Detailed information for compound 1029885

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 160.168 | Formula: C7H12O4
  • H donors: 2 H acceptors: 4 LogP: -0.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)C(=O)[C@H](CO)O
  • InChi: 1S/C7H12O4/c1-2-3-5(9)7(11)6(10)4-8/h6,8,10H,2-4H2,1H3/t6-/m0/s1
  • InChiKey: LHCGIMVMEOPNPW-LURJTMIESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Vibrio harveyi Autoinducer 2-binding periplasmic protein luxP Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0066 0.0262
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0388 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0066 0.0262
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0066 0.0071
Brugia malayi steroid hormone receptor 0.001 0.0066 0.0262
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0066 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0043 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0257 0.6593
Schistosoma mansoni hypothetical protein 0.0419 0.5015 0.5411
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0066 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0797 0.086
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0065 0.0065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0066 0.0071
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0028
Entamoeba histolytica hypothetical protein 0.0077 0.0873 0.0849
Brugia malayi CXXC zinc finger family protein 0.0029 0.0297 0.1174
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0762 0.0822
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0154 0.0609
Schistosoma mansoni hypothetical protein 0.0018 0.0154 0.0166
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0797 0.315
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.044 0.4854
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.1065 0.4207
Schistosoma mansoni cpg binding protein 0.0031 0.0317 0.0343
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.071 0.0766
Loa Loa (eye worm) hypothetical protein 0.0093 0.1065 0.4207
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0615 0.2429
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0007 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0319 0.0319
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.1065 0.1065
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.044 1
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0007 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0007 0.0008
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0257 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0257 0.1922
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0066 0.0262
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.1065 0.1149
Brugia malayi nuclear hormone receptor 0.001 0.0066 0.0262
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0066 0.0071
Brugia malayi Pre-SET motif family protein 0.0214 0.253 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0154 0.0154
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0629 0.7885
Entamoeba histolytica hypothetical protein 0.0077 0.0873 0.0849
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0066 0.0071
Entamoeba histolytica hypothetical protein 0.0077 0.0873 0.0849
Brugia malayi TAR-binding protein 0.0071 0.0797 0.315
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0066 0.0071
Schistosoma mansoni hypothetical protein 0.0038 0.0401 0.0433
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0066 0.0262
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0065 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0762 0.1491
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.044 0.044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0319 0.0344
Schistosoma mansoni hypothetical protein 0.0018 0.0154 0.0166
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0066 0.0229
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0319 0.2915
Loa Loa (eye worm) hypothetical protein 0.0056 0.0615 0.2429
Plasmodium vivax SET domain protein, putative 0.0031 0.0319 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0797 0.086
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0137 0.0148
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.044 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0137 0.0137
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0063 0.025
Schistosoma mansoni nuclear hormone receptor 0.001 0.0066 0.0071
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0322 0.3841 0.4937
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0257 0.1922
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0401 0.1586
Echinococcus granulosus tar DNA binding protein 0.0071 0.0797 0.086
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0066 0.0071
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0762 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0066 0.0071
Schistosoma mansoni hypothetical protein 0.0018 0.0154 0.0166
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.253 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0066 0.0262
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0066 0.0066
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0066 0.0071
Schistosoma mansoni hypothetical protein 0.0077 0.0873 0.0942
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0066 0.0229
Schistosoma mansoni inositol monophosphatase 0.0041 0.044 0.0475
Onchocerca volvulus 0.0031 0.0319 0.1105
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0797 0.315
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.044 0.0558
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0066 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0066 0.0262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0043 0.0046
Echinococcus granulosus microtubule associated protein 2 0.0771 0.9268 1
Brugia malayi Inositol-1 0.0041 0.044 0.1739
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0137 0.0148
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0066 0.0071
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.044 0.0558
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0306 0.3642 0.9445
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0066 0.0262
Schistosoma mansoni microtubule-associated protein tau 0.0771 0.9268 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0066 0.0066
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0257 0.0343
Loa Loa (eye worm) histone methyltransferase 0.001 0.0065 0.0256
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0066 0.0066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0154 0.0609
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0873 0.0942
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0797 0.086
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2887 0.3823
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0137 0.0137
Echinococcus multilocularis cpg binding protein 0.0031 0.0317 0.0317
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0257 0.1922
Echinococcus granulosus FTZ F1 alpha 0.001 0.0066 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0319 0.0344
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0322 0.3841 0.4937
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0137 0.0137
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0066 0.0262
Echinococcus multilocularis microtubule associated protein 2 0.0771 0.9268 0.9268
