Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0351 | 0.0823 | 0.0725 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0351 | 0.0823 | 0.0725 |
Toxoplasma gondii | hypothetical protein | 0.0351 | 0.0823 | 1 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0351 | 0.0823 | 0.0725 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.0823 | 0.0802 |
Trypanosoma cruzi | GUP1, putative | 0.0351 | 0.0823 | 1 |
Loa Loa (eye worm) | MBOAT family protein | 0.0351 | 0.0823 | 0.0802 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0351 | 0.0823 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0106 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0351 | 0.0823 | 1 |
Echinococcus multilocularis | Membrane bound O acyl transferase, MBOAT | 0.0351 | 0.0823 | 0.0725 |
Brugia malayi | MBOAT family protein | 0.0351 | 0.0823 | 0.0823 |
Echinococcus granulosus | lysophospholipid acyltransferase 7 | 0.0351 | 0.0823 | 0.0725 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0351 | 0.0823 | 0.0725 |
Onchocerca volvulus | 0.0351 | 0.0823 | 0.5 | |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0351 | 0.0823 | 0.0725 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0351 | 0.0823 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0106 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0351 | 0.0823 | 0.0725 |
Leishmania major | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.0823 | 0.0802 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.0823 | 0.0802 |
Trypanosoma cruzi | GUP1, putative | 0.0351 | 0.0823 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0351 | 0.0823 | 0.5 |
Echinococcus granulosus | membrane bound acyltransferase:hhat | 0.0351 | 0.0823 | 0.0725 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0351 | 0.0823 | 0.0725 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0351 | 0.0823 | 0.5 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0351 | 0.0823 | 0.0725 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0023 | 0.0023 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0106 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Brugia malayi | MBOAT family protein | 0.0351 | 0.0823 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.0823 | 0.0802 |
Leishmania major | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0351 | 0.0823 | 0.0725 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0351 | 0.0823 | 0.5 |
Loa Loa (eye worm) | hhat protein | 0.0351 | 0.0823 | 0.0802 |
Loa Loa (eye worm) | hhat protein | 0.0351 | 0.0823 | 0.0802 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0351 | 0.0823 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0351 | 0.0823 | 0.5 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.0351 | 0.0823 | 0.0725 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.407 | 1 | 1 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.407 | 1 | 1 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0351 | 0.0823 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.3719 | 0.9135 | 0.9125 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0351 | 0.0823 | 0.0725 |
Brugia malayi | Hhat protein | 0.0351 | 0.0823 | 0.0823 |
Loa Loa (eye worm) | MBOAT family protein | 0.0351 | 0.0823 | 0.0802 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0351 | 0.0823 | 1 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0351 | 0.0823 | 0.0725 |
Trichomonas vaginalis | porcupine, putative | 0.0351 | 0.0823 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0351 | 0.0823 | 0.5 |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.0351 | 0.0823 | 0.0725 |
Echinococcus granulosus | Membrane bound O acyl transferase MBOAT | 0.0351 | 0.0823 | 0.0725 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0351 | 0.0823 | 0.0725 |
Leishmania major | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0351 | 0.0823 | 1 |
Loa Loa (eye worm) | MBOAT family protein | 0.407 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0106 | 0.1033 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0351 | 0.0823 | 0.0802 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0854 | 0.2065 | 0.198 |
Schistosoma mansoni | zinc finger protein | 0.407 | 1 | 1 |
Echinococcus multilocularis | membrane bound acyltransferase:hhat | 0.0351 | 0.0823 | 0.0725 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0106 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0351 | 0.0823 | 1 |
Echinococcus multilocularis | lysophospholipid acyltransferase 7 | 0.0351 | 0.0823 | 0.0725 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0351 | 0.0823 | 0.0802 |
Echinococcus multilocularis | zinc finger protein | 0.3719 | 0.9135 | 0.9125 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0351 | 0.0823 | 1 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0351 | 0.0823 | 0.0725 |
Brugia malayi | MBOAT family protein | 0.0351 | 0.0823 | 0.0823 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0351 | 0.0823 | 0.0725 |
Brugia malayi | MBOAT family protein | 0.0351 | 0.0823 | 0.0823 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0351 | 0.0823 | 0.5 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0351 | 0.0823 | 0.0725 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0106 | 0.1033 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0351 | 0.0823 | 0.0725 |
Brugia malayi | diacylglycerol acyltransferase | 0.0351 | 0.0823 | 0.0823 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0351 | 0.0823 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0351 | 0.0823 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 5 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.