Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Cavia porcellus | Histamine H1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0033 | 0.1919 | 0.1865 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1919 | 0.1923 |
Loa Loa (eye worm) | brahma associated protein | 0.0025 | 0.1095 | 0.1097 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0256 | 0.0256 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0106 | 0.9976 | 0.9976 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0025 | 0.1095 | 0.1036 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0063 | 0.5251 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1919 | 0.1865 |
Onchocerca volvulus | 0.0033 | 0.1919 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1919 | 0.1953 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0106 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0025 | 0.1095 | 0.1036 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1919 | 0.1865 |
Brugia malayi | hypothetical protein | 0.0095 | 0.8771 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0025 | 0.1095 | 0.1036 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0106 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1853 | 0.1858 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1919 | 0.1865 |
Schistosoma mansoni | lamin | 0.0033 | 0.1919 | 0.0928 |
Onchocerca volvulus | 0.0033 | 0.1919 | 1 | |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0106 | 1 | 1 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0063 | 0.5251 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1919 | 0.1923 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1919 | 0.1953 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1919 | 0.1865 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0106 | 0.9976 | 1 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0106 | 1 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0063 | 0.5251 | 0.5 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0106 | 1 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0106 | 0.9976 | 0.9976 |
Schistosoma mansoni | lamin | 0.0033 | 0.1919 | 0.0928 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1919 | 0.1865 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0106 | 0.9976 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0025 | 0.1095 | 0.1036 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.1095 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0063 | 0.5251 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1919 | 0.0928 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0106 | 1 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0025 | 0.1095 | 0.1097 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0106 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0025 | 0.1095 | 0.1036 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0025 | 0.1095 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1919 | 0.1923 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0063 | 0.5251 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0025 | 0.1095 | 0.0985 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0106 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0066 | 0.0066 |
Brugia malayi | brahma associated protein 60 kDa | 0.0025 | 0.1095 | 0.0985 |
Brugia malayi | brahma associated protein 60 kDa | 0.0025 | 0.1095 | 0.0985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.021 mg kg-1 | The compound was tested in vivo for inhibitory effect on 48-h homologous passive cutaneous anaphylaxis(PCA) in rats administered peroally | ChEMBL. | 1350797 |
ID50 (functional) | = 0.0041 mg kg-1 | The compound was tested in vivo for the inhibition of IgG1-mediated bronchoconstriction in guinea pig at 0.03 mg/kg administered peroally | ChEMBL. | 1350797 |
Inhibition (binding) | = -1 % | Binding affinity for Muscarinic acetylcholine receptor M1 from rat striatum, using [3H]-quinuclidinyl benzilate as radioligand at 10 uM. | ChEMBL. | 1350797 |
Inhibition (binding) | = -1 % | Binding affinity for Muscarinic acetylcholine receptor M1 from rat striatum, using [3H]-quinuclidinyl benzilate as radioligand at 10 uM. | ChEMBL. | 1350797 |
Ki (binding) | = 5.2 nM | Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]-pyrilamine as radioligand at 0.1 microM. | ChEMBL. | 1350797 |
Ki (binding) | = 5.2 nM | Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]-pyrilamine as radioligand at 0.1 microM. | ChEMBL. | 1350797 |
Potency (functional) | = 0.0056 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.