Detailed view for LOAG_14224

Basic information

TDR Targets ID: 942342
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 9.6327 | Length (AA): 171 | MW (Da): 20990 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128151)

Species Accession Gene Product
Arabidopsis thaliana AT3G14740   RING/FYVE/PHD zinc finger-containing protein
Babesia bovis BBOV_IV010570   hypothetical protein
Brugia malayi Bm1_20665   Bromodomain containing protein
Candida albicans CaO19.13331   similar to S. cerevisiae NTO1 (YPR031W) Histone Acetyl Transferase complex component
Candida albicans CaO19.5910   similar to S. cerevisiae NTO1 (YPR031W) Histone Acetyl Transferase complex component
Caenorhabditis elegans CELE_F42A9.2   Protein LIN-49
Dictyostelium discoideum DDB_G0283859   BRD group protein
Drosophila melanogaster Dmel_CG1845   CG1845 gene product from transcript CG1845-RB
Echinococcus granulosus EgrG_000955500   peregrin
Echinococcus multilocularis EmuJ_000955500   peregrin
Homo sapiens ENSG00000156983   bromodomain and PHD finger containing, 1
Homo sapiens ENSG00000096070   bromodomain and PHD finger containing, 3
Homo sapiens ENSG00000100425   bromodomain containing 1
Loa Loa (eye worm) LOAG_14224   hypothetical protein
Mus musculus ENSMUSG00000022387   bromodomain containing 1
Mus musculus ENSMUSG00000063952   bromodomain and PHD finger containing, 3
Mus musculus ENSMUSG00000001632   bromodomain and PHD finger containing, 1
Oryza sativa 9271558   Os01g0183700
Saccharomyces cerevisiae YPR031W   Nto1p
Schistosoma japonicum Sjp_0026440   Peregrin, putative
Schistosoma mansoni Smp_097110   bromodomain-containing nuclear protein 1 brd1
Schmidtea mediterranea mk4.013247.01  
Trichomonas vaginalis TVAG_015980   conserved hypothetical protein

Essentiality

LOAG_14224 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F42A9.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens bromodomain and PHD finger containing, 1 Compounds References
Homo sapiens bromodomain and PHD finger containing, 3 Compounds References
Homo sapiens bromodomain containing 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0533 0.4885 1
0.006 0.4633 1
0.0199 0.4633 1
0.0596 0.4965 1
0.0203 0.4566 1
0.055 0.4914 1
0.0317 0.4929 1
0.0251 0.3385 1
0.0597 0.2641 0.8581
0.0597 0.2641 0.8581
0.0478 0.4735 1
0.0411 0.3239 0.5678
0.0055 0.3903 0.588
0.0051 0.3903 0.588
0.0533 0.4885 1
0.0411 0.3239 0.5678
0.005 0.4008 0.588
0.0102 0.4633 1
0.055 0.4914 1
0.0485 0.4752 1
0.0537 0.4934 1
0.0596 0.4965 1
0.0597 0.2641 0.8581
0.011 0.4384 0.5047
0.0253 0.2808 0.9923
0.0051 0.4237 1
0.005 0.3903 0.588
0.0058 0.2624 0.2559
0.0533 0.4885 1
0.0251 0.4633 1
0.005 0.4237 1
0.0054 0.3903 0.588
0.0048 0.4237 1
0.0108 0.4682 0.8095
0.0317 0.4929 1
0.0053 0.3903 0.588
0.0051 0.3903 0.588
0.0054 0.3903 0.588
0.0411 0.3239 0.5678
0.00605283 0.456606 1
0.0485 0.4752 1
0.0054 0.3903 0.588
0.0423 0.4729 1
0.0597 0.2641 0.8581
0.0048 0.4237 1
0.0537 0.4934 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_14224 (Loa Loa (eye worm)), hypothetical protein
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