TDR Targets

Basic information

Technical information

TDR Targets ID: 102637
Name: 4-methyl-2-oxo-N-[2-(1-phenylindol-3-yl)ethyl ]pentanamide
MW: 348.438 | Formula: C22H24N2O2
H donors: 1 H acceptors: 2 LogP: 4.38 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(CC(=O)C(=O)NCCc1cn(c2c1cccc2)c1ccccc1)C
InChi: 1S/C22H24N2O2/c1-16(2)14-21(25)22(26)23-13-12-17-15-24(18-8-4-3-5-9-18)20-11-7-6-10-19(17)20/h3-11,15-16H,12-14H2,1-2H3,(H,23,26)
InChiKey: MPFJVTXECQSEHQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-methyl-2-oxo-N-[2-(1-phenyl-3-indolyl)ethyl]pentanamide
2-keto-4-methyl-N-[2-(1-phenylindol-3-yl)ethyl]valeramide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0364	1
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0014	0.0006
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0317	0.3801	1
Treponema pallidum	hypothetical protein	0.0309	0.3709	1
Echinococcus granulosus	snurportin 1	0.0317	0.3801	1
Echinococcus multilocularis	expressed protein	0.001	0.0014	0.0002
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.016	0.0539
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0309	0.3709	1
Plasmodium falciparum	importin beta, putative	0.003	0.0257	0.0273
Entamoeba histolytica	Ran family GTPase	0.0022	0.016	0.1282
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.001	0.0014	0.0038
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0014	0.0006
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0233	0.2766	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0355	0.1562
Echinococcus multilocularis	protein dispatched 1	0.005	0.0509	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1154	0.3036
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0309	0.3709	1
Brugia malayi	Importin beta-1 subunit	0.003	0.0257	0.089
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0355	0.2994
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0012	0.0032
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.001	0.0014	0.0006
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.1682	0.1672
Schistosoma mansoni	ap endonuclease	0.0038	0.0364	0.0929
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0014	0.0006
Schistosoma mansoni	ap endonuclease	0.0038	0.0364	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0555	0.146
Echinococcus multilocularis	snurportin 1	0.0317	0.3801	0.3794
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0104	0.1173	0.3065
Echinococcus multilocularis	geminin	0.0169	0.1972	0.1962
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0355	0.9729
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0364	1
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.001	0.0014	0.0038
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0192	0.2264	0.8176
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0355	0.9574
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.0433	0.1111
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0309	0.3709	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0146	0.1696	0.1686
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.001	0.0014	0.0008
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0233	0.2766	0.2758
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0014	0.0006
Schistosoma mansoni	hypothetical protein	0.0169	0.1972	0.5172
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Schistosoma mansoni	patched 1	0.0044	0.0433	0.1111
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0014	0.0006
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0014	0.0006
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0364	0.1601
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.016	0.0149
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0044	0.0117
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0309	0.3709	1
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0012	0.0032
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0044	0.0116
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.001	0.0014	0.0038
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0014	0.0002
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0012	0.0032
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0364	0.307
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0044	0.0116
Schistosoma mansoni	hypothetical protein	0.0042	0.0413	0.1059
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0355	0.9729
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0364	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0364	0.0873
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.0433	0.1111
Echinococcus granulosus	expressed protein	0.001	0.0014	0.0006
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.001	0.0014	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0233	0.2766	0.7269
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0364	0.0574
Echinococcus multilocularis	protein patched	0.0044	0.0433	0.0421
Schistosoma mansoni	hypothetical protein	0.0169	0.1972	0.5172
Loa Loa (eye worm)	hypothetical protein	0.001	0.0014	0.0038
Schistosoma mansoni	hypothetical protein	0.0317	0.3801	1
Schistosoma mansoni	hypothetical protein	0.0042	0.0413	0.1059
Echinococcus multilocularis	expressed conserved protein	0.0096	0.1077	0.1067
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0014	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0192	0.2264	0.5956
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.2199	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0102	0.1154	0.4146
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0364	0.1601
Trichomonas vaginalis	ran, putative	0.0022	0.016	0.0669
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0364	1
Echinococcus multilocularis	muscleblind protein	0.0145	0.1682	0.1672
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0014	0.0008
Leishmania major	GTP-binding protein, putative	0.0022	0.016	0.3632
Brugia malayi	RNA, U transporter 1	0.0084	0.0932	0.3342
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0355	0.0906
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0012	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0257	0.0676
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.016	0.3632
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0014	0.0006
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0364	0.0169
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0355	0.1562
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.001	0.0014	0.0008
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.016	0.0392
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0257	0.4746
Brugia malayi	Muscleblind-like protein	0.0145	0.1682	0.6065
Brugia malayi	hypothetical protein	0.001	0.0014	0.0008
Schistosoma mansoni	hypothetical protein	0.0042	0.0413	0.1059
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0355	0.0906
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0012	0.0032
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.0433	0.0421
Schistosoma mansoni	ran	0.0022	0.016	0.0392
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0233	0.2766	0.7278
Onchocerca volvulus		0.001	0.0014	1
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1682	0.4426
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0014	0.0006
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0188	0.0794
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0355	0.085
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0102	0.1154	1
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0014	0.0006
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.001	0.0014	0.0038
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0364	1
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0355	0.0906
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0012	0.0032
Brugia malayi	G-protein alpha subunit	0.001	0.0014	0.0008
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0188	0.0794
Echinococcus multilocularis	Niemann Pick C1 protein	0.0102	0.1154	0.1143
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0364	0.0353
Loa Loa (eye worm)	hypothetical protein	0.001	0.0014	0.0038
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.001	0.0014	0.0002
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.001	0.0014	0.0006
Brugia malayi	Inositol-1	0.0038	0.0355	0.1247
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0014	0.0008
Plasmodium vivax	importin-beta 2, putative	0.003	0.0257	0.0273
Loa Loa (eye worm)	inositol-1	0.0038	0.0355	0.0935
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0257	0.6654
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0309	0.3709	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0233	0.2766	0.7269
Schistosoma mansoni	importin beta-1	0.003	0.0257	0.0647
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.001	0.0014	0.0006
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.0433	0.1139
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.001	0.0014	0.0008
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0014	0.0008
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0188	0.4489
Onchocerca volvulus		0.001	0.0014	1
Echinococcus granulosus	muscleblind protein	0.0145	0.1682	0.4409
Toxoplasma gondii	exonuclease III APE	0.0038	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0433	0.1139
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0355	0.9729
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0433	0.1916
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0364	0.0574
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.016	0.3632
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0012	0.0032
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0233	0.2766	0.2758
Loa Loa (eye worm)	hypothetical protein	0.001	0.0014	0.0038
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0257	0.0245
Echinococcus granulosus	expressed conserved protein	0.0096	0.1077	0.2811
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0014	0.0006
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0014	0.0006
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.016	0.0422
Schistosoma mansoni	ran	0.0022	0.016	0.0392
Loa Loa (eye worm)	hypothetical protein	0.001	0.0014	0.0038
Loa Loa (eye worm)	hypothetical protein	0.001	0.0014	0.0038
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0233	0.2766	0.7269
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0188	0.0794
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0044	0.0116
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0188	0.4489
Echinococcus granulosus	Niemann Pick C1 protein	0.0102	0.1154	0.3014
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0014	0.0002
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.001	0.0014	0.0008
Echinococcus granulosus	Niemann Pick C1 protein	0.0146	0.1696	0.4444
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0014	0.0006
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0355	0.0344
Onchocerca volvulus		0.001	0.0014	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0364	1
Brugia malayi	CHE-14 protein	0.0044	0.0433	0.1528
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0014	0.0006
Entamoeba histolytica	hypothetical protein	0.0024	0.0188	0.1522
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0014	0.0002
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0364	0.0929
Schistosoma mansoni	hypothetical protein	0.0042	0.0413	0.1059
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0012	0.0032
Loa Loa (eye worm)	G protein alpha subunit 3	0.001	0.0014	0.0038
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.001	0.0014	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1682	0.4426
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.016	0.3632
Echinococcus granulosus	importin subunit beta 1	0.003	0.0257	0.0647
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0044	0.0117
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0233	0.2766	0.7269
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0257	0.6654
Echinococcus granulosus	geminin	0.0169	0.1972	0.5172
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0355	0.9729
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0233	0.2766	0.7269
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0355	0.1562
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0032
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0364	0.0958
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0364	0.1278

