TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.776 | Formula: C15H19ClN2O3
H donors: 1 H acceptors: 3 LogP: 2.27 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H](C(=O)CN1C(=O)c2c(C1=O)cccc2)CC(C)C.Cl
InChi: 1S/C15H18N2O3.ClH/c1-9(2)7-12(16)13(18)8-17-14(19)10-5-3-4-6-11(10)15(17)20;/h3-6,9,12H,7-8,16H2,1-2H3;1H/t12-;/m0./s1
InChiKey: DVXDLCVNBOMBDF-YDALLXLXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	elastase, neutrophil expressed	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	transmembrane protease serine 3	elastase, neutrophil expressed	267 aa	236 aa	27.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0035	0.0057	0.0517
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0093	0.0104
Echinococcus granulosus	potassium channel subfamily K 8	0.0047	0.0093	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Schistosoma mansoni	hypothetical protein	0.0047	0.0093	0.0103
Echinococcus multilocularis	histone deacetylase 6	0.0328	0.0933	0.1043
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0047	0.0093	0.0991
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0093	0.0104
Trypanosoma cruzi	histone deacetylase, putative	0.0138	0.0365	0.1481
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0093	0.0104
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0035	0.0057	0.0199
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0025	0.0026	0.0183
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0034	0.0025
Entamoeba histolytica	hypothetical protein	0.0028	0.0034	0.0025
Plasmodium vivax	histone deacetylase, putative	0.0138	0.0365	0.3845
Echinococcus granulosus	snurportin 1	0.0365	0.1043	0.1166
Echinococcus granulosus	small conductance calcium activated potassium	0.0971	0.2854	0.3189
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0146	0.0389	0.038
Trichomonas vaginalis	histone deacetylase, putative	0.028	0.0789	0.078
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.1641	0.486	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.028	0.0789	0.3249
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0106	0.0371
Plasmodium falciparum	histone deacetylase 1	0.028	0.0789	0.8434
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	intermediate filament protein	0.0058	0.0123	0.1321
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0026	0.0282
Schistosoma mansoni	ran	0.0025	0.0026	0.0029
Plasmodium vivax	histone deacetylase 1, putative	0.028	0.0789	0.8434
Trichomonas vaginalis	histone deacetylase, putative	0.028	0.0789	0.078
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0047	0.0093	0.0991
Brugia malayi	Histone deacetylase family protein	0.0328	0.0933	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0135	0.0354	0.0396
Echinococcus granulosus	histone deacetylase 6	0.0328	0.0933	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0047	0.0093	0.0991
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0093	0.0997
Echinococcus multilocularis	lamin	0.0058	0.0123	0.0138
Echinococcus granulosus	histone deacetylase	0.0328	0.0933	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0971	0.2854	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0044	0.0049
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0112	0.0285	0.3057
Loa Loa (eye worm)	histone deacetylase 3	0.028	0.0789	0.2764
Schistosoma mansoni	calcium-activated potassium channel	0.0047	0.0093	0.0103
Echinococcus multilocularis	potassium channel subfamily K 8	0.0047	0.0093	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0047	0.0093	0.0991
Brugia malayi	jmjC domain containing protein	0.0035	0.0057	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0057	0.012	0.0421
Echinococcus multilocularis	cpg binding protein	0.0033	0.0049	0.0055
Echinococcus multilocularis	twik family of potassium channels	0.0047	0.0093	0.0103
Schistosoma mansoni	intermediate filament proteins	0.0058	0.0123	0.0138
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0047	0.0093	0.0991
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0106	0.1134
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0146	0.0389	0.1582
Onchocerca volvulus		0.0047	0.0093	0.1516
Onchocerca volvulus		0.0047	0.0093	0.1516
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.028	0.0789	0.078
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	jmjC domain containing protein	0.0035	0.0057	0.0612
Trypanosoma brucei	histone deacetylase 3	0.0328	0.0933	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.3359	1	1
Echinococcus multilocularis	jumonji domain containing 1A	0.0035	0.0057	0.0064
Echinococcus granulosus	dnaJ subfamily B	0.0442	0.1274	0.1424
Brugia malayi	hypothetical protein	0.0047	0.0093	0.0991
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0138	0.0363	0.0729
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0047	0.0093	0.0324
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0057	0.02
Toxoplasma gondii	histone deacetylase HDAC5	0.0138	0.0365	0.3845
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0146	0.0389	0.0435
