Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Protein kinase C brain isozyme | 0.00254643 | 0.0168083 | 0.0465797 |
Echinococcus multilocularis | serine threonine protein kinase | 0.00195779 | 0.00142684 | 0.0039541 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0401733 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00926685 | 0.192413 | 0.533222 |
Brugia malayi | protein kinase C II. | 0.00926685 | 0.192413 | 0.192413 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.00679076 | 0.127713 | 0.353922 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.015713 | 0.36085 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.00195779 | 0.00142684 | 0.0039541 |
Echinococcus granulosus | protein kinase c epsilon type | 0.00926685 | 0.192413 | 0.533222 |
Schistosoma mansoni | atypical protein kinase C | 0.00249183 | 0.0153815 | 0.0426256 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.015713 | 0.36085 | 0.36085 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.00249183 | 0.0153815 | 0.0426256 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.00249183 | 0.0153815 | 0.0426256 |
Echinococcus granulosus | ras gtpase | 0.0106502 | 0.228561 | 0.633396 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.00926685 | 0.192413 | 0.192413 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0120772 | 0.265847 | 0.736724 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Echinococcus multilocularis | rho associated protein kinase | 0.0120772 | 0.265847 | 0.736724 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0138098 | 0.31112 | 0.862186 |
Schistosoma mansoni | cell polarity protein | 0.0106502 | 0.228561 | 0.633396 |
Loa Loa (eye worm) | thyroid receptor interactor | 0.00635807 | 0.116407 | 0.116407 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Brugia malayi | GTP-binding protein | 0.0106502 | 0.228561 | 0.228561 |
Brugia malayi | Hr1 repeat family protein | 0.015713 | 0.36085 | 0.36085 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.015713 | 0.36085 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0138098 | 0.31112 | 0.862186 |
Brugia malayi | Protein kinase domain containing protein | 0.0401733 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0120772 | 0.265847 | 0.736724 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00254643 | 0.0168083 | 0.0465797 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.00190318 | 0 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.00254643 | 0.0168083 | 0.0465797 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.00926685 | 0.192413 | 0.533222 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.015713 | 0.36085 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00254643 | 0.0168083 | 0.0465797 |
Brugia malayi | GTP-binding protein, identical | 0.0106502 | 0.228561 | 0.228561 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding protein | 0.0106502 | 0.228561 | 0.228561 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0086236 | 0.175605 | 0.486642 |
Onchocerca volvulus | 0.0120772 | 0.265847 | 1 | |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.00679076 | 0.127713 | 1 |
Toxoplasma gondii | AGC kinase | 0.00190318 | 0 | 0.5 |
Schistosoma mansoni | cell polarity protein | 0.0106502 | 0.228561 | 0.633396 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Echinococcus multilocularis | ras gtpase | 0.0106502 | 0.228561 | 0.633396 |
Trichomonas vaginalis | AGC family protein kinase | 0.00190318 | 0 | 0.5 |
Brugia malayi | Fes/CIP4 homology domain containing protein | 0.00635807 | 0.116407 | 0.116407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.2 nM | Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake | ChEMBL. | 19124242 |
IC50 (functional) | = 2.2 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigerian | ChEMBL. | 19643611 |
IC50 (functional) | = 2.2 nM | Antiplasmodial activity against Plasmodium falciparum | ChEMBL. | 20605450 |
IC50 (functional) | = 2.2 nM | Antimalarial activity against Plasmodium falciparum | ChEMBL. | 20800484 |
IC50 (functional) | = 2.25 nM | Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs | ChEMBL. | 22591034 |
IC50 (functional) | = 2.25 nM | Antiplasmodial activity against Plasmodium falciparum Nigeria infected in human erythrocytes assessed as incorporation of [3H]hypoxanthine after 48 hrs | ChEMBL. | 23289711 |
IC50 (ADMET) | = 347 uM | Cytotoxicity against human Jurkat cells after 24 hrs by [3H]thymidine incorporation assay | ChEMBL. | 23289711 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19124242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.