Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.102 | 0.0939 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.102 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.021 | 0.025 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.102 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0527 | 0.8728 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.102 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.016 | 0.2184 | 0.9525 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.092 | 0.3408 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.102 | 0.389 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0157 | 0.2132 | 0.2952 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.0032 | 0.0045 |
Brugia malayi | GMP reductase | 0.0039 | 0.0032 | 0.0045 |
Trichomonas vaginalis | set domain proteins, putative | 0.0598 | 1 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.102 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.102 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0157 | 0.2132 | 0.2984 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0051 | 0.0235 | 0.0016 |
Plasmodium vivax | SET domain protein, putative | 0.0166 | 0.2293 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.102 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.2293 | 0.3178 |
Brugia malayi | PAS domain containing protein | 0.0051 | 0.0235 | 0.0329 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.102 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.092 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0438 | 0.7146 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0039 | 0.0032 | 0.0032 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0166 | 0.2293 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.102 | 0.1389 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.102 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0045 | 0.0133 | 0.1301 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.2368 | 0.3283 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0166 | 0.2293 | 0.2435 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.0222 | 0.0967 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0166 | 0.2293 | 0.2435 |
Onchocerca volvulus | 0.0527 | 0.8728 | 0.8728 | |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.5555 | 0.7764 |
Brugia malayi | glutathione reductase | 0.0049 | 0.021 | 0.0294 |
Brugia malayi | SET domain containing protein | 0.0367 | 0.5874 | 0.822 |
Brugia malayi | Pre-SET motif family protein | 0.0438 | 0.7146 | 1 |
Schistosoma mansoni | single-minded | 0.0051 | 0.0235 | 0.0016 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.0032 | 0.0045 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.102 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.021 | 0.025 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.102 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0166 | 0.2293 | 0.3209 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.102 | 0.4449 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0166 | 0.2293 | 0.2435 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.005 | 0.0217 | 0.0092 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.0217 | 0.0954 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.102 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0166 | 0.2293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.5765 | 0.8059 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.102 | 0.4449 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0166 | 0.2293 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.021 | 0.0294 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.092 | 0.9016 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.102 | 1 |
Brugia malayi | hypothetical protein | 0.017 | 0.2368 | 0.3313 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.102 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.0222 | 0.0967 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0166 | 0.2293 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.102 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.