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0047	0.0093	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus multilocularis	phd:f box containing protein	0.0035	0.0057	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus multilocularis	calcium activated potassium channel variant	0.0047	0.0093	0.0103
Onchocerca volvulus		0.0047	0.0093	0.1516
Trypanosoma cruzi	ion transport protein, putative	0.0822	0.2408	1
Toxoplasma gondii	histone deacetylase HDAC4	0.0138	0.0365	0.3845
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0047	0.0093	0.0899
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0146	0.0389	0.0435
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0047	0.0093	0.0991
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0146	0.0389	0.1582
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0037	0.0062	0.007
Loa Loa (eye worm)	TWK-7 protein	0.0047	0.0093	0.0324
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0047	0.0093	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0138	0.0363	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0031	0.0109
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0133	0.0349	0.039
Brugia malayi	hypothetical protein	0.0047	0.0093	0.0991
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.0026	0.0092
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0138	0.0363	0.0406
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0093	0.0104
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0138	0.0363	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0009	0.0101
Echinococcus multilocularis	histone deacetylase 1	0.028	0.0789	0.0881
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Onchocerca volvulus		0.0058	0.0123	0.2477
Brugia malayi	Histone deacetylase family protein	0.0328	0.0933	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0009	0.0033
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0047	0.0093	0.0083
Schistosoma mansoni	cpg binding protein	0.0033	0.0049	0.0055
Echinococcus multilocularis	histone deacetylase 7	0.0328	0.0933	0.1043
Leishmania major	GTP-binding protein, putative	0.0025	0.0026	0.007
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0026	0.007
Trypanosoma cruzi	histone deacetylase 1, putative	0.028	0.0789	0.3249
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0034	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Leishmania major	hypothetical protein, conserved	0.0035	0.0057	0.0199
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0025	0.0026	0.0183
Trypanosoma cruzi	histone deacetylase, putative	0.0328	0.0933	0.3852
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0146	0.0389	0.0435
Leishmania major	histone deacetylase, putative	0.028	0.0789	0.3249
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0112	0.0285	0.0319
Brugia malayi	histone deacetylase 1 (HD1)	0.028	0.0789	0.845
Loa Loa (eye worm)	histone deacetylase 11	0.0138	0.0365	0.1278
Trypanosoma cruzi	histone deacetylase, putative	0.0328	0.0933	0.3852
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Toxoplasma gondii	histone deacetylase HDAC1	0.0328	0.0933	1
Schistosoma mansoni	phosphatidylserine receptor	0.0035	0.0057	0.0064
Echinococcus granulosus	lysine specific demethylase 6a	0.0035	0.0057	0.0064
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Echinococcus multilocularis	geminin	0.0393	0.1126	0.1258
Echinococcus multilocularis	potassium channel subfamily K 8	0.0047	0.0093	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0031	0.0109
Schistosoma mansoni	hypothetical protein	0.0365	0.1043	0.1166
Schistosoma mansoni	histone deacetylase 4 5	0.0328	0.0933	0.1043
Trypanosoma cruzi	hypothetical protein, conserved	0.0047	0.0093	0.0346
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0047	0.0093	0.0991
Entamoeba histolytica	Ran family GTPase	0.0025	0.0026	0.0017
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0047	0.0093	0.0324
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0047	0.0093	0.0083
Treponema pallidum	fructose-bisphosphate aldolase	0.3359	1	1
Schistosoma mansoni	hypothetical protein	0.0393	0.1126	0.1258
Echinococcus granulosus	phd:f box containing protein	0.0035	0.0057	0.0064
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Plasmodium falciparum	importin beta, putative	0.0034	0.0053	0.0475
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0025	0.0026	0.0183
Leishmania major	histone deacetylase, putative	0.0328	0.0933	0.3852
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0047	0.0093	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Loa Loa (eye worm)	hypothetical protein	0.028	0.0789	0.2764
Echinococcus multilocularis	lysine specific demethylase 6a	0.0035	0.0057	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Loa Loa (eye worm)	uncoordinated protein 58	0.0047	0.0093	0.0324
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0053	0.0475
Brugia malayi	Histone deacetylase 1	0.028	0.0789	0.845
Plasmodium vivax	potassium channel, putative	0.0047	0.0093	0.0899
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus granulosus	histone deacetylase 8	0.0138	0.0365	0.0408
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0138	0.0363	0.0406
