Detailed information for compound 1020085

Basic information

Technical information
  • TDR Targets ID: 1020085
  • Name: 4-[4-(phenoxy)phenyl]sulfonylbutane-1,2-dithi ol
  • MW: 354.507 | Formula: C16H18O3S3
  • H donors: 0 H acceptors: 2 LogP: 3.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: SCC(CCS(=O)(=O)c1ccc(cc1)Oc1ccccc1)S
  • InChi: 1S/C16H18O3S3/c17-22(18,11-10-15(21)12-20)16-8-6-14(7-9-16)19-13-4-2-1-3-5-13/h1-9,15,20-21H,10-12H2
  • InChiKey: VALKNOMNTXYCBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 14 (membrane-inserted) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Matrixin family protein Get druggable targets OG5_129064 All targets in OG5_129064
Schistosoma japonicum ko:K07996 matrix metalloproteinase-16 (membrane-inserted), putative Get druggable targets OG5_129064 All targets in OG5_129064
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129064 All targets in OG5_129064
Schistosoma japonicum IPR002477,Peptidoglycan-binding domain 1;IPR009070,Peptidoglycan binding-like,domain-containing Get druggable targets OG5_129064 All targets in OG5_129064
Echinococcus granulosus matrix metallopeptidase 7 M10 family Get druggable targets OG5_129064 All targets in OG5_129064
Loa Loa (eye worm) matrixin family protein Get druggable targets OG5_129064 All targets in OG5_129064
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) Get druggable targets OG5_129064 All targets in OG5_129064
Onchocerca volvulus Matrilysin homolog Get druggable targets OG5_129064 All targets in OG5_129064
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) Get druggable targets OG5_129064 All targets in OG5_129064
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.004 0.0515 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0462 0.1379
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0364 0.0354
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0178 0.0069
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0364 0.0439
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0462 0.1379
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0373 0.1423
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0375 0.0375
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0178 0.0528
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0373 0.7803
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0364 0.0354
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.2332 0.3688
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0373 0.1423
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0178 0.0178
Schistosoma mansoni hypothetical protein 0.004 0.0515 0.1532
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.035 0.035
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0462 0.0486
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0163 0.0536
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0364 0.0439
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.2332 0.2813
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.004 0.0086
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0364 0.0439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0163 0.0617
Schistosoma mansoni glucose transport protein 0.0107 0.1922 0.5714
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.035 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0364 0.5715
Onchocerca volvulus 0.0089 0.1546 0.1406
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1922 0.2318
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0364 0.1374
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.035 0.0422
Plasmodium vivax hexose transporter 0.0107 0.1922 0.2053
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0163 0.0617
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0163 0.0536
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0178 0.0214
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1922 0.2318
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0163 0.0327
Schistosoma mansoni hypothetical protein 0.0033 0.0375 0.1116
Loa Loa (eye worm) hypothetical protein 0.0089 0.1546 0.1546
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0364 0.0364
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0373 0.7803
Entamoeba histolytica hypothetical protein 0.0024 0.0178 0.0427
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0373 0.1423
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.035 0.035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0364 0.0439
Brugia malayi hypothetical protein 0.004 0.0515 0.0515
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3305 0.3562
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0515 0.0621
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0462 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.035 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.1922 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.2332 0.2813
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0024 0.0178 0.0178
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Mycobacterium leprae PROBABLE HYDROLASE 0.0109 0.1954 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0163 0.0536
Brugia malayi Matrixin family protein 0.0089 0.1546 0.1546
Onchocerca volvulus Matrilysin homolog 0.0285 0.5641 0.5569
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0163 0.0163
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.01 0.1766 0.5251
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0364 0.0439
Onchocerca volvulus 0.0494 1 1
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0322 0.0388
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Onchocerca volvulus 0.0127 0.2328 0.2201
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0163 0.0536
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0373 0.7803
Leishmania major glucose transporter, lmgt1 0.0033 0.0373 0.0969
Loa Loa (eye worm) hypothetical protein 0.0033 0.0375 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0373 0.1423
Loa Loa (eye worm) matrixin family protein 0.0303 0.6014 0.6014
Onchocerca volvulus Huntingtin homolog 0.012 0.2179 0.205
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0412 0.8292 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.014 0.014
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Loa Loa (eye worm) hypothetical protein 0.0026 0.0224 0.0224
Loa Loa (eye worm) sugar transporter 0.0107 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1922 0.2318
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0163 0.0536
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0178 0.0602
Schistosoma mansoni protein kinase 0.0033 0.0364 0.1083
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0373 0.0969
Brugia malayi Cam kinase protein 1 0.0033 0.0364 0.0364
Entamoeba histolytica hypothetical protein 0.004 0.0515 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0364 0.5715
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0364 0.0354
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0176 0.3363 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.035 0.1339
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0178 0.015
Loa Loa (eye worm) hypothetical protein 0.0032 0.035 0.035
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0163 0.0536
Plasmodium falciparum hexose transporter 0.0107 0.1922 0.2053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0699 0.0699
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0373 0.6871
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1922 0.2318
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.035 0.0422
