Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0601 | 0.427 | 0.6399 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0838 | 0.6674 | 0.6674 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Toxoplasma gondii | cathepsin B | 0.0485 | 0.3093 | 0.4634 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0886 | 0.0886 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0267 | 0.0886 | 0.0886 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Plasmodium vivax | vivapain-1 | 0.0447 | 0.2706 | 0.4054 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0447 | 0.2706 | 0.2706 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.2706 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0838 | 0.6674 | 0.6674 |
Brugia malayi | cathepsin L-like precursor | 0.0571 | 0.3968 | 0.3968 |
Echinococcus multilocularis | cathepsin L | 0.0447 | 0.2706 | 0.2706 |
Echinococcus granulosus | cathepsin b | 0.1166 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1166 | 1 | 1 |
Plasmodium vivax | vivapain-3 | 0.0447 | 0.2706 | 0.4054 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0571 | 0.3968 | 0.3968 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0886 | 0.0886 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0485 | 0.3093 | 0.0976 |
Echinococcus granulosus | cathepsin l1 | 0.0838 | 0.6674 | 0.6674 |
Entamoeba histolytica | cysteine protease, putative | 0.0838 | 0.6674 | 1 |
Echinococcus granulosus | cathepsin L | 0.0447 | 0.2706 | 0.2706 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0447 | 0.2706 | 0.2706 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0702 | 0.5298 | 0.5298 |
Toxoplasma gondii | cathepsin CPL | 0.0838 | 0.6674 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0838 | 0.6674 | 0.6674 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0267 | 0.0886 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.3968 | 0.3968 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0495 | 0.0495 |
Echinococcus granulosus | cathepsin b | 0.1166 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0447 | 0.2706 | 0.2706 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1166 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0838 | 0.6674 | 0.6674 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0838 | 0.6674 | 0.6674 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0838 | 0.6674 | 1 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0643 | 0.4699 | 0.4699 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0571 | 0.3968 | 0.3968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0447 | 0.2706 | 0.4054 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0186 | 0.0069 | 0.0069 |
Giardia lamblia | Cathepsin B precursor | 0.0485 | 0.3093 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0571 | 0.3968 | 0.5946 |
Plasmodium vivax | unspecified product | 0.0267 | 0.0886 | 0.1328 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0186 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | fibroinase | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0571 | 0.3968 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.0495 | 0.0495 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0069 | 0.0069 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0485 | 0.3093 | 0.3093 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Brugia malayi | hypothetical protein | 0.0228 | 0.0495 | 0.0495 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0267 | 0.0886 | 0.0886 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0838 | 0.6674 | 0.6674 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0571 | 0.3968 | 0.3968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0571 | 0.3968 | 0.3968 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.3968 | 0.3968 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Echinococcus granulosus | cysteine protease | 0.0447 | 0.2706 | 0.2706 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0702 | 0.5298 | 0.5298 |
Onchocerca volvulus | Cathepsin F homolog | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1166 | 1 | 1 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0643 | 0.4699 | 0.4699 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0601 | 0.427 | 0.6399 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0886 | 0.0886 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0186 | 0.0069 | 0.0069 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0485 | 0.3093 | 0.4634 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Echinococcus multilocularis | cathepsin b | 0.1166 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0447 | 0.2706 | 0.2706 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.0495 | 0.0495 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0267 | 0.0886 | 0.0886 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1166 | 1 | 1 |
Onchocerca volvulus | 0.0571 | 0.3968 | 0.5946 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0447 | 0.2706 | 0.2706 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0447 | 0.2706 | 0.2706 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0485 | 0.3093 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1166 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Plasmodium vivax | unspecified product | 0.0447 | 0.2706 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1166 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0447 | 0.2706 | 0.4054 |
Leishmania major | cysteine peptidase A (CPA) | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0838 | 0.6674 | 0.6674 |
Onchocerca volvulus | Cathepsin L homolog | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0571 | 0.3968 | 0.5946 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.3838 | 0.3838 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0838 | 0.6674 | 0.6674 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Brugia malayi | Cathepsin L-like precursor | 0.0571 | 0.3968 | 0.3968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.2706 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0485 | 0.3093 | 0.3093 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0838 | 0.6674 | 0.6674 |
Plasmodium vivax | vivapain-2 | 0.0838 | 0.6674 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0447 | 0.2706 | 0.2706 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0447 | 0.2706 | 0.2706 |
Echinococcus granulosus | tumor protein p63 | 0.0366 | 0.189 | 0.189 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0643 | 0.4699 | 0.4699 |
Onchocerca volvulus | Cathepsin L homolog | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0267 | 0.0886 | 0.0886 |
Loa Loa (eye worm) | cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Loa Loa (eye worm) | cathepsin B | 0.0485 | 0.3093 | 0.3093 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0643 | 0.4699 | 0.4699 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0447 | 0.2706 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0485 | 0.3093 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0571 | 0.3968 | 0.3968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Echinococcus multilocularis | tumor protein p63 | 0.0366 | 0.189 | 0.189 |
Trypanosoma cruzi | cysteine protease, putative | 0.0447 | 0.2706 | 0.2706 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.3968 | 0.3968 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0838 | 0.6674 | 0.6674 |
Schistosoma mansoni | cathepsin s | 0.0267 | 0.0886 | 0.0886 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0267 | 0.0886 | 0.0886 |
Echinococcus granulosus | voltage gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Plasmodium vivax | vivapain-2 | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 29 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.