TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.925 | Formula: C20H31ClN2O3
H donors: 2 H acceptors: 2 LogP: 3.17 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: N#CCC(NCC(COc1ccc(cc1)CCOCC1CCC1)O)C.Cl
InChi: 1S/C20H30N2O3.ClH/c1-16(9-11-21)22-13-19(23)15-25-20-7-5-17(6-8-20)10-12-24-14-18-3-2-4-18;/h5-8,16,18-19,22-23H,2-4,9-10,12-15H2,1H3;1H
InChiKey: LHBYKRFRTJEKMG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Beta-1 adrenergic receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cellular tumor antigen P53	0.0026	0.0077	0.0223
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0049	0.0049
Entamoeba histolytica	Ran family GTPase	0.0021	0.0041	0.0706
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0049	0.0059
Schistosoma mansoni	TRABID protein (C64 family)	0.0171	0.116	0.3338
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0098	0.0283
Brugia malayi	YY1-associated factor 2	0.0171	0.116	0.1394
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0041	0.2579
Echinococcus granulosus	ring and YY1 binding protein	0.0171	0.116	0.3338
Echinococcus multilocularis	Niemann Pick C1 protein	0.0134	0.0882	0.0882
Brugia malayi	Importin beta-1 subunit	0.0029	0.0098	0.0118
Trichomonas vaginalis	ran, putative	0.0021	0.0041	0.0118
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0049	0.0059
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0481	0.3475	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0057	0.0494
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0182	0.0524
Schistosoma mansoni	hypothetical protein	0.0039	0.0171	0.0493
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0171	0.116	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0481	0.3475	0.3475
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.1129	0.8318	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0022	0.0049	0.0141
Trypanosoma cruzi	hypothetical protein, conserved	0.0171	0.116	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0049	0.0141
Trichomonas vaginalis	conserved hypothetical protein	0.0481	0.3475	1
Schistosoma mansoni	fusion	0.0171	0.116	0.3338
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0207	0.0207
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0049	0.0059
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0049	0.0049
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0049	0.0049
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0049	0.0049
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0049	0.0141
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0041	0.0118
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0171	0.116	0.3338
Schistosoma mansoni	amine GPCR	0.0022	0.0049	0.0141
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	ran	0.0021	0.0041	0.0118
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0049	0.0141
Schistosoma mansoni	amine GPCR	0.0022	0.0049	0.0141
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0058	0.0312	0.0898
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	hypothetical protein	0.0036	0.0152	0.0437
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.004	0.0182	0.0219
Brugia malayi	neuropeptide F receptor	0.0022	0.0049	0.0059
Chlamydia trachomatis	DNA topoisomerase I	0.0481	0.3475	0.5
Brugia malayi	Dopamine receptor	0.0022	0.0049	0.0059
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0077	0.0093
Echinococcus multilocularis	zinc finger protein Ran binding	0.0171	0.116	0.116
Echinococcus multilocularis	expressed conserved protein	0.0088	0.0539	0.0539
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0049	0.0049
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0049	0.0049
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0171	0.116	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Brugia malayi	G protein-coupled receptor	0.0022	0.0049	0.0059
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0207	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0041	0.0041
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.004	0.0182	0.0219
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0159	0.0458
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0159	0.1373
Echinococcus granulosus	sterol regulatory element binding protein	0.004	0.0182	0.0524
Brugia malayi	NNMT/PNMT/TEMT family protein	0.1129	0.8318	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0207	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0058	0.0312	0.0898
Echinococcus granulosus	Niemann Pick C1 protein	0.0134	0.0882	0.2538
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0049	0.0049
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0171	0.116	0.3338
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0049	0.025	0.03
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0191
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	importin beta-1	0.0029	0.0098	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0049	0.0141
Onchocerca volvulus		0.0171	0.116	0.3243
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0049	0.0141
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0041	0.0118
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0049	0.0141
Brugia malayi	SWIB/MDM2 domain containing protein	0.0481	0.3475	0.4177
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	Serotonin receptor	0.0022	0.0049	0.0059
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0049	0.0141
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	RNA binding protein	0.0171	0.116	0.3338
Echinococcus granulosus	tumor protein p63	0.0179	0.1218	0.3506
Trypanosoma cruzi	hypothetical protein, conserved	0.0171	0.116	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0098	0.0118
Brugia malayi	brahma associated protein 60 kDa	0.0481	0.3475	0.4177
Echinococcus granulosus	expressed conserved protein	0.0088	0.0539	0.1552
Brugia malayi	RE15519p	0.0022	0.0049	0.0059
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0049	0.0049
Entamoeba histolytica	hypothetical protein	0.0023	0.0057	0.0985
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.1129	0.8318	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	hypothetical protein	0.0036	0.0152	0.0182
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0049	0.0141
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0171	0.116	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Trypanosoma brucei	hypothetical protein, conserved	0.0171	0.116	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0481	0.3475	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	SWI:SNF matrix associated	0.0481	0.3475	1
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0057	0.0165
Echinococcus granulosus	hypothetical protein	0.0022	0.0049	0.0141
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0049	0.0141
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0016	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0049	0.0141
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0049	0.0059
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0049	0.0141
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0098	0.0283
Schistosoma mansoni	amine GPCR	0.0022	0.0049	0.0141
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0152	0.0152
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0159	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0049	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0159	0.0458
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Entamoeba histolytica	hypothetical protein	0.0036	0.0152	0.2609
Schistosoma mansoni	zinc finger protein	0.0171	0.116	0.3338
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0207	0.0249
Leishmania major	hypothetical protein, conserved	0.0171	0.116	1
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0049	0.0141
Onchocerca volvulus		0.0481	0.3475	1
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	SWI:SNF matrix associated	0.0481	0.3475	0.3475
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0049	0.0049
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0049	0.0059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0049	0.0141
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0152	0.0437
Schistosoma mansoni	opsin-like receptor	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	larval opioid receptor	0.0022	0.0049	0.0059
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0049	0.0141
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0016	0	0.5
Leishmania major	hypothetical protein, conserved	0.0171	0.116	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0159	0.0458
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0057	0.0165
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0481	0.3475	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0049	0.0141
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0171	0.116	0.1394
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0098	0.0846
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0098	0.0098
Schistosoma mansoni	opsin-like receptor	0.0022	0.0049	0.0141
Onchocerca volvulus		0.0171	0.116	0.3243
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0481	0.3475	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0098	0.0846
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0049	0.0049
Echinococcus granulosus	somatostatin receptor	0.0022	0.0049	0.0141
Plasmodium falciparum	importin beta, putative	0.0029	0.0098	0.0283
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0049	0.0141
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0159	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0049	0.0049
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0171	0.116	0.1394
Echinococcus granulosus	Niemann Pick C1 protein	0.0094	0.0582	0.1674
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	protein dispatched 1	0.0046	0.0225	0.0225
Schistosoma mansoni	ran	0.0021	0.0041	0.0118
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0171	0.116	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0094	0.0582	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0049	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0049	0.0141
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0041	0.0118
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0159	0.0458
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0041	0.0049
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0049	0.0141
Toxoplasma gondii	ran binding protein	0.0171	0.116	0.3338
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0049	0.0059
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0058	0.0312	0.0375
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0058	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	opsin-like receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	tumor protein p63	0.0179	0.1218	0.1218
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0049	0.0049
Echinococcus multilocularis	sterol regulatory element binding protein	0.004	0.0182	0.0182
Echinococcus granulosus	snurportin 1	0.0309	0.2191	0.6305
Onchocerca volvulus		0.0026	0.0077	0.0083
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0049	0.0059
Echinococcus multilocularis	Niemann Pick C1 protein	0.0094	0.0582	0.0582
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0171	0.116	1
Brugia malayi	AKH receptor	0.0022	0.0049	0.0059
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0049	0.0141
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	brahma associated protein	0.0481	0.3475	0.4177
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0057	0.0494
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0171	0.116	0.1394
Echinococcus granulosus	serotonin receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0171	0.116	0.1394
Brugia malayi	neuropeptide F receptor	0.0022	0.0049	0.0059
Echinococcus multilocularis	serotonin receptor	0.0022	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0022	0.0049	0.0141
Schistosoma mansoni	adenoreceptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0022	0.0049	0.0141
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0049	0.0141
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0049	0.0059
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0049	0.0141
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0481	0.3475	1
Schistosoma mansoni	hypothetical protein	0.0481	0.3475	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0041	0.0354
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	patched 1	0.004	0.0182	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0049	0.0141
Brugia malayi	putative neuropeptide receptor	0.0022	0.0049	0.0059
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0054	0.0283	0.034
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0309	0.2191	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0049	0.0141
Trypanosoma cruzi	WLM domain containing protein, putative	0.0171	0.116	1
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0171	0.116	0.3338
Echinococcus granulosus	Zinc finger RanBP2 type	0.0171	0.116	0.3338
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0171	0.116	0.3338
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0481	0.3475	1
Loa Loa (eye worm)	hypothetical protein	0.1129	0.8318	1
Onchocerca volvulus		0.0171	0.116	0.3243
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0049	0.0141
Brugia malayi	Serotonin receptor	0.0022	0.0049	0.0059
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0159	0.0191
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0057	0.0165
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0058	0.0312	1
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0049	0.0049
Leishmania major	hypothetical protein, conserved	0.0171	0.116	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Plasmodium vivax	hypothetical protein, conserved	0.0481	0.3475	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0041	0.0354
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	amine GPCR	0.0022	0.0049	0.0141
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0049	0.0049
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0049	0.0049
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0049	0.0049
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0049	0.0049
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0159	0.1373
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0207	0.0596
Echinococcus multilocularis	snurportin 1	0.0309	0.2191	0.2191
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0049	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	hypothetical protein	0.0039	0.0171	0.0493
Schistosoma mansoni	hypothetical protein	0.0481	0.3475	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0049	0.0141
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0159	0.0458
Echinococcus multilocularis	geminin	0.017	0.1153	0.1153
Schistosoma mansoni	hypothetical protein	0.017	0.1153	0.3318
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Leishmania major	GTP-binding protein, putative	0.0021	0.0041	0.0354
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0171	0.116	1
Leishmania major	hypothetical protein, conserved	0.0171	0.116	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	hypothetical protein	0.0039	0.0171	0.0493
Entamoeba histolytica	hypothetical protein	0.0036	0.0152	0.2609
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0098	0.0283
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0159	0.1373
Brugia malayi	brahma associated protein 60 kDa	0.0481	0.3475	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0582	0.0699
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0049	0.0049
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0094	0.0582	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0049	0.0141
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0171	0.116	0.1394
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0049	0.0049
Brugia malayi	sulfakinin receptor protein	0.0022	0.0049	0.0059
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0159	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0207	0.0207
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0481	0.3475	0.4177
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0058	0.0312	0.2691
Trypanosoma cruzi	hypothetical protein, conserved	0.0171	0.116	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0049	0.0059
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0207	0.0596
Echinococcus granulosus	geminin	0.017	0.1153	0.3318
Schistosoma mansoni	amine GPCR	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0171	0.116	0.1394
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0207	0.0596
Onchocerca volvulus		0.0171	0.116	0.3243
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0049	0.0049
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0095	0.0592	0.1705
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0049	0.0141
Schistosoma mansoni	hypothetical protein	0.017	0.1153	0.3318
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0049	0.0049
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0049	0.0141
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0049	0.0141
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0058	0.0312	1
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0159	0.0458
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0159	0.0458
Echinococcus multilocularis	SWI:SNF matrix associated	0.0481	0.3475	0.3475
Brugia malayi	GnHR receptor homolog	0.0022	0.0049	0.0059
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0481	0.3475	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0049	0.0141
Entamoeba histolytica	hypothetical protein	0.0036	0.0152	0.2609
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0171	0.116	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	ring and YY1 binding protein	0.0171	0.116	0.116
Trypanosoma brucei	hypothetical protein, conserved	0.0171	0.116	1
Echinococcus multilocularis	serotonin receptor	0.0022	0.0049	0.0049
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0049	0.0059
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0159	0.2739
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0049	0.0141
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.0049	0.0059
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	myosin xvIII	0.0022	0.0049	0.0141
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0049	0.0059
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0159	0.0159
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0049	0.0141
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0152	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0049	0.0141
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	hypothetical protein	0.0022	0.0049	0.0141
Brugia malayi	G-protein coupled receptor	0.0022	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0049	0.0141
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0049	0.0141
Chlamydia trachomatis	SWIB complex protein	0.0481	0.3475	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0049	0.0059
Echinococcus granulosus	Protein patched homolog 1	0.004	0.0182	0.0524
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0041	0.0049
Entamoeba histolytica	hypothetical protein	0.0036	0.0152	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0058	0.0312	1
Schistosoma mansoni	brg-1 associated factor	0.0481	0.3475	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0049	0.0141
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0049	0.0049
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0171	0.116	0.3243
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0049	0.0059
Brugia malayi	CHE-14 protein	0.004	0.0182	0.0219
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0049	0.0049
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0049	0.0059
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0049	0.0141
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0481	0.3475	0.3475
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0049	0.0059
Schistosoma mansoni	hypothetical protein	0.0039	0.0171	0.0493
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0049	0.0059
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0049	0.0141
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.0049	0.0059
Echinococcus granulosus	sex peptide receptor	0.0022	0.0049	0.0141
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0207	0.0249
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0049	0.0049
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0159	0.0159
Schistosoma mansoni	hypothetical protein	0.0309	0.2191	0.6305
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0171	0.116	0.116
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0049	0.0141
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0049	0.0141
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0171	0.116	0.116
Loa Loa (eye worm)	hypothetical protein	0.0171	0.116	0.1394
Echinococcus multilocularis	protein patched	0.004	0.0182	0.0182
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0171	0.116	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0041	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	RNA, U transporter 1	0.0082	0.0497	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0049	0.0141
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0049	0.0059
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0159	0.0159
Brugia malayi	G-protein coupled receptor	0.0022	0.0049	0.0059
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0049	0.0049
Echinococcus granulosus	zinc finger protein Ran binding	0.0171	0.116	0.3338
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0059
Brugia malayi	hypothetical protein	0.0022	0.0049	0.0059
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0049	0.0141
Trypanosoma cruzi	WLM domain containing protein, putative	0.0171	0.116	1
Leishmania major	hypothetical protein, conserved	0.0171	0.116	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.116	0.1394
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0049	0.0141
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0041	0.0118

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (functional)	= 6.47	Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria	ChEMBL.	2884312

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL543717

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1033906