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0178 0.0528
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.2332 0.6934
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1922 0.2318
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0515 0.1532
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0462 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.1922 0.2985
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0364 0.0354
Schistosoma mansoni glucose transport protein 0.0107 0.1922 0.5714
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0364 0.032
Brugia malayi Cytochrome P450 family protein 0.0022 0.014 0.014
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0109 0.1954 0.1954
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1922 0.2318
Entamoeba histolytica hypothetical protein 0.004 0.0515 1
Plasmodium falciparum protein kinase 6 0.0456 0.9206 1
Schistosoma mansoni hypothetical protein 0.0127 0.2328 0.6921
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3305 0.3562
Loa Loa (eye worm) hypothetical protein 0.0032 0.035 0.035
Schistosoma mansoni lozenge 0.0062 0.0972 0.2889
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0178 0.0602
Trypanosoma brucei glucose transporter 2A 0.0033 0.0373 0.6871
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0364 0.032
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0699 0.0699
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0322 0.0388
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0364 0.032
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0373 0.1423
Schistosoma mansoni hypothetical protein 0.0107 0.1922 0.5714
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3305 0.5352
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0412 0.8292 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0109 0.1954 0.8364
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0364 0.0354
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0364 0.0354
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0364 0.0364
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1922 0.2318
Loa Loa (eye worm) hypothetical protein 0.012 0.2179 0.2179
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0373 0.1423
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.2332 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0373 0.6871
Leishmania major glucose transporter, lmgt3 0.0033 0.0373 0.0969
Echinococcus multilocularis General substrate transporter 0.0092 0.1606 0.1937
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0373 0.1423
Loa Loa (eye worm) hypothetical protein 0.0049 0.0699 0.0699
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0364 0.6561
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0178 0.015
Onchocerca volvulus Huntingtin homolog 0.012 0.2179 0.205
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0373 0.6871
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0102 0.0356
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2332 1
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0462 0.046
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0364 0.0354
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0462 1
Entamoeba histolytica hypothetical protein 0.004 0.0515 1
Brugia malayi Hemopexin family protein 0.0127 0.2328 0.2328
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.035 0.1297
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0102 0.0356
Brugia malayi Matrixin family protein 0.0089 0.1546 0.1546
Trypanosoma cruzi hexose transporter 0.0033 0.0373 0.7803
Onchocerca volvulus Matrix metalloproteinase homolog 0.0198 0.3824 0.3721
Onchocerca volvulus Matrilysin homolog 0.0089 0.1546 0.1406
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0163 0.0536
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.2332 0.6934
Trypanosoma brucei glucose transporter, putative 0.0033 0.0373 0.6871
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0163 0.0163
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0364 0.0364
Brugia malayi hypothetical protein 0.012 0.2179 0.2179
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0364 0.1083
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0178 0.0214
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0364 0.0439
Leishmania major glucose transporter, lmgt2 0.0033 0.0373 0.0969
Loa Loa (eye worm) hypothetical protein 0.012 0.2179 0.2179
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0163 0.0327
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2332 1
Plasmodium falciparum protein kinase 7 0.0304 0.602 0.6524
Mycobacterium ulcerans hydrolase 0.0109 0.1954 0.8349
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0178 0.0408
Brugia malayi Matrixin family protein 0.0303 0.6014 0.6014
Loa Loa (eye worm) hypothetical protein 0.0089 0.1546 0.1546
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.2332 1
Schistosoma mansoni protein kinase 0.0033 0.0364 0.1083
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.035 0.1041
Schistosoma mansoni glucose transport protein 0.0107 0.1922 0.5714
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.1922 0.2318
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0178 0.2979
Brugia malayi Sugar transporter family protein 0.0107 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0494 1 1
Toxoplasma gondii protein kinase, putative 0.0304 0.602 1
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0462 0.046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.2332 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0163 0.0536
Brugia malayi Matrixin family protein 0.0089 0.1546 0.1546
Plasmodium vivax CDK-related protein kinase 6, putative 0.0456 0.9206 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0515 0.0621
Loa Loa (eye worm) matrixin family protein 0.0198 0.3824 0.3824
Loa Loa (eye worm) runx1 0.0062 0.0972 0.0972
Loa Loa (eye worm) hypothetical protein 0.0494 1 1
Loa Loa (eye worm) matrix metalloproteinase 0.0089 0.1546 0.1546
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0178 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0364 0.0354
Trypanosoma brucei glucose transporter 1E 0.0033 0.0373 0.6871
Schistosoma mansoni protein kinase 0.0033 0.0364 0.1083
Loa Loa (eye worm) hypothetical protein 0.0109 0.1954 0.1954
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.004
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0364 0.0439
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0699 0.0699
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0178 0.0342
Brugia malayi Matrixin family protein 0.0089 0.1546 0.1546
Leishmania major protein kinase, putative 0.0033 0.0364 0.0928
Echinococcus multilocularis Protein lozenge 0.0062 0.0972 0.1172
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0364 0.0354
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.035 0.532
Loa Loa (eye worm) hypothetical protein 0.0176 0.3363 0.3363
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0364 0.0439
Loa Loa (eye worm) hypothetical protein 0.0033 0.0364 0.0364
Echinococcus granulosus General substrate transporter 0.0092 0.1606 0.1937

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of MMP7 up to 60 uM ChEMBL. 18790648
Activity (binding) Inhibition of MMP1 up to 60 uM ChEMBL. 18790648
Ki (binding) = 0.046 uM Inhibition of MMP2 ChEMBL. 18790648
Ki (binding) = 0.1 uM Inhibition of MMP9 ChEMBL. 18790648
Ki (binding) = 0.21 uM Inhibition of MMP14 ChEMBL. 18790648
Ki (binding) = 10 uM Inhibition of MMP3 ChEMBL. 18790648

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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