Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0364 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0511 | 0.0511 |
Plasmodium vivax | SET domain protein, putative | 0.0058 | 0.0646 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1718 | 0.3018 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0214 | 0.0214 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0511 | 0.0898 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2629 | 0.261 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.051 | 0.0896 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0025 | 0.0006 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0177 | 0.2373 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0025 | 0.0025 |
Treponema pallidum | polypeptide deformylase (def) | 0.0463 | 0.6542 | 0.5 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0214 | 0.0214 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2629 | 0.261 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0025 | 0.0006 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.185 | 0.185 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0463 | 0.6542 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0056 | 0.0615 | 0.0615 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0214 | 0.0189 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0214 | 0.0375 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0353 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0177 | 0.2373 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0058 | 0.0646 | 0.0646 |
Plasmodium falciparum | peptide deformylase | 0.0463 | 0.6542 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0177 | 0.2373 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.0214 | 0.0189 |
Brugia malayi | hypothetical protein | 0.0132 | 0.1718 | 0.2991 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0058 | 0.0646 | 0.0622 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0285 | 0.0502 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0511 | 0.0487 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0364 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.1793 | 0.1793 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0214 | 0.0214 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0025 | 0.0025 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.0404 | 0.0404 |
Onchocerca volvulus | 0.0058 | 0.0646 | 0.0687 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.0646 | 0.0622 |
Plasmodium vivax | peptide deformylase, putative | 0.0463 | 0.6542 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1718 | 0.2391 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0214 | 0.0375 |
Echinococcus granulosus | geminin | 0.0194 | 0.2629 | 0.2629 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.185 | 0.3225 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0511 | 0.0511 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0025 | 0.0044 |
Mycobacterium ulcerans | peptide deformylase | 0.0463 | 0.6542 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0405 | 0.5692 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0364 | 1 |
Chlamydia trachomatis | peptide deformylase | 0.0463 | 0.6542 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0511 | 0.0511 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0701 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0511 | 0.0863 |
Toxoplasma gondii | hypothetical protein | 0.0463 | 0.6542 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1718 | 0.2391 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0511 | 0.0487 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0214 | 0.0338 |
Schistosoma mansoni | lamin | 0.0028 | 0.0214 | 0.0189 |
Trichomonas vaginalis | set domain proteins, putative | 0.0461 | 0.6506 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0405 | 0.5692 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0025 | 0.0025 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0177 | 0.2373 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0022 | 0.0039 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0214 | 0.0214 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1718 | 0.3018 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0025 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0285 | 0.0261 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0511 | 0.0511 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0646 | 0.1135 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0285 | 0.0465 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.185 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0214 | 0.0375 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0058 | 0.0646 | 0.0646 |
Echinococcus granulosus | lamin | 0.0028 | 0.0214 | 0.0214 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.051 | 0.0896 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.0646 | 0.0622 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0177 | 0.2373 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0214 | 0.0338 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.185 | 0.3251 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0177 | 0.2373 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.051 | 0.086 |
Brugia malayi | Pre-SET motif family protein | 0.0058 | 0.0646 | 0.11 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0701 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0463 | 0.6542 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.0646 | 0.0622 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0364 | 0.0364 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0177 | 0.2373 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0058 | 0.0646 | 0.0646 |
Echinococcus multilocularis | geminin | 0.0194 | 0.2629 | 0.2629 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0364 | 0.0339 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0364 | 0.0339 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.051 | 0.086 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0511 | 0.0487 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0058 | 0.0646 | 0.0395 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0025 | 0.0025 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0364 | 0.0603 |
Onchocerca volvulus | 0.0461 | 0.6506 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0206 | 0.0362 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0463 | 0.6542 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.