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.015 ug ml-1	In vitro minimum inhibitory concentration in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622	ChEMBL.	9873483
MIC (functional)	= 0.03 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538	ChEMBL.	9873483
MIC (functional)	= 0.06 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923	ChEMBL.	9873483
MIC (functional)	= 0.06 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213	ChEMBL.	9873483
MIC (functional)	= 0.06 ug ml-1	In vitrIn vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621	ChEMBL.	9873483
MIC (functional)	= 0.125 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503	ChEMBL.	9873483
MIC (functional)	= 1 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663	ChEMBL.	9873483
MIC (functional)	> 64 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538 in addition with 5%serum	ChEMBL.	9873483
MIC (functional)	> 64 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923 in addition with 5%serum	ChEMBL.	9873483
MIC (functional)	> 64 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213 in addition with 5%serum	ChEMBL.	9873483
MIC (functional)	> 64 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621 in addition with 5%serum	ChEMBL.	9873483
MIC (functional)	> 64 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622 in addition with 5%serum	ChEMBL.	9873483
MIC (functional)	> 64 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663 in addition with 5%serum	ChEMBL.	9873483
MIC (functional)	> 64 ug ml-1	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503 in addition with 5%serum	ChEMBL.	9873483

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL63126
PubChem: 9863137

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 102637