Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | choline o-acyltransferase | 0.0208 | 0.0679 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0208 | 0.0679 | 0.0356 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0298 | 0.1221 | 0.1715 |
Brugia malayi | Choline O-acetyltransferase | 0.0208 | 0.0679 | 0.0356 |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.0417 | 0.0159 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0298 | 0.1221 | 0.1123 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.0417 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0679 | 0.0356 |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.0417 | 0.0085 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0298 | 0.1221 | 0.0917 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0208 | 0.0679 | 0.0356 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0298 | 0.1221 | 0.1123 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0208 | 0.0679 | 0.0356 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1011 | 0.5504 | 1 |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0208 | 0.0679 | 0.0666 |
Brugia malayi | Choline O-acetyltransferase | 0.0208 | 0.0679 | 0.0356 |
Schistosoma mansoni | choline o-acyltransferase | 0.0208 | 0.0679 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1011 | 0.5504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1759 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.0417 | 0.0159 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1011 | 0.5504 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1011 | 0.5504 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1011 | 0.5504 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0298 | 0.1221 | 0.0917 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.0417 | 0.0085 |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.0208 | 0.0679 | 0.0666 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0298 | 0.1221 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0298 | 0.1221 | 0.1715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -4 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.