Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 451 aa | 393 aa | 25.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0002 | 0.5 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0741 | 0.2579 | 1 |
Brugia malayi | hypothetical protein | 0.0088 | 0.0192 | 0.0494 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0192 | 0.0494 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1101 | 0.3898 | 1 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0049 | 0.0052 | 0.0191 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0065 | 0.0111 | 0.042 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1101 | 0.3898 | 1 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.277 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.1083 | 0.2779 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0049 | 0.0052 | 0.0191 |
Schistosoma mansoni | eyes absent homolog | 0.0088 | 0.0192 | 0.0738 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0741 | 0.2579 | 0.6617 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0723 | 0.2513 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.1101 | 0.3898 | 1 |
Echinococcus multilocularis | potassium large conductance calcium activated | 0.0065 | 0.0111 | 0.042 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0332 | 0.1083 | 0.4195 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0002 | 0.5 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0724 | 0.252 | 0.6465 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0259 | 0.0818 | 0.2099 |
Echinococcus granulosus | potassium large conductance calcium activated | 0.0065 | 0.0111 | 0.042 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0332 | 0.1083 | 0.2779 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0002 | 0.0006 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0259 | 0.0818 | 0.2099 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.1101 | 0.3898 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1101 | 0.3898 | 1 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0049 | 0.0052 | 0.0132 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0741 | 0.2579 | 1 |
Mycobacterium ulcerans | malate synthase G | 0.277 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0761 | 0.2655 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0761 | 0.2655 | 0.1027 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0332 | 0.1083 | 0.4195 |
Brugia malayi | MH2 domain containing protein | 0.0259 | 0.0818 | 0.2099 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0192 | 0.0494 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1101 | 0.3898 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.1083 | 0.2779 |
Echinococcus granulosus | calcium activated potassium channel | 0.0065 | 0.0111 | 0.042 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0049 | 0.0052 | 0.0191 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1101 | 0.3898 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0002 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1101 | 0.3898 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0741 | 0.2579 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0065 | 0.0111 | 0.042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 25 nM | Affinity of the compound for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-gabazine antagonist from rat brain preparations. | ChEMBL. | 1331456 |
IC50 (binding) | = 160 nM | Binding affinity in vivo for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-GABA agonist from rat brain preparations after iv injection. | ChEMBL. | 1331456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.