Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0785 | 0.4921 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0109 | 0.0428 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0133 | 0.0584 | 0.0472 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0109 | 0.0428 | 0.0819 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0109 | 0.0428 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0428 | 0.0793 |
Echinococcus granulosus | carboxylesterase 5A | 0.0785 | 0.4921 | 1 |
Brugia malayi | hypothetical protein | 0.0133 | 0.0584 | 0.0348 |
Loa Loa (eye worm) | acetyltransferase | 0.0166 | 0.0805 | 0.1566 |
Schistosoma mansoni | gliotactin | 0.0133 | 0.0584 | 0.1114 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0109 | 0.0428 | 0.0819 |
Echinococcus multilocularis | geminin | 0.0194 | 0.0992 | 0.1819 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0428 | 0.0793 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0118 | 0.2266 |
Echinococcus granulosus | geminin | 0.0194 | 0.0992 | 0.1971 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0109 | 0.0428 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0133 | 0.0584 | 0.1139 |
Mycobacterium ulcerans | monoamine oxidase | 0.0109 | 0.0428 | 0.0314 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0118 | 0.0158 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0133 | 0.0584 | 0.0971 |
Echinococcus granulosus | tumor protein p63 | 0.0348 | 0.2013 | 0.4057 |
Loa Loa (eye worm) | carboxylesterase | 0.0133 | 0.0584 | 0.1114 |
Brugia malayi | Carboxylesterase family protein | 0.0785 | 0.4921 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0109 | 0.0428 | 1 |
Echinococcus multilocularis | neuroligin | 0.0133 | 0.0584 | 0.0971 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0109 | 0.0428 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0133 | 0.0584 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0428 | 0.0793 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0785 | 0.4921 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0166 | 0.0805 | 0.1431 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0166 | 0.0805 | 0.1566 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.0992 | 0.1949 |
Brugia malayi | Carboxylesterase family protein | 0.0785 | 0.4921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0584 | 0.1114 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0133 | 0.0584 | 0.051 |
Plasmodium vivax | hypothetical protein, conserved | 0.0109 | 0.0428 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.0584 | 0.1114 |
Schistosoma mansoni | acetylcholinesterase | 0.0133 | 0.0584 | 0.1114 |
Onchocerca volvulus | 0.0133 | 0.0584 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0584 | 0.1114 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0133 | 0.0584 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0785 | 0.4921 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0109 | 0.0428 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0584 | 0.1114 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0133 | 0.0584 | 0.1139 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0109 | 0.0428 | 0.0339 |
Echinococcus multilocularis | 0.0109 | 0.0428 | 0.0646 | |
Echinococcus granulosus | acetylcholinesterase | 0.0785 | 0.4921 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.0584 | 0.1114 |
Onchocerca volvulus | 0.0109 | 0.0428 | 0.7121 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0109 | 0.0428 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.0584 | 0.0348 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0109 | 0.0428 | 0.0793 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.155 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0133 | 0.0584 | 0.1139 |
Echinococcus multilocularis | acetylcholinesterase | 0.0785 | 0.4921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0428 | 0.0793 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.0584 | 0.0348 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.0584 | 0.0348 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0109 | 0.0428 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0109 | 0.0428 | 0.0314 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0133 | 0.0584 | 0.0971 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0109 | 0.0428 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0166 | 0.0805 | 0.084 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0109 | 0.0428 | 0.0646 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0161 | 0.0774 | 0.1527 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0133 | 0.0584 | 0.051 |
Echinococcus multilocularis | acetylcholinesterase | 0.0785 | 0.4921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0584 | 0.1114 |
Echinococcus multilocularis | tumor protein p63 | 0.0348 | 0.2013 | 0.3945 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0133 | 0.0584 | 0.1114 |
Onchocerca volvulus | 0.0133 | 0.0584 | 1 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0109 | 0.0428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0428 | 0.0793 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0109 | 0.0428 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0109 | 0.0428 | 0.0793 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0109 | 0.0428 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0584 | 0.1114 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0133 | 0.0584 | 0.0971 |
Mycobacterium ulcerans | oxidoreductase | 0.0109 | 0.0428 | 0.0314 |
Onchocerca volvulus | 0.0133 | 0.0584 | 1 | |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.144 | 0.9275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0785 | 0.4921 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0785 | 0.4921 | 1 |
Onchocerca volvulus | 0.0133 | 0.0584 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133 | 0.0584 | 0.1114 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0133 | 0.0584 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0109 | 0.0428 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0109 | 0.0428 | 0.0793 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0133 | 0.0584 | 0.051 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0109 | 0.0428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0584 | 0.1114 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0133 | 0.0584 | 0.1114 |
Loa Loa (eye worm) | carboxylesterase | 0.0785 | 0.4921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0584 | 0.1114 |
Plasmodium vivax | hypothetical protein, conserved | 0.0109 | 0.0428 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0109 | 0.0428 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.0992 | 0.1949 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0428 | 0.0793 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0118 | 0.0186 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0133 | 0.0584 | 0.1139 |
Brugia malayi | Carboxylesterase family protein | 0.0133 | 0.0584 | 0.0348 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0785 | 0.4921 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0109 | 0.0428 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0118 | 0.0158 |
Onchocerca volvulus | 0.0133 | 0.0584 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.