Loa Loa (eye worm)	hypothetical protein	0.019	0.052	0.1821
Echinococcus granulosus	histone deacetylase 6	0.0328	0.0933	0.1043
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0047	0.0093	0.0083
Echinococcus granulosus	intermediate filament protein	0.0058	0.0123	0.0138
Schistosoma mansoni	jumonji domain containing protein	0.0035	0.0057	0.0064
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0043	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0057	0.02
Schistosoma mansoni	calcium-activated potassium channel	0.0971	0.2854	0.3189
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0146	0.0389	0.1363
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0138	0.0365	1
Trypanosoma brucei	histone deacetylase 4	0.0328	0.0933	1
Echinococcus multilocularis	histone deacetylase 6	0.0328	0.0933	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0034	0.0025
Leishmania major	calcium/potassium channel (CAKC), putative	0.0047	0.0093	0.0346
Echinococcus granulosus	lysine specific demethylase 5A	0.0135	0.0354	0.0396
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.1641	0.486	1
Leishmania major	hypothetical protein, conserved	0.0047	0.0093	0.0346
Trypanosoma brucei	histone deacetylase, putative	0.0328	0.0933	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.052	0.1821
Plasmodium vivax	JmjC domain containing protein	0.0035	0.0057	0.0517
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.3359	1	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0053	0.0475
Loa Loa (eye worm)	TWK-28 protein	0.0047	0.0093	0.0324
Echinococcus multilocularis	histone deacetylase 3	0.028	0.0789	0.0881
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0047	0.0093	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus granulosus	microtubule associated protein 2	0.3008	0.8949	1
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0053	0.0475
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0106	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Mycobacterium ulcerans	transmembrane cation transporter	0.0047	0.0093	0.0171
Onchocerca volvulus		0.0058	0.0123	0.2477
Trypanosoma cruzi	hypothetical protein, conserved	0.0047	0.0093	0.0346
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0047	0.0093	0.0103
Echinococcus multilocularis	twik family of potassium channels	0.0047	0.0093	0.0103
Toxoplasma gondii	histone deacetylase HDAC3	0.028	0.0789	0.8434
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0047	0.0093	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Toxoplasma gondii	histone deacetylase HDAC2	0.028	0.0789	0.8434
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Echinococcus multilocularis	histone deacetylase	0.0328	0.0933	0.1043
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0044	0.0154
Plasmodium falciparum	potassium channel	0.0047	0.0093	0.0899
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0133	0.0349	0.039
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0047	0.0093	0.0346
Schistosoma mansoni	cpg binding protein	0.0033	0.0049	0.0055
Echinococcus multilocularis	histone deacetylase 6	0.0328	0.0933	0.1043
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0035	0.0057	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus granulosus	lamin dm0	0.0058	0.0123	0.0138
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0034	0.0025
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0047	0.0093	0.0083
Echinococcus granulosus	histone deacetylase 3	0.028	0.0789	0.0881
Brugia malayi	jmjC domain containing protein	0.0133	0.0349	0.374
Echinococcus granulosus	histone deacetylase 7	0.0328	0.0933	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0034	0.012
Schistosoma mansoni	histone deacetylase 4 5	0.0328	0.0933	0.1043
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0112	0.0285	0.0319
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0047	0.0093	0.0346
Schistosoma mansoni	hypothetical protein	0.0442	0.1274	0.1424
Echinococcus multilocularis	lysine specific demethylase 5A	0.0133	0.0349	0.039
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0035	0.0057	0.0517
Onchocerca volvulus		0.0047	0.0093	0.1516
Plasmodium vivax	histone deacetylase, putative	0.0328	0.0933	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0009	0.0011
Echinococcus granulosus	twik family of potassium channels	0.0047	0.0093	0.0103
Echinococcus granulosus	potassium channel subfamily K 8	0.0047	0.0093	0.0103
Leishmania major	ion transport protein-like protein	0.0822	0.2408	1
Loa Loa (eye worm)	hypothetical protein	0.0487	0.1406	0.4928
Leishmania major	potassium channel subunit-like protein	0.0047	0.0093	0.0346
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0047	0.0093	0.0991
Entamoeba histolytica	histone deacetylase, putative	0.028	0.0789	0.078
Brugia malayi	jmjC domain containing protein	0.0135	0.0354	0.3796
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0112	0.0285	0.0319
Plasmodium falciparum	histone deacetylase 2	0.0328	0.0933	1
Schistosoma mansoni	histone deacetylase	0.028	0.0789	0.0881
