Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2491 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.0273 | 0.0471 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.2491 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0794 | 0.0794 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.0273 | 0.0412 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.9718 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0794 | 0.0794 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0794 | 0.1199 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0794 | 0.1199 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.9718 | 0.5 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.0273 | 0.0471 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.0273 | 0.0471 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2491 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0794 | 0.1371 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 0.7808 | 0.5 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.0273 | 0.0412 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.9718 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0794 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0273 | 0.0412 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2491 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.6622 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0185 | 0.579 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 0.9718 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 0.9718 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.9718 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 0.9718 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 0.9718 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0794 | 0.1371 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.6622 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0794 | 0.0794 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0185 | 0.579 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0794 | 0.1199 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0794 | 0.1199 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.9718 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0794 | 0.0794 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2491 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.2491 | 0.5 |
Onchocerca volvulus | 0.0233 | 0.7808 | 1 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0794 | 0.1199 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.0273 | 0.0471 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0794 | 0.0794 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.0273 | 0.0273 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.2491 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 300 nM | Inhibition of Escherichia coli nickel containing peptide deformylase | ChEMBL. | 21621999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.