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0154 0.0166
Brugia malayi isocitrate dehydrogenase 0.0016 0.0137 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.5015 0.5015
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0306 0.3642 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0066 0.0262
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0154 0.0609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0066 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0066 0.0262
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0626 0.7517 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.044 0.4854
Onchocerca volvulus 0.0243 0.2887 1
Onchocerca volvulus 0.0029 0.0297 0.1029
Echinococcus multilocularis GPCR, family 2 0.0018 0.0154 0.0154
Entamoeba histolytica hypothetical protein 0.0077 0.0873 0.0849
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0297 0.1174
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0797 0.086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0066 0.0262
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.044 0.0541
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.044 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0762 0.1782
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0066 0.0262
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0388 0.0365
Loa Loa (eye worm) RNA binding protein 0.0071 0.0797 0.315
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262
Brugia malayi Pre-SET motif family protein 0.0031 0.0319 0.126
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0762 0.1491
Schistosoma mansoni thyroid hormone receptor 0.001 0.0066 0.0071
Brugia malayi hypothetical protein 0.0077 0.0873 0.3452
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0873 0.0873
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0066 0.0262
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0066 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0401 0.1586
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0066 0.0066
Mycobacterium leprae Possible D-ribose-binding protein 0.0322 0.3841 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0066 0.0262
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.044 0.0252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0066 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0066 0.0071
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0066 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0066 0.0066
Brugia malayi RNA binding protein 0.0071 0.0797 0.315
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0066 0.0262
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0257 0.396
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0319 0.0344
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0137 0.0541
Schistosoma mansoni hypothetical protein 0.0018 0.0154 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.044 1
Schistosoma mansoni cpg binding protein 0.0029 0.0297 0.0321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0154 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0066 0.0262
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0043 0.0043
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.044 0.0475
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0615 0.2429
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0007 0.0028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0066 0.0262
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0319 0.0319
Brugia malayi ecdysteroid receptor 0.001 0.0066 0.0262
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0007 0.0028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.044 0.0558
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0797 0.086
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0028
Schistosoma mansoni inositol monophosphatase 0.0041 0.044 0.0475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0066 0.0066
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0066 0.0071
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0797 0.0797
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0298 0.0321
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0615 0.2429
Brugia malayi hypothetical protein 0.0005 0.0007 0.0028
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0137 0.0541
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0066 0.0071
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0762 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0319 0.0344
Echinococcus granulosus dnaJ subfamily B 0.0419 0.5015 0.5411
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0066 0.0262
Brugia malayi hypothetical protein 0.0005 0.0007 0.0028
Echinococcus granulosus GPCR family 2 0.0018 0.0154 0.0166
Schistosoma mansoni thyroid hormone receptor 0.001 0.0066 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0873 0.0942
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0797 0.315
Schistosoma mansoni coup transcription factor 0.001 0.0066 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Loa Loa (eye worm) inositol-1 0.0041 0.044 0.1739
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0319 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0066 0.0262
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.1065 0.1149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0066 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0066 0.0262
Echinococcus granulosus cpg binding protein 0.0031 0.0317 0.0343
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0762 0.0822
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0154 0.0154
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0066 0.0229
Giardia lamblia Fructose-bisphosphate aldolase 0.0626 0.7517 0.5
Onchocerca volvulus 0.001 0.0066 0.0229
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0028
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0257 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0137 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0762 0.1491
Onchocerca volvulus 0.0093 0.1065 0.3687
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0306 0.3642 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262
Brugia malayi nuclear receptor RXR 0.0005 0.0007 0.0028
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0762 0.0822
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0626 0.7517 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0066 0.0262
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0043 0.0046
Schistosoma mansoni cpg binding protein 0.0031 0.0317 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0066 0.0262
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0066 0.0071
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.7517 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0154 0.0166
Treponema pallidum fructose-bisphosphate aldolase 0.0626 0.7517 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0319 0.126
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0262

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Agonist activity at Vibrio harveyi MM30 LuxP assessed as inhibition of autoinducer-2-induced quorum sensing ChEMBL. 19394822
EC50 (functional) = 0.75 uM Agonist activity at Vibrio harveyi BB170 LuxP assessed as inhibition of autoinducer-2-induced quorum sensing after 5 hrs by luminescence assay ChEMBL. 19394822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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