Echinococcus granulosus	transcription factor Dp 1	0.0085	0.0205	0.0229
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.1641	0.486	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0047	0.0093	0.0991
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0025	0.0026	0.0017
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0057	0.02
Schistosoma mansoni	protein phosphatase 2C	0.0035	0.0057	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0053	0.0187
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0047	0.0093	0.0899
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0093	0.0104
Echinococcus multilocularis	transcription factor Dp 1	0.0085	0.0205	0.0229
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0057	0.02
Echinococcus multilocularis	snurportin 1	0.0365	0.1043	0.1166
Echinococcus multilocularis	small conductance calcium activated potassium	0.0971	0.2854	0.3189
Brugia malayi	histone deacetylase 3 (HD3)	0.028	0.0789	0.845
Echinococcus multilocularis	potassium channel subfamily K	0.0047	0.0093	0.0103
Brugia malayi	Importin beta-1 subunit	0.0034	0.0053	0.0571
Leishmania major	histone deacetylase, putative	0.0328	0.0933	0.3852
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0047	0.0093	0.0991
Trichomonas vaginalis	ran, putative	0.0025	0.0026	0.0017
Trypanosoma cruzi	ion transport protein, putative	0.0822	0.2408	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0135	0.0354	0.0396
Loa Loa (eye worm)	intermediate filament protein	0.0058	0.0123	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0146	0.0389	0.4167
Schistosoma mansoni	hypothetical protein	0.0971	0.2854	0.3189
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0146	0.0389	0.4108
Echinococcus granulosus	potassium channel subfamily K	0.0047	0.0093	0.0103
Plasmodium falciparum	histone deacetylase, putative	0.0328	0.0933	1
Schistosoma mansoni	hypothetical protein	0.0393	0.1126	0.1258
Schistosoma mansoni	calcium-activated potassium channel	0.0047	0.0093	0.0103
Loa Loa (eye worm)	voltage-gated potassium channel	0.0108	0.0275	0.0964
Echinococcus granulosus	cpg binding protein	0.0033	0.0049	0.0055
Schistosoma mansoni	aldehyde dehydrogenase	0.0138	0.0363	0.0406
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0035	0.0057	0.0199
Loa Loa (eye worm)	histone deacetylase	0.0328	0.0933	0.3271
Brugia malayi	jmjC domain containing protein	0.0035	0.0057	0.0612
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0138	0.0363	0.0729
Schistosoma mansoni	importin beta-1	0.0034	0.0053	0.006
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Trypanosoma brucei	histone deacetylase 2	0.0138	0.0365	0.3845
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0034	0.0038
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0053	0.0475
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Toxoplasma gondii	ion channel protein	0.0047	0.0093	0.0899
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0148	0.0165
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0057	0.0609
Brugia malayi	histone deacetylase 11	0.0138	0.0365	0.3907
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Loa Loa (eye worm)	histone deacetylase 1	0.028	0.0789	0.2764
Echinococcus multilocularis	JmjC domain containing protein 4	0.0035	0.0057	0.0064
Echinococcus multilocularis	dnaJ subfamily B	0.0442	0.1274	0.1424
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0044	0.047
Schistosoma mansoni	lamin	0.0058	0.0123	0.0138
Brugia malayi	Intermediate filament tail domain containing protein	0.0058	0.0123	0.1321
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0026	0.007
Echinococcus granulosus	calcium activated potassium channel variant	0.0047	0.0093	0.0103
Brugia malayi	RNA, U transporter 1	0.0097	0.0242	0.2592
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0053	0.006
Schistosoma mansoni	ran	0.0025	0.0026	0.0029
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.0026	0.0029
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0057	0.02
Echinococcus multilocularis	lamin dm0	0.0058	0.0123	0.0138
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.0026	0.0029
Echinococcus granulosus	histone deacetylase 6	0.0328	0.0933	0.1043
Trypanosoma brucei	histone deacetylase 1	0.028	0.0789	0.8434
Trypanosoma cruzi	histone deacetylase, putative	0.0328	0.0933	0.3852
Schistosoma mansoni	jumonji domain containing protein	0.0133	0.0349	0.039
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0047	0.0093	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus granulosus	jumonji domain containing 1A	0.0035	0.0057	0.0064
Echinococcus multilocularis	microtubule associated protein 2	0.3008	0.8949	1
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Loa Loa (eye worm)	jmjC domain-containing protein	0.0135	0.0354	0.1242
Echinococcus granulosus	lamin	0.0058	0.0123	0.0138
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0058	0.0123	0.0432
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0047	0.0093	0.0083
Schistosoma mansoni	ap endonuclease	0.002	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0437	0.1257	0.4405
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0034	0.0102
