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0395 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0241 | 0.0794 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.3029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.087 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0241 | 0.2348 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0241 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 0.3029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.087 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1024 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1024 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 0.3029 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0241 | 0.2348 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.3029 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0241 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 0.3029 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 0.3029 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0241 | 0.087 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0241 | 0.087 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0241 | 0.0794 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.087 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0241 | 0.2348 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.3029 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0395 | 0.1427 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0241 | 0.6096 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.1024 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1024 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0241 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2765 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.0241 | 0.0794 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0241 | 0.0794 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.1024 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30 nM | Inhibition of Escherichia coli nickel containing peptide deformylase | ChEMBL. | 21621999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.