Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.2363 | 0.2363 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0052 | 0.1924 | 0.1924 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1123 | 0.1123 |
Brugia malayi | PHD-finger family protein | 0.0052 | 0.1924 | 0.2065 |
Echinococcus granulosus | enhancer of polycomb | 0.0032 | 0.0911 | 0.0911 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1123 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1123 | 1 |
Echinococcus multilocularis | peregrin | 0.0215 | 1 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.002 | 0.0324 | 0.0347 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.2363 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.1073 | 0.1855 |
Trypanosoma cruzi | transcription elongation factor-like protein, putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | enhancer of polycomb | 0.0032 | 0.0911 | 0.0911 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0.4682 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0052 | 0.1924 | 0.5 |
Brugia malayi | AF-10 protein | 0.0017 | 0.0171 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1123 | 0.1265 |
Brugia malayi | PHD-finger family protein | 0.002 | 0.0324 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0171 | 0.0193 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0017 | 0.0171 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2363 | 0.2662 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0017 | 0.0171 | 0.0724 |
Brugia malayi | Bromodomain containing protein | 0.013 | 0.5783 | 0.6205 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0017 | 0.0171 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1123 | 0.1205 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.2363 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.0052 | 0.1924 | 0.3327 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2363 | 0.5 |
Trypanosoma cruzi | transcription elongation factor s-II, putative | 0.0014 | 0 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0052 | 0.1924 | 0.8144 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0324 | 0.056 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0035 | 0.1073 | 0.1073 |
Plasmodium vivax | hypothetical protein, conserved | 0.0052 | 0.1924 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0035 | 0.1073 | 0.1073 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0052 | 0.1924 | 0.3327 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1123 | 0.1123 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0192 | 0.8877 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0052 | 0.1924 | 0.8144 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0017 | 0.0171 | 0.0193 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | SET domain protein | 0.0017 | 0.0152 | 0.0172 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1123 | 1 |
Onchocerca volvulus | 0.013 | 0.5783 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1123 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.1073 | 0.1151 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1924 | 0.2168 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2363 | 0.5 |
Echinococcus granulosus | E3 ubiquitin protein ligase TRIM33 | 0.0121 | 0.5347 | 0.5347 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2363 | 0.5 |
Schistosoma mansoni | enhancer of polycomb | 0.0032 | 0.0911 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.5783 | 1 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.0017 | 0.0171 | 0.0724 |
Brugia malayi | Bromodomain containing protein | 0.0201 | 0.932 | 1 |
Schistosoma mansoni | transcription intermediary factor 1-related | 0.0121 | 0.5347 | 0.6024 |
Schistosoma mansoni | phd finger protein | 0.0023 | 0.0443 | 0.0499 |
Echinococcus multilocularis | enhancer of polycomb | 0.0032 | 0.0911 | 0.0911 |
Schistosoma mansoni | enhancer of polycomb | 0.0032 | 0.0911 | 0.1026 |
Trypanosoma cruzi | MIZ/SP-RING zinc finger, putative | 0.0014 | 0 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0052 | 0.1924 | 1 |
Echinococcus granulosus | enhancer of polycomb | 0.0032 | 0.0911 | 0.0911 |
Echinococcus multilocularis | E3 ubiquitin protein ligase TRIM33 | 0.0121 | 0.5347 | 0.5347 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1924 | 0.3327 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2363 | 0.2662 |
Schistosoma mansoni | enhancer of polycomb | 0.0032 | 0.0911 | 0.1026 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.2363 | 0.2363 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.4682 | 0.8095 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0052 | 0.1924 | 0.1924 |
Schistosoma mansoni | enhancer of polycomb | 0.0032 | 0.0911 | 0.1026 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1123 | 0.1265 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.2363 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.