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0106	0.0371
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0035	0.0057	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0365	0.1278
Onchocerca volvulus		0.0047	0.0093	0.1516
Onchocerca volvulus		0.0047	0.0093	0.1516
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.3359	1	1
Brugia malayi	jmjC domain containing protein	0.0035	0.0057	0.0612
Echinococcus granulosus	histone deacetylase 1	0.028	0.0789	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0037	0.0062	0.007
Toxoplasma gondii	aldehyde dehydrogenase	0.0138	0.0363	0.3826
Schistosoma mansoni	aldehyde dehydrogenase	0.0138	0.0363	0.0406
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0035	0.0057	0.0517
Plasmodium falciparum	potassium channel	0.0047	0.0093	0.0899
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0009	0.0011
Schistosoma mansoni	histone deacetylase	0.028	0.0789	0.0881
Schistosoma mansoni	lamin	0.0058	0.0123	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0057	0.02
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0047	0.0093	0.0991
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0093	0.0104
Echinococcus granulosus	JmjC domain containing protein 4	0.0035	0.0057	0.0064
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0047	0.0093	0.0991
Onchocerca volvulus		0.0047	0.0093	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0123	0.0432
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0047	0.0093	0.0324
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0146	0.0389	0.1582
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0093	0.0326
Echinococcus granulosus	twik family of potassium channels	0.0047	0.0093	0.0103
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0127	0.1273
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0093	0.0104
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0047	0.0093	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0047	0.0093	0.0991
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0034	0.0102
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.0093	0.0103
Giardia lamblia	Hypothetical protein	0.0047	0.0093	0.0083
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0047	0.0093	0.0991
Trichomonas vaginalis	histone deacetylase, putative	0.028	0.0789	0.078
Plasmodium vivax	histone deacetylase 2, putative	0.0328	0.0933	1
Trichomonas vaginalis	histone deacetylase, putative	0.028	0.0789	0.078
Toxoplasma gondii	ion channel protein	0.0047	0.0093	0.0899
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0025	0.0026	0.0183
Schistosoma mansoni	hypothetical protein	0.0035	0.0057	0.0064
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0009	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0043	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Schistosoma mansoni	histone deacetylase hda2	0.0138	0.0365	0.0408
Loa Loa (eye worm)	histone deacetylase 7A	0.0328	0.0933	0.3271
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0047	0.0093	0.0103
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0047	0.0093	0.0346
Schistosoma mansoni	phd/f-box containing protein	0.0035	0.0057	0.0064
Trypanosoma cruzi	histone deacetylase, putative	0.0138	0.0365	0.1481
Echinococcus multilocularis	musashi	0.0058	0.0123	0.0138
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.028	0.0789	0.078
Mycobacterium ulcerans	ion transport protein	0.0129	0.0336	0.0673
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0047	0.0093	0.0991
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0138	0.0363	0.1474
Onchocerca volvulus		0.0047	0.0093	0.1516
Schistosoma mansoni	ap endonuclease	0.002	0.0009	0.0011
Schistosoma mansoni	histone deacetylase hda2	0.0328	0.0933	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0057	0.0199
Schistosoma mansoni	microtubule-associated protein tau	0.3008	0.8949	1
Echinococcus granulosus	geminin	0.0393	0.1126	0.1258
Leishmania major	hypothetical protein, conserved	0.0047	0.0093	0.0346
Giardia lamblia	Histone deacetylase	0.028	0.0789	0.078
Trichomonas vaginalis	histone deacetylase, putative	0.028	0.0789	0.078
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0053	0.006
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0093	0.0324
Echinococcus multilocularis	histone deacetylase 8	0.0138	0.0365	0.0408
Plasmodium vivax	potassium channel, putative	0.0047	0.0093	0.0899
Leishmania major	histone deacetylase, putative	0.028	0.0789	0.3249
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.028	0.0789	0.078
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0365	0.1043	0.3656
Schistosoma mansoni	calcium-activated potassium channel	0.0923	0.2713	0.3031
Schistosoma mansoni	histone deacetylase 1 2 3	0.0138	0.0365	0.0408
Trichomonas vaginalis	histone deacetylase, putative	0.028	0.0789	0.078

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 17.5 uM	Compound was tested for the inhibition of human leukocyte elastase (HLE)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL542119

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1038986