Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0053 | 0.0305 | 0.0305 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0047 | 0.016 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0277 | 0.2966 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0084 | 0.0676 | 0.2278 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0135 | 0.1282 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0137 | 0.0217 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.008 | 0.0625 | 0.0625 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0047 | 0.0047 |
Schistosoma mansoni | gabp alpha | 0.0084 | 0.0676 | 0.1065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0277 | 0.2966 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0053 | 0.0305 | 0.0305 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0191 | 0.1952 | 0.1027 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0053 | 0.0305 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0531 | 0.1791 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0233 | 0.2443 | 0.8237 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0486 | 0.0765 |
Schistosoma mansoni | glutamate receptor kainate | 0.0053 | 0.0305 | 0.048 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0191 | 0.1952 | 0.1027 |
Brugia malayi | RNA binding protein | 0.0068 | 0.0486 | 0.1637 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0047 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0047 | 0.0075 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0233 | 0.2443 | 0.8237 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0233 | 0.2443 | 0.385 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0047 | 0.016 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.0486 | 0.1637 |
Chlamydia trachomatis | glutamine binding protein | 0.0135 | 0.1282 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0135 | 0.1282 | 0.5 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0084 | 0.0676 | 0.2278 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0053 | 0.0305 | 0.0305 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.008 | 0.0625 | 0.082 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0053 | 0.0305 | 0.0399 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.0486 | 0.1637 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0047 | 0.0047 |
Echinococcus multilocularis | NMDA receptor | 0.0053 | 0.0305 | 0.0305 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0486 | 0.0765 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0053 | 0.0305 | 0.0399 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.1207 | 0.4068 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0053 | 0.0305 | 0.1027 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0047 | 0.0075 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0277 | 0.2966 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0053 | 0.0305 | 0.048 |
Trypanosoma brucei | RNA helicase, putative | 0.0101 | 0.0875 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.008 | 0.0625 | 0.0625 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0047 | 0.0075 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0233 | 0.2443 | 0.2443 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0135 | 0.1282 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0474 | 0.1599 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0137 | 1 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0084 | 0.0676 | 0.0886 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0053 | 0.0305 | 0.048 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0053 | 0.0305 | 0.0399 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0669 | 0.7628 | 0.7628 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.0486 | 0.1637 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0233 | 0.2443 | 0.385 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0669 | 0.7628 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0277 | 0.2966 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0047 | 0.0075 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0135 | 0.1282 | 0.5 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0053 | 0.0305 | 0.0305 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0875 | 0.1378 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0233 | 0.2443 | 0.3203 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0047 | 0.0062 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0053 | 0.0305 | 0.0399 |
Loa Loa (eye worm) | fli-1 protein | 0.0255 | 0.2704 | 0.9115 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0561 | 0.6346 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0509 | 0.572 | 0.572 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0277 | 0.2966 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0233 | 0.2443 | 0.3203 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0047 | 0.016 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.008 | 0.0625 | 0.0625 |
Echinococcus granulosus | geminin | 0.0349 | 0.3825 | 0.5014 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0053 | 0.0305 | 0.048 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0233 | 0.2443 | 0.2443 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0137 | 0.0463 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.1207 | 0.4068 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0084 | 0.0676 | 0.0676 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0137 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0053 | 0.0305 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0474 | 0.1599 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0053 | 0.0305 | 0.0305 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.008 | 0.0625 | 0.082 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0842 | 0.2839 |
Schistosoma mansoni | glutamate receptor kainate | 0.0053 | 0.0305 | 0.048 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.008 | 0.0625 | 0.082 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0182 | 0.1836 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0135 | 0.1282 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.3825 | 0.6027 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0053 | 0.0305 | 0.048 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0277 | 0.2966 | 1 |
Schistosoma mansoni | ets-related | 0.0255 | 0.2704 | 0.4261 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0474 | 0.0747 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0842 | 0.2839 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0047 | 0.016 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0137 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0277 | 0.2966 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.0486 | 0.0486 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0137 | 0.0137 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0486 | 0.0765 |
Leishmania major | extracellular receptor, putative | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0486 | 0.0765 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0137 | 0.018 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.0486 | 0.0637 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0842 | 0.2839 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.0486 | 0.1637 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0842 | 0.2839 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0137 | 0.0217 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0486 | 0.0765 |
Echinococcus granulosus | glutamate receptor 2 | 0.008 | 0.0625 | 0.082 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0137 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0277 | 0.2966 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.1207 | 0.4068 |
Brugia malayi | Ets-domain containing protein | 0.0084 | 0.0676 | 0.2278 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0482 | 0.54 | 0.7079 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.0486 | 0.1637 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0305 | 0.048 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0233 | 0.2443 | 0.385 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0053 | 0.0305 | 0.1027 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.008 | 0.0625 | 0.0625 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0482 | 0.54 | 0.54 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0047 | 0.0062 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.008 | 0.0625 | 0.082 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0188 | 0.1907 | 0.1907 |
Brugia malayi | Fli-1 protein | 0.0255 | 0.2704 | 0.9115 |
Echinococcus multilocularis | glutamate receptor 2 | 0.008 | 0.0625 | 0.0625 |
Echinococcus multilocularis | geminin | 0.0349 | 0.3825 | 0.3825 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0053 | 0.0305 | 0.0399 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0509 | 0.572 | 0.75 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.3825 | 0.6027 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0053 | 0.0305 